Diagnosis and complications of Cushing's disease: gender-related differences.

abstract：OBJECTIVE:To systematically evaluate low serum adiponectin level as a risk factor for cardiovascular disease (CVD). A meta-analysis was performed to quantitatively analyse the association of serum total adiponectin level with CVD using previous case-control studies in Han Chinese populations. METHODS:Several electroni...

journal_title：Clinical endocrinology

authors： Zhang BC,Liu WJ,Che WL,Xu YW

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:Macroprolactinomas are pituitary tumours that can be managed with dopamine agonists (DA), surgery and radiotherapy. We aimed to assess the outcomes of these treatment modalities. DESIGN:Retrospective case-note study of patients managed in a single tertiary referral centre. PATIENTS:One hundred patients (68...

journal_title：Clinical endocrinology

authors： Green AI,Sherlock M,Stewart PM,Gittoes NJ,Toogood AA

更新日期：2014-07-01 00:00:00

abstract：:The citric acid cycle, also known as the Krebs cycle, plays an integral role in cellular metabolism and aerobic respiration. Mutations in genes encoding the citric acid cycle enzymes succinate dehydrogenase, fumarate hydratase and malate dehydrogenase all predispose to hereditary tumour syndromes. The succinate dehydr...

journal_title：Clinical endocrinology

authors： MacFarlane J,Seong KC,Bisambar C,Madhu B,Allinson K,Marker A,Warren A,Park SM,Giger O,Challis BG,Maher ER,Casey RT

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Nonclassical congenital adrenal hyperplasia (NC-CAH) is caused by mutations of the CYP21A2 gene. The clinical manifestations and hormonal derangements of NC-CAH are quite variable. OBJECTIVES:(i) To define the phenotype and its relation to genotype according to gender and age and (ii) to evaluate the validi...

journal_title：Clinical endocrinology

authors： Livadas S,Dracopoulou M,Dastamani A,Sertedaki A,Maniati-Christidi M,Magiakou AM,Kanaka-Gantenbein C,Chrousos GP,Dacou-Voutetakis C

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:Although insulin has been shown to stimulate ovarian steroidogenesis and hyperinsulinaemia has been implicated in the raised androgen levels found in diseases associated with significant insulin resistance, ovarian function has not been studied so far in women with NIDDM. We have assessed ovarian function in ...

journal_title：Clinical endocrinology

authors： Stamataki KE,Spina J,Rangou DB,Chlouverakis CS,Piaditis GP

更新日期：1996-11-01 00:00:00

abstract：:In 44 patients with acromegaly treated by transsphenoidal pituitary microsurgery, the relationship between changes in pre- and post-operative GH dynamics and postoperative fasting plasma GH levels was examined to clarify which is the optimal approach for evaluating postoperative removal of the tumour. TRH, LHRH and br...

journal_title：Clinical endocrinology

authors： Karashima T,Kato K,Nawata H,Ikuyama S,Ibayashi H,Nakagaki H,Kitamura K

更新日期：1986-08-01 00:00:00

abstract：OBJECTIVE:Androgen insensitivity syndromes (AIS) in subjects with 46, XY karyotype and normal or even elevated androgen blood levels are characterized by various aberrations in male differentiation and virilization. AIS is often accompanied by a broad spectrum of abnormal binding characteristics of the androgen recepto...

journal_title：Clinical endocrinology

authors： Weidemann W,Linck B,Haupt H,Mentrup B,Romalo G,Stockklauser K,Brinkmann AO,Schweikert HU,Spindler KD

更新日期：1996-12-01 00:00:00

abstract：:The ratios of reverse triiodothyronine (rT3) to triiodothyronine (T3) concentrations were similar (0.89 +/- 0.09) in twenty-three autonomous thyroid nodules (fourteen decompensated, nine compensated) and paranodular tissues (0.82 +/- 0.08), whereas the serum ratio was significantly lower (0.098 +/- 0.014). This is com...

journal_title：Clinical endocrinology

authors： Reinwein D,Durrer H,Emrich D,Meinhold H,Wenzel KW

更新日期：1977-08-01 00:00:00

abstract：OBJECTIVES:An inverse relationship has been shown between body mass index (BMI) and the peak growth hormone (GH) response to stimulation in adults and in children with short stature. This relation is observed even within a normal range of BMI. The aim of this study was to investigate the effect of BMI on the GH respons...

journal_title：Clinical endocrinology

authors： Loche S,Guzzetti C,Pilia S,Ibba A,Civolani P,Porcu M,Minerba L,Casini MR

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:Disordered water balance causes substantial morbidity in a subset of schizophrenics and is the consequence of unexplained defects in the regulation of fluid intake and antidiuretic function. We aimed to determine whether oropharyngeal regulation of water balance is altered in these patients. DESIGN:A 2-hour ...

