Abstract：
BACKGROUND:Vertebral fractures in patients with cystic fibrosis (CF) may contribute to an accelerated decline in lung function and can be a contraindication to lung transplantation. In this study, we examined longitudinal change in bone mineral density (BMD) and the prevalence of vertebral fractures in adult CF patients, without lung-transplant, attending a Canadian specialty clinic. METHODS:Retrospective chart review of all patients attending an Adult Cystic Fibrosis Clinic at Hamilton Health Sciences in Hamilton, Canada. Forty-nine of 56 adults met inclusion criteria. Chest radiographs were graded by consensus approach using Genant's semi-quantitative method to identify and grade fractured vertebrae. Dual x-ray absorptiometry (DXA) scans were also reviewed. RESULTS:The mean age of the cohort was 25.2 years (SD 9.4), 43% were male. The mean body mass index (BMI) was 19.8 (2.8) for males and 21.7 (5.1) for females. At baseline, the rate of at least one vertebral fracture was 16.3%; rising to 21.3% (prevalent and incident) after a 3-year follow-up. The mean BMD T-or Z-scores at baseline were -0.80 (SD 1.1) at the lumbar spine, -0.57 (SD 0.97) at the proximal femur, and -0.71 (SD 1.1) at the whole body. Over approximately 4-years, the mean percent change in BMD was -1.93% at the proximal femur and -0.73% at the lumbar spine. CONCLUSION:Approximately one in five CF patients demonstrated at least one or more vertebral fractures. Moderate declines in BMD were observed. Given the high rate of vertebral fractures noted in this cohort of adult CF patients, and the negative impact they have on compromised lung functioning, regular screening for vertebral fractures should be considered on routine chest radiographs.
journal_name
BMC Musculoskelet Disordjournal_title
BMC musculoskeletal disordersauthors
Papaioannou A,Kennedy CC,Freitag A,O'Neill J,Pui M,Ioannidis G,Webber C,Pathak A,Hansen S,Hennessey R,Adachi JDdoi
10.1186/1471-2474-9-125subject
Has Abstractpub_date
2008-09-19 00:00:00pages
125issn
1471-2474pii
1471-2474-9-125journal_volume
9pub_type
杂志文章abstract：BACKGROUND:Obesity and musculoskeletal pain are strongly related, but there is emerging evidence that body fat, not body weight, may be a better indicator of risk. There is, therefore, a need to determine if body fat is associated with musculoskeletal pain as it may improve management strategies. The aim of this system...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章,meta分析
doi：10.1186/s12891-018-2137-0
更新日期：2018-07-18 00:00:00
abstract：BACKGROUND:In this study, we evaluated the changes which occurred in the epiligament, an enveloping tissue of the ligament, during the ligament healing. We assessed the association of epiligament elements that could be involved in ligament healing. METHODS:Thirty-two 8-month old male Wistar rats were used in this stud...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-11-117
更新日期：2010-06-13 00:00:00
abstract：BACKGROUND:Polyetheretherketone (PEEK) rod system is a novel pedicle-based dynamic stabilization system. This study evaluated clinical and radiographic outcomes of non-fusion surgery by PEEK rod systems for treatment of degenerative lumbar diseases with a 2-year follow-up. METHODS:From February 2012 to October 2012, 3...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-016-0913-2
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:The use of corticosteroids (e.g., dexamethasone) as treatment for tendinopathy has recently been questioned as higher risks for ruptures have been observed clinically. In vitro studies have reported that dexamethasone exposed tendon cells, tenocytes, show reduced cell viability and collagen production. Littl...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-016-1328-9
更新日期：2016-11-10 00:00:00
abstract：BACKGROUND:Vertebral fractures, the most common type of osteoporotic fractures, are associated with increased risk of subsequent fracture, morbidity, and mortality. The aim of this study was to examine the contribution of important risk factors to the variability in vertebral fracture risk. METHODS:Vertebral fracture ...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-13-163
更新日期：2012-08-31 00:00:00
abstract：BACKGROUND:Chronic neck pain after whiplash associated disorders (WAD) may lead to reduced displacement and peak velocity of neck movements. Dynamic neck movements in people with chronic WAD are also reported to display altered movement patterns such as increased irregularity, which is suggested to signify impaired mot...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-14-314
更新日期：2013-11-04 00:00:00
abstract：BACKGROUND:Plantaris tendon, peronus brevis tendon and flexor hallucis longus tendon augmentation, commonly used in Achilles tendon rupture, often lead to weakening of injured foot and they require the immobilization after the surgery. It is essential to develop the technique, which gives no such limitation and allows ...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-016-1099-3
