The genetic basis for elite running performance.

Abstract:

:The dominance of East African distance runners and sprinters of West African origin invites discussion around the contribution of genetic and lifestyle factors to performance. In this review, we focus on the genetic basis for performance. Previous research associating candidate genes such as ACE and ACTN3 to endurance and sprint performance in Caucasian populations has not been replicated in African populations. This may be influenced by numerous factors, including small sample sizes, comparisons across different ethnic populations and problems identifying appropriate control groups. Conceptually, these failures reveal the complex polygenic nature of physiology and performance, and the erroneous application of a candidate gene approach to more genetically diverse African populations. We argue that research has in fact established a role for genes in performance, and that the frequency, rather than the prevalence, of favourable genetic variants within certain populations may account for the performance dominance in these populations.

journal_name

Br J Sports Med

authors

Tucker R,Santos-Concejero J,Collins M

doi

10.1136/bjsports-2013-092408

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

545-9

issue

9

eissn

0306-3674

issn

1473-0480

pii

47/9/545

journal_volume

47

pub_type

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