journal_title：Clinical endocrinology

authors： Goldman MB,Robertson GL,Hedeker D

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVES:Papillary thyroid microcarcinoma (PTMC) has an excellent prognosis with an indolent disease course. However, some PTMCs have an aggressive course with lateral cervical lymph node (LCLN) metastasis or distant metastasis. This study aimed to evaluate the pre-operative features of PTMC associated with LCLN meta...

journal_title：Clinical endocrinology

authors： Jeon MJ,Chung MS,Kwon H,Kim M,Park S,Baek JH,Song DE,Sung TY,Hong SJ,Kim TY,Kim WB,Shong YK,Lee JH,Kim WG

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the diagnostic performance of pre-operative staging ultrasound (US) according to body mass index (BMI) in patients with papillary thyroid carcinoma (PTC) PATIENTS AND METHODS: This retrospective study included 625 patients with PTC who underwent pre-operative staging U...

journal_title：Clinical endocrinology

authors： Choi JS,Lee HS,Kim EK,Moon HJ,Kwak JY

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:TSH suppression therapy has been reported to be effective in some cases of papillary carcinoma of the thyroid. However, there has been little information regarding the status of expression of TSH-R mRNA in papillary carcinomas. Therefore, we examined the expression of TSH receptor (TSH-R) mRNA in thyroid tumo...

journal_title：Clinical endocrinology

authors： Tanaka K,Inoue H,Miki H,Komaki K,Monden Y

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVE:To document current practices in the approach to low testosterone in older men. Given that recommendations are based on low-level evidence, we hypothesized that there would be a wide variability in clinical practice patterns. DESIGN:Members of all major endocrine and andrological societies were invited to pa...

journal_title：Clinical endocrinology

authors： Grossmann M,Anawalt BD,Wu FC

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:Identification of the novel endocrine role of osteocalcin (OC) and its receptor GPRC6A has given rise to a new branch of research in OC/GPRC6A axis related to glucose metabolism. GPRC6A- and OC-deficient mice share features of the metabolic syndrome, in addition to male infertility. Recently, the polymorphism...

journal_title：Clinical endocrinology

authors： Di Nisio A,Rocca MS,Fadini GP,De Toni L,Marcuzzo G,Marescotti MC,Sanna M,Plebani M,Vettor R,Avogaro A,Foresta C

更新日期：2017-02-01 00:00:00

abstract：:Serum thyroxine was consistently unmeasurable by radioimmunoassay in an elderly patient with myxoedema after successful treatment with oral thyroxine. Abnormal binding of thyroxine was suspected and shown to be due to the presence in serum of antibodies of the IgG variety. The characteristics of these antibodies with ...

journal_title：Clinical endocrinology

authors： Pearce CJ,Byfield PG,Edmonds CJ,Lalloz MR,Himsworth RL

更新日期：1981-07-01 00:00:00

abstract：OBJECTIVE:Adrenal crises are potentially life-threatening complications in patients with adrenal insufficiency (AI). Our objective was to investigate the frequency of adrenal crises in different forms of AI. DESIGN/PATIENTS:The Statutory Health Insurance (SHI) database of the Techniker Krankenkasse - covering more tha...

journal_title：Clinical endocrinology

authors： Meyer G,Badenhoop K,Linder R

更新日期：2016-09-01 00:00:00

abstract：:A 39-year-old woman presented with secondary amenorrhoea in the absence of galactorrhoea, hirsutism or virilization. Investigation revealed a strikingly elevated serum testosterone, dihydrotesterone, free testosterone and LH level. At laparotomy a large granulosa cell tumour was encountered and totally removed. Analys...

journal_title：Clinical endocrinology

authors： Taylor HC,Velasco ME,Flores SG,Berg G,Brown TR

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:Iodide (I(-)) is crucial for foetal thyroid function. Foetal iodide results from maternal circulating iodide and from deiodination of iodothyronines within the placenta. The Na(+)/I(-) symporter (NIS) localized in placental cells appears to be involved in iodide exchange. Low NIS expression has been reported...

journal_title：Clinical endocrinology

authors： Di Cosmo C,Fanelli G,Tonacchera M,Ferrarini E,Dimida A,Agretti P,De Marco G,Vitti P,Pinchera A,Bevilacqua G,Naccarato AG,Viacava P

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:In the 8th edition American Joint Committee on Cancer (AJCC) tumour-node-metastasis (TNM) staging system (TNM-8), changes have been made regarding anaplastic thyroid carcinoma (ATC) compared with the 7th edition (TNM-7). The major changes are that anaplastic ATC now has the same T stage definitions as differe...