更新日期：2016-06-03 00:00:00
abstract：BACKGROUND:Overall performance, particularly in a very popular sports activity such as running, is typically influenced by the status of the musculoskeletal system and the level of training and conditioning of the biological structures. Any change in the musculoskeletal system's biomechanics, especially in the feet and...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12891-016-1016-9
更新日期：2016-04-14 00:00:00
abstract：BACKGROUND:The optimal method for the reduction and fixation of posterior malleolar fracture (PMF) remains inconclusive. Currently, both of the indirect and direct reduction techniques are widely used. We aimed to compare the reduction quality and clinical outcome of posterior malleolar fracture managed with the direct...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-017-1475-7
更新日期：2017-03-14 00:00:00
abstract：BACKGROUND:Osteoarthritis (OA) and rheumatoid arthritis (RA) are diseases which result in the degeneration of the joint surface articular cartilage. Matrix metalloproteinases (MMPs) are enzymes that aid in the natural remodelling of tissues throughout the body including cartilage. However, some MMPs have been implicate...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-13-126
更新日期：2012-07-23 00:00:00
abstract：BACKGROUND:Total Hip Replacement (THR) is an effective treatment for end-stage hip osteoarthritis. Since the introduction of total joint replacement, the effect on the Sexual Quality of Life (SQoL) following THR has been addressed in scant studies. The aim of our study was to systematically review the literature, to su...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章,评审
doi：10.1186/s12891-016-1048-1
更新日期：2016-05-04 00:00:00
abstract：BACKGROUND:The clinical effectiveness of complementary and alternative medicines (CAMs) is widely debated because of a lack of clinical trials. The internet may provide an effective and economical approach for undertaking randomised controlled trials (RCTs) of low-risk interventions. We investigated whether the interne...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章,随机对照试验
doi：10.1186/1471-2474-9-4
更新日期：2008-01-11 00:00:00
abstract：BACKGROUND:Macrophages expressing the pro-angiogenic transcription factor hypoxia-inducible factor (HIF)-1alpha have been demonstrated in rheumatoid arthritis (RA) in the synovial tissue. Aim of the present study was to investigate intracellular signal transduction regulation of pro-inflammatory HIF-1 alpha expression ...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-11-61
更新日期：2010-03-30 00:00:00
abstract：BACKGROUND:The mechanism of pain after meniscus injury remains unknown. After injury, some individuals suffered from acute pain, while others suffer from delayed pain. A precise nociceptor distribution pattern may provide the answer to this question. METHODS:Twenty-two intact menisci (paired medial and lateral menisci...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-019-2706-x
更新日期：2019-07-22 00:00:00
abstract：BACKGROUND:Cervicogenic dizziness is a disabling condition characterised by postural unsteadiness that is aggravated by cervical spine movements and associated with a painful and/or stiff neck. Two manual therapy treatments (Mulligan's Sustained Natural Apophyseal Glides (SNAGs) and Maitland's passive joint mobilisatio...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章,随机对照试验
doi：10.1186/1471-2474-13-201
更新日期：2012-10-18 00:00:00
abstract：BACKGROUND:Tarsal tunnel syndrome is an entrapment neuropathy that can be provoked by either intrinsic or extrinsic factors that compresses the posterior tibial nerve beneath the flexor retinaculum. Osteochondroma, the most common benign bone tumor, seldom occur in foot or ankle. This is a rare case of tarsal tunnel sy...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-020-03530-9
更新日期：2020-07-25 00:00:00
abstract：BACKGROUND:Low-dye (LD) taping is commonly used to reduce rearfoot pronation. No studies have previously investigated the effectiveness of LD taping using both plantar pressure distribution (F-Scan) and 3-D (CODA) analysis of rearfoot motion. METHODS:20 healthy subjects with a navicular drop test exceeding 10 mm parti...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-9-111
更新日期：2008-08-18 00:00:00
abstract：BACKGROUND:Conversion of a knee arthrodesis to a Total Knee Arthroplasty is an uncommon procedure. Revision Total Knee Arthroplasty in this setting presents the surgeon with a number of challenges including the management of the extensor mechanism and patella. CASE PRESENTATION:We describe a unique case of a 69 years ...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-14-317
更新日期：2013-11-06 00:00:00
