Non-Robertsonian translocation t (2;11) is associated with infertility in an oligospermic man.

Abstract:

:Infertility is a major health problem which affects approximately 22% of married couples in reproductive age. Chromosomal defects are the most common genetic abnormalities in infertile men, with an incidence of cytogenetic abnormalities ranging from 2.1% to 15.5%. We describe here the clinical and cytogenetic studies carried out in a couple with repeated abortions. Cytogenetic analysis of the couple showed a de novo chromosomal translocation t (2;11)(p14;q21) in the male partner and a normal 46, XX karyotype in the female counterpart. Such an autosomal translocation may lead to the disruption of genes responsible for spermatogenesis or impaired synaptic complex pairing during meiosis resulting in reproductive failure.

journal_name

Andrologia

journal_title

Andrologia

authors

Ananthapur V,Avvari S,Veena K,Sujatha M,Jyothy A

doi

10.1111/and.12120

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

453-5

issue

4

eissn

0303-4569

issn

1439-0272

journal_volume

46

pub_type

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