Abstract:
:Infertility is a major health problem which affects approximately 22% of married couples in reproductive age. Chromosomal defects are the most common genetic abnormalities in infertile men, with an incidence of cytogenetic abnormalities ranging from 2.1% to 15.5%. We describe here the clinical and cytogenetic studies carried out in a couple with repeated abortions. Cytogenetic analysis of the couple showed a de novo chromosomal translocation t (2;11)(p14;q21) in the male partner and a normal 46, XX karyotype in the female counterpart. Such an autosomal translocation may lead to the disruption of genes responsible for spermatogenesis or impaired synaptic complex pairing during meiosis resulting in reproductive failure.
journal_name
Andrologiajournal_title
Andrologiaauthors
Ananthapur V,Avvari S,Veena K,Sujatha M,Jyothy Adoi
10.1111/and.12120subject
Has Abstractpub_date
2014-05-01 00:00:00pages
453-5issue
4eissn
0303-4569issn
1439-0272journal_volume
46pub_type
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