A method of experimental rheumatoid arthritis induction using collagen type II isolated from chicken sternal cartilage.

abstract：:UbiA prenyltransferase domain containing 1 (UBIAD1) is closely associated with cardiovascular diseases. However, at the cellular level, little is known about how UBIAD1 is expressed and functions in cardiomyocyte hypertrophy. The aim of the present study was to investigate the expression and role of UBIAD1 in angioten...

journal_title：Molecular medicine reports

authors： Yan B,Sun Y,Wang J

更新日期：2017-11-01 00:00:00

abstract：:Krüppel-like factors (KLFs) regulate a wide variety of cellular functions and modulate pathological processes. In the present study, a post‑translational mechanism of microRNAs (miRs) was investigated in H2O2-induced human cardiomyocyte (HCM) injury. In H2O2‑cultured HCM cells, reactive oxygen species and apoptotic ce...

journal_title：Molecular medicine reports

authors： Zhang X,Liu F,Wang Q,Geng Y

更新日期：2017-10-01 00:00:00

abstract：:Electroacupuncture (EA) has been documented as a form of therapy for chronic sinusitis (CRS). The present study aimed to assess the effects of EA combined with interleukin‑10 (IL‑10) overexpression on CRS in mice, and to investigate the associated mechanisms. A mouse model of CRS was established by the administration ...

journal_title：Molecular medicine reports

authors： Zhou L,Hong J,Wan Z,Lu X,Shao Y

更新日期：2019-08-01 00:00:00

abstract：:Magnesium, an important inorganic mineral component in bones, enhances osteoblast adhesion and osteogenic gene expression. Mg2+‑containing hydroxyapatite promotes mouse mesenchymal stem cell (MMSC) osteogenic differentiation. In the present study, MMSCs were cultured in media containing different concentrations of MgC...

journal_title：Molecular medicine reports

authors： Ni S,Xiong XB,Ni XY

更新日期：2020-11-01 00:00:00

abstract：:The development of acute lung injury (ALI) during sepsis almost doubles the mortality rate of patients. The efficacy of current treatment strategies is low as treatment is usually initiated following the onset of symptoms. Inflammation is one of the main mechanisms of autoimmune disorders and is a common feature of se...

journal_title：Molecular medicine reports

authors： Li T,Zhang J,Feng J,Li Q,Wu L,Ye Q,Sun J,Lin Y,Zhang M,Huang R,Cheng J,Cao Y,Xiang G,Zhang J,Wu Q

更新日期：2013-06-01 00:00:00

abstract：:Hair follicle stem cells (HFSCs) possess powerful expansion and multi‑differentiation potential, properties that place them at the forefront of the field of tissue engineering and stem cell‑based therapy. The aim of the present study was to investigate the differentiation of human HFSCs (hHFSCs) into cells of an endot...

journal_title：Molecular medicine reports

authors： Xu ZC,Zhang Q,Li H

更新日期：2014-01-01 00:00:00

abstract：:The production of reactive oxygen species (ROS) is a common phenomenon in podocyte impairment, which leads to the irreversible progression of chronic kidney diseases, such as diabetic kidney disease (DKD). Previous research has indicated that peroxisome proliferator‑activated receptor γ (PPARγ) coactivator‑1α (PGC‑1α)...

journal_title：Molecular medicine reports

authors： Zhang L,Liu J,Zhou F,Wang W,Chen N

更新日期：2018-03-01 00:00:00

abstract：:Osteopetrosis is a monogenic condition with various inheritance patterns, including autosomal dominant, autosomal recessive and X‑linked. Several disease‑causing genes have been identified and three distinguished types of osteopetrosis have been reported. In the present study, a family with osteopetrosis was investiga...

journal_title：Molecular medicine reports

authors： Yang Y,Ye W,Guo J,Zhao L,Tu M,Zheng Y,Li L

更新日期：2019-01-01 00:00:00

abstract：:The present study aimed to investigate the protective effect of mesenchymal stem cell (MSC) therapy in combination with p38 mitogen‑activated protein (MAPK) inhibition against myocardial infarction (MI) injury in rats, and to elucidate the underlying mechanisms. An MI model was established by ligation of the anterior ...

journal_title：Molecular medicine reports

authors： Zhang Z,Zhou S,Mei Z,Zhang M

更新日期：2017-09-01 00:00:00

abstract：:Nutrients are known to display pharmacologic activity against viruses and to exert cooperative effects in cells. To study the influence of nutrient cooperation on HIV production in chronically infected T lymphocytes, we evaluated the individual and combined effects of nutrients on HIV-1 reverse transcriptase (RT) rele...