journal_title：Clinical endocrinology

authors： Xiang J,Wang Z,Sun W,Zhang H

更新日期：2020-12-26 00:00:00

abstract：:An oestrogen provocation test was performed in five healthy women during chronic intranasal treatment with 400 or 600 micrograms of the superactive LHRH agonist D-Ser(TBU)6-EA10-LHRH daily. Oestradiol benzoate 2.5 mg was administered intramuscularly after at least 3 months of LHRH agonist treatment. The serum levels o...

journal_title：Clinical endocrinology

authors： Bergquist C,Nillius SJ,Wide L

更新日期：1982-02-01 00:00:00

abstract：:A controlled therapeutic trial on seventy-four 70-year-old women was carried out with the purpose of finding the optimal treatment for post menopausal osteoporosis. The bone mineral content (BMC) was measured by I-photonabsorptiometry at two sites in the distal part of the forearms, where the trabecular/cortical ratio...

journal_title：Clinical endocrinology

authors： Jensen GF,Christiansen C,Transbøl I

更新日期：1982-05-01 00:00:00

abstract：OBJECTIVE:The standard ACTH test in clinical use employs a pharmacological dose of ACTH which assesses the maximum secretory capacity of the adrenal cortex. We have investigated the responses of plasma adrenocortical steroids including cortisol, aldosterone and dehydroepiandrosterone (DHEA) to physiological doses of AC...

journal_title：Clinical endocrinology

authors： Daidoh H,Morita H,Mune T,Murayama M,Hanafusa J,Ni H,Shibata H,Yasuda K

更新日期：1995-09-01 00:00:00

abstract：RATIONALE:In vitro fertilization (IVF) is a common treatment for infertility. In mice, IVF is associated with development of glucose intolerance. However, human data are limited regarding the metabolic, endocrine and inflammatory effects of IVF therapy in IVF-conceived pregnancies. OBJECTIVE:To explore effects of IVF ...

journal_title：Clinical endocrinology

authors： Coussa A,Hasan HA,Barber TM

更新日期：2020-12-01 00:00:00

abstract：:An immunochemiluminometric assay has been developed for the measurement of free T4 concentrations in serum. The assay uses chemiluminescent acridinium ester labelled monoclonal antibodies which react with free T4 in the sample. A T4-rabbit immunoglobulin G conjugate competes for antibody binding sites, immune-complexe...

journal_title：Clinical endocrinology

authors： Sturgess ML,Weeks I,Evans PJ,Mpoko CN,Laing I,Woodhead JS

更新日期：1987-09-01 00:00:00

abstract：OBJECTIVE:To audit the efficacy of quinagolide (CV205-502, Norprolac, Sandoz) in lowering prolactin, and its tolerability, in patients with bromocriptine resistance (BCR) or bromocriptine intolerance (BCI), in view of the paucity of results published in patients specifically with BCR or BCI, by collating results in our...

journal_title：Clinical endocrinology

authors： Vilar L,Burke CW

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:Heterozygous inactivating mutations of the calcium-sensing receptor (CaR) gene cause familial hypocalciuric hypercalcaemia (FHH), a generally benign disorder characterized by mild to moderate PTH-dependent hypercalcaemia. We aimed to identify the causative CaR mutations in three families with FHH and examine ...

journal_title：Clinical endocrinology

authors： Ward BK,Magno AL,Blitvich BJ,Rea AJ,Stuckey BG,Walsh JP,Ratajczak T

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVES:Alterations in protein expression of histone deacetylase 2 (HDAC2) have been demonstrated in various neoplasms, and lack of nuclear expression of HDAC2 has previously been shown in some human and canine corticotroph adenomas. This study aimed to examine HDAC2 expression in a Norwegian cohort of corticotroph ...

journal_title：Clinical endocrinology

authors： Evang JA,Borota OC,Melum E,Holm R,Ramm-Pettersen J,Bollerslev J,Berg JP

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:We compared the effectiveness of high intensity focused ultrasound (HIFU) and radioiodine (RAI) to treat patients carrying toxic thyroid nodule (TTN). Normalization of serum thyrotropin (TSH) 1 year after treatment was the primary end-point; concurrent changes in nodules' volume and scintigraphic pattern were a...

journal_title：Clinical endocrinology

authors： Giovanella L,Piccardo A,Pezzoli C,Bini F,Ricci R,Ruberto T,Trimboli P

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Osteocalcin is a bone-specific protein secreted by osteoblasts and often used as a bone formation biomarker. Rodent studies have reported a hormonal role of osteocalcin on glucose metabolism, increasing insulin secretion and sensitivity and increasing energy expenditure. However, it is unknown whether osteoca...

journal_title：Clinical endocrinology

authors： Rochefort GY,Rocher E,Aveline PC,Garnero P,Bab I,Chappard C,Jaffré C,Benhamou CL

更新日期：2011-08-01 00:00:00