Abstract:
BACKGROUND:Reduced cardio-vascular health has been found in patients suffering from alcohol dependence. Low cardio-respiratory fitness is an independent predictor of cardio-vascular disease. METHODS:We investigated physical fitness in 22 alcohol-dependent patients 10 days after acute alcohol withdrawal and compared results with matched controls. The standardized 6-min walk test (6 MWT) was used to analyze the relationship of autonomic dysfunction and physical fitness. Ventilatory indices and gas exchanges were assessed using a portable spiroergometric system while heart rate recordings were obtained separately. We calculated walking distance, indices of heart rate variability and efficiency parameters of heart rate and breathing. In addition, levels of exhaled carbon monoxide were measured in all participants to account for differences in smoking behaviour. Multivariate analyses of variance (MANOVA) were performed to investigate differences between patients and controls with regard to autonomic and efficiency parameters. RESULTS:Patients walked a significantly shorter distance in comparison to healthy subjects during the 6 MWT. Significantly decreased heart rate variability was observed before and after the test in patients when compared to controls, while no such difference was observed during exercise. The efficiency parameters indicated significantly reduced efficiency in physiological regulation when the obtained parameters were normalized to the distance. DISCUSSION:The 6 MWT is an easily applied instrument to measure physical fitness in alcohol dependent patients. It can also be used during exercise interventions. Reduced physical fitness, as observed in our study, might partly be caused by autonomic dysfunction, leading to less efficient regulation of physiological processes during exercise.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Herbsleb M,Schulz S,Ostermann S,Donath L,Eisenträger D,Puta C,Voss A,Gabriel HW,Bär KJdoi
10.1016/j.drugalcdep.2013.03.016subject
Has Abstractpub_date
2013-10-01 00:00:00pages
505-12issue
3eissn
0376-8716issn
1879-0046pii
S0376-8716(13)00111-7journal_volume
132pub_type
杂志文章abstract::A single dose of ethanol has been shown to affect both striatal and hippocampal high-affinity choline uptake. This effect is probably mediated through effects of ethanol on acetylcholine release. Choline uptake has also been shown to be altered in ethanol-dependent animals, and these effects may be coupled to alterat...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(79)90005-x
更新日期:1979-05-01 00:00:00
abstract::The present study evaluates the efficacy of a brief intervention for cannabis users. A randomized controlled trial