journal_title：Molecular medicine reports

authors： Jariwalla RJ,Gangapurkar B,Pandit A,Kalinovsky T,Niedzwiecki A,Rath M

更新日期：2010-05-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL), the most frequently occurring type of lymphoid malignancy, has been demonstrated to be associated with mutations of Ten‑Eleven Translocation (TET). In order to explore the association between DLBCL and TET mutations, the present study analyzed the gene expression and methylation ...

journal_title：Molecular medicine reports

authors： Liu P,Jiang W,Zhao J,Zhang H

更新日期：2017-10-01 00:00:00

abstract：:Few studies have investigated the changes of Th1- and Th2-type cytokines in pulmonary embolism (PE) patients. In this study, the gene expression of interleukins and the balance of Th1- and Th2-type cytokines in the peripheral blood mononuclear cells (PBMCs) of PE patients and controls were investigated. A total of 20 ...

journal_title：Molecular medicine reports

authors： Duan Q,Lv W,Wang L,Gong Z,Wang Q,Song H,Wang H

更新日期：2013-01-01 00:00:00

abstract：:Parkinson's disease (PD) is one of the most common neurodegenerative diseases. For decades, the unilateral 6‑hydroxydopamine (6‑OHDA) rat model has been employed to investigate the pathogenesis and therapy of PD. However, the behavior and associated pathological features of the model long term have not previously been...

journal_title：Molecular medicine reports

authors： Su RJ,Zhen JL,Wang W,Zhang JL,Zheng Y,Wang XM

更新日期：2018-02-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by synovial inflammation. Fibroblast‑like synoviocytes (FLS) serve a vital role in the initiation and perpetuation of the immune response in patients with RA. The present study aimed to investigate the potential role of microRNA (miR)‑34a‑...

journal_title：Molecular medicine reports

authors： Hou C,Wang D,Zhang L

更新日期：2019-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common type of neurological disorder that results from brain cell death; however, not all brain regions are simultaneously affected to the same extent. Despite single biomarkers for AD having been determined on a genome‑wide scale, the differential co‑expression in gene pairs betwe...

journal_title：Molecular medicine reports

authors： Yu L,Qian S,Wei S

更新日期：2018-08-01 00:00:00

abstract：:Different sources of mesenchymal stem cells (MSCs) may differ in their biological characteristics, which are important for their clinical application. In the present study, MSCs were isolated from human exfoliated deciduous teeth (SHED), bone marrow, gingival tissue and umbilical cord tissue, and their biological char...

journal_title：Molecular medicine reports

authors： Li J,Xu SQ,Zhao YM,Yu S,Ge LH,Xu BH

更新日期：2018-12-01 00:00:00

abstract：:While most cancer types are resistant to mammalian target of rapamycin complex 1 (mTORC1) inhibitor rapamycin, recent studies have identified mTORC2 as an important prospective therapeutic target for cancer. The present study assessed the effects of mTORC2 inhibitor PP242 on the proliferation and migration of bladder ...

journal_title：Molecular medicine reports

authors： Zhang Z,Zhang G,Kong C,Gong D

更新日期：2016-01-01 00:00:00

abstract：:Previous studies have shown that (GM3), a ganglioside, suppresses hepatoma cell motility and migration by inhibiting phosphorylation of EGFR and the activity of the PI3K/AKT signaling pathway. Therefore, the aim of the present study was to investigate whether the combined treatment of CD82 with gangliosides can exert ...

journal_title：Molecular medicine reports

authors： Huang X,Li Y,He X,Chen Y,Wei W,Yang X,Ma K

更新日期：2020-11-01 00:00:00

abstract：:Neutrophilic airway inflammation in chronic lung infections caused by Pseudomonas aeruginosa (PA) is associated with T helper (Th)17 responses. Suppressor of cytokine signaling 3 (SOCS3) is the major negative modulator of Th17 function through the suppression of signal transducer and activator of transcription (STAT)3...

journal_title：Molecular medicine reports

authors： Ding FM,Liao RM,Chen YQ,Xie GG,Zhang PY,Shao P,Zhang M

更新日期：2017-07-01 00:00:00

abstract：:Asparaginase like 1 (ASRGL1) protein belongs to the N‑terminal nucleophile group, cleaving the isoaspartyl‑dipeptides and L‑asparagine by adding water. It tends to be overexpressed in cancerous tumors including ovarian cancer and breast tumors. The present study assessed the potential ability of ASRGL1 as a molecular ...

journal_title：Molecular medicine reports

authors： Lv XF,Hong HQ,Liu L,Cui SH,Ren CC,Li HY,Zhang XA,Zhang LD,Wei TX,Liu JJ,Xing WY,Fu H,Yan SJ

