Abstract:
BACKGROUND:Caffeine is an active alkaloid that can cause damage to bones in formation during prenatal life into adulthood. This compound can pass across the placenta and into the mother's milk, causing a reduction in bone formation, growth and mass. The objective of this study was to examine the osteogenic potential of osteoblasts extracted from neonatal rats born to mothers treated with caffeine throughout pregnancy. METHODS:Twenty-four adult Wistar rats were randomly divided into four groups, consisting of one control group and three groups that were treated with 25, 50, or 100 mg/kg of caffeine by an oral-gastric probe throughout the duration of the experimental period (pregnancy). At birth, three puppies from each dam in each group were euthanized, and osteoblasts were extracted from the calvaria of these pups for in vitro testing. RESULTS:The osteoblasts extracted from the pups of rats that received 50 mg/kg caffeine during pregnancy exhibited increased expression of osteocalcin, osteopontin, sialoprotein, runx-2, alkaline phosphatase and type I collagen transcripts, resulting in increased synthesis of mineralization nodules. CONCLUSIONS:Neonates from rats treated with 50 mg/kg caffeine during pregnancy contained osteoblasts with a higher osteogenic potential characterized by increased expression of osteocalcin, osteopontin, sialoprotein, runx-2, alkaline phosphatase and type I collagen and increased synthesis of mineralization nodules.
journal_name
BMC Musculoskelet Disordjournal_title
BMC musculoskeletal disordersauthors
Reis AM,Ribeiro LG,Ocarino Nde M,Goes AM,Serakides Rdoi
10.1186/s12891-015-0467-8subject
Has Abstractpub_date
2015-02-04 00:00:00pages
10issn
1471-2474pii
s12891-015-0467-8journal_volume
16pub_type
杂志文章abstract:BACKGROUND:To examine whether number of physical therapy (PT) visits or amount of use of an internet-based exercise training (IBET) program is associated with differential improvement in outcomes for participants with knee osteoarthritis (OA). METHODS:A secondary analysis was performed using data from participants in ...
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pub_type: 杂志文章,meta分析,评审
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更新日期:2017-04-19 00:00:00
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更新日期:2016-04-08 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12891-016-0987-x
更新日期:2016-03-23 00:00:00
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更新日期:2016-03-22 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1186/s12891-016-1010-2
更新日期:2016-04-11 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2474-11-264
更新日期:2010-11-16 00:00:00
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pub_type: 杂志文章
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更新日期:2008-08-18 00:00:00