abstract：BACKGROUND:Compression of the tissue beneath tourniquets used in limb surgery is associated with varying degrees of soft tissue damage. The interaction between fluids and applied pressure seems to play an important role in the appearance of skin lesions. The extent of the transfer of force between the tourniquet and th...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-015-0454-0
更新日期：2015-01-31 00:00:00
abstract：BACKGROUND:Extended scope physiotherapists (ESP) are increasingly supplementing orthopaedic surgeons (OS) in diagnosing patients with musculoskeletal disorders. Studies have reported satisfactory diagnostic and treatment agreement between ESPs and OSs, but methodological study quality is generally low, and only few stu...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-020-03831-z
更新日期：2021-01-04 00:00:00
abstract：BACKGROUND:There is emerging evidence for a beneficial effect of meat consumption on the musculoskeletal system. However, whether it affects the risk of knee and hip osteoarthritis is unknown. We performed a prospective cohort study to examine the relationship between meat consumption and risk of primary hip and knee r...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-12-17
更新日期：2011-01-16 00:00:00
abstract：BACKGROUND:Chronic diseases and multimorbidity are increasingly common among persons in working age. This study explores the impact of type, number and combinations of chronic diseases with focus on the role of MSKD on (1) adverse work status (i.e. work disability (WD), economic unemployment (UE) or receiving a living ...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-016-1365-4
更新日期：2017-01-10 00:00:00
abstract：BACKGROUND:Percutaneous vertebroplasy (PVP) might lead to significant radiation exposure to patients, operators, and operating room personnel. Therefore, radiaton exposure is a concern. The aim of this study was to present a remote control cement delivery device and study whether it can reduce dose exposue to operators...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-15-260
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Osteoporosis is a major health problem worldwide, and is included in the WHO list of the top 10 major diseases. However, it is often undiagnosed until the first fracture occurs, due to inadequate patient education and lack of insurance coverage for screening tests. Anamnestic risk factors like positive famil...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-12-187
更新日期：2011-08-17 00:00:00
abstract：BACKGROUND:Caffeine is an active alkaloid that can cause damage to bones in formation during prenatal life into adulthood. This compound can pass across the placenta and into the mother's milk, causing a reduction in bone formation, growth and mass. The objective of this study was to examine the osteogenic potential of...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-015-0467-8
更新日期：2015-02-04 00:00:00
abstract：BACKGROUND:Range of abduction often decreases during Legg-Calvé-Perthes Disease (LCPD) disease. However, a good range of abduction is required during the course of LCPD, especially when containment surgery should be performed. This study aimed to investigate how many patients registered in the Swedish Pediatric Orthope...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-020-03705-4
更新日期：2020-11-05 00:00:00
abstract：BACKGROUND:Osteoporosis is a skeletal disease leading to an increased risk of bone fracture. Using a mouse osteoporosis model induced by administration of a receptor activator of nuclear factor kappa-B ligand (RANKL), salubrinal was recently reported as a potential therapeutic agent. To evaluate the role of salubrinal ...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-14-197
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:This scoping review aimed to investigate the literature on the anatomy of the psoas valley, an anterior depression on the acetabular rim, and propose a unified definition of the anatomical structure, describe its dimensions, anatomical variations and clinical implications. METHODS:A systematic computer sear...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章,评审
doi：10.1186/s12891-020-03241-1
更新日期：2020-04-10 00:00:00
abstract：BACKGROUND:Most composite indices of disease activity and response criteria in RA have been validated and compared in clinical trials rather than routine care. We therefore wanted to compare the performance of the DAS28, SDAI and CDAI activity indices, their activity states, their response criteria, and also compare wi...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-10-41
更新日期：2009-04-23 00:00:00
abstract：BACKGROUND:Repetitive and stressful work tasks have been linked to the development of pain in the trapezius muscle, although the underlying mechanisms still remain unclear. In earlier studies, it has been hypothesized that chronic muscle pain conditions are associated with imbalance in the autonomic nervous system, pre...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-10-63
更新日期：2009-06-07 00:00:00