更新日期：2018-07-01 00:00:00

abstract：:Buckwheat flour is well known for its highly antioxidative ingredient, rutin. We have undertaken to examine alterations in the characteristics of rutin treated with various proteins. In this study, the radical scavenging activities of a rutin-ovalbumin complex were examined. Dissolved rutin hydrate and ovalbumin were ...

journal_title：Molecular medicine reports

authors： Awatsuhara R,Harada K,Maeda T,Nomura T,Nagao K

更新日期：2010-01-01 00:00:00

abstract：:Exploring the genetic basis for idiopathic congenital nystagmus is critical for improving our understanding of its molecular pathogenesis. In the present study, direct sequencing using gene specific primers was performed in order to identify the causative mutations in two brothers from a Chinese family who had been di...

journal_title：Molecular medicine reports

authors： Xiu Y,Yao Y,Yang T,Pan M,Yang H,Fang W,Gu F,Zhao J,Zhu Y

更新日期：2018-09-01 00:00:00

abstract：:Studies using animal models have demonstrated that probiotics may have a beneficial role in the prevention of colorectal cancer (CRC); however, the underlying mechanism of the beneficial effects of interventional probiotic treatment on gut microbiota has remained elusive. In the present study, pyrosequencing of the V3...

journal_title：Molecular medicine reports

authors： Gao Z,Guo B,Gao R,Zhu Q,Wu W,Qin H

更新日期：2015-10-01 00:00:00

abstract：:B7-H4 is a co‑inhibitory molecule of the B7 family, which is expressed on antigen‑presenting cells (APCs) and is able to limit the T‑cell immune response. Macrophages act as professional APCs and are important for immunoregulation of the tumor microenvironment in breast cancer. In order to identify the association bet...

journal_title：Molecular medicine reports

authors： Liu L,Li D,Chen S,Zhao R,Pang D,Li D,Fu Z

更新日期：2016-09-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is one of the highly malignant tumors and a serious threat to human health. The aim of the present study was to explore the underlying molecular mechanisms of SCLC. mRNA microarray datasets GSE6044 and GSE11969 were downloaded from Gene Expression Omnibus database, and the differentially ...

journal_title：Molecular medicine reports

authors： Wen P,Chidanguro T,Shi Z,Gu H,Wang N,Wang T,Li Y,Gao J

更新日期：2018-08-01 00:00:00

abstract：:The occurrence and development of hyperglycemia‑induced inflammation is associated with increased expression of receptor for advanced glycation end products (RAGE) and inflammatory factors, including IL‑1β, TNF‑α and IL‑6. Previous studies have reported that the nucleotide‑binding oligomerization domain‑like receptor ...

journal_title：Molecular medicine reports

authors： Jiang M,Wang X,Wang P,Peng W,Zhang B,Guo L

更新日期：2020-10-01 00:00:00

abstract：:Endothelial cell injury caused by reactive oxygen species (ROS) plays a critical role in the pathogenesis of atherosclerosis. Therefore, phytochemicals or antioxidants that inhibit the production of ROS have clinical value for the treatment of atherosclerosis. Rhein is one of the most important active components of rh...

journal_title：Molecular medicine reports

authors： Zhong XF,Huang GD,Luo T,Deng ZY,Hu JN

更新日期：2012-05-01 00:00:00

abstract：:Multidrug resistance (MDR) has become a significant challenge in chemotherapeutic treatment of cancer. Quercetin, a naturally occurring flavonoid, has been found to possess anti-proliferative, anti-inflammatory and immunoregulatory bioactivities. The present study was performed to examine the effect of quercetin on hu...

journal_title：Molecular medicine reports

authors： Chen FY,Cao LF,Wan HX,Zhang MY,Cai JY,Shen LJ,Zhong JH,Zhong H

更新日期：2015-01-01 00:00:00

abstract：:The sonic hedgehog (SHH) morphogen regulates cell differentiation and controls a number of genes during renal morphogenesis. To date, the effects of SHH on fibroblast growth factors (Fgfs) in embryonic kidney development remain unclear. In the present study, explants of BALB/c mouse embryonic kidney tissues were used ...

journal_title：Molecular medicine reports

authors： Chen X,Hou XM,Fan YF,Jin YT,Wang YL

更新日期：2016-10-01 00:00:00

abstract：:Extracellular potassium homeostasis is dependent on the activity of potassium channels, which are expressed on the apical membrane of epithelial tubular cells. The renal outer medullary potassium channel (ROMK) is considered to be the major route for potassium transport into the tubule lumen. Hepatocyte growth factor ...

journal_title：Molecular medicine reports

authors： Kato T,Oka K,Nakamura T

更新日期：2018-01-01 00:00:00