当前位置： SCI文献检索 > BMC MUSCULOSKELETAL DISORDERS期刊下所有文献 > Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study.

Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study.

Abstract：

BACKGROUND:Vertebral fractures, the most common type of osteoporotic fractures, are associated with increased risk of subsequent fracture, morbidity, and mortality. The aim of this study was to examine the contribution of important risk factors to the variability in vertebral fracture risk. METHODS:Vertebral fracture was ascertained by VFA method (DXA, GE Lunar Prodigy) in 2887 men and women, aged between 38 and 87 years, in the population-based Tromsø Study 2007/2008. Bone mineral density (BMD; g/cm2) at the hip was measured by DXA. Lifestyle information was collected by questionnaires. Multivariable logistic regression model, with anthropometric and lifestyle factors included, was used to assess the association between each or combined risk factors and vertebral fracture risk. Population attributable risk was estimated for combined risk factors in the final multivariable model. RESULTS:In both sexes, age (odds ratio [OR] per 5 year increase: 1.32; 95% CI 1.19-1.45 in women and 1.21; 95% CI 1.10-1.33 in men) and BMD (OR per SD decrease: 1.60; 95% CI 1.34-1.90 in women and1.40; 95% CI 1.18-1.67 in men) were independent risk factors for vertebral fracture. At BMD levels higher than 0.85 g/cm2, men had a greater risk of fracture than women (OR 1.52; 95% CI 1.14-2.04), after adjusting for age. In women and men, respectively, approximately 46% and 33% of vertebral fracture risk was attributable to advancing age (more than 70 years) and low BMD (less than 0.85 g/cm2), with the latter having a greater effect than the former. CONCLUSIONS:These data confirm that age and BMD are major risk factors for vertebral fracture risk. However, in both sexes the two factors accounted for less than half of fracture risk. The identification of individuals with vertebral fracture is still a challenge.

journal_name

BMC Musculoskelet Disord

journal_title

BMC musculoskeletal disorders

authors

Waterloo S,Nguyen T,Ahmed LA,Center JR,Morseth B,Nguyen ND,Eisman JA,Søgaard AJ,Emaus N

doi

10.1186/1471-2474-13-163

subject

Has Abstract

pub_date

2012-08-31 00:00:00

pages

163

issn

1471-2474

pii

1471-2474-13-163

journal_volume

pub_type

杂志文章

在线工具

Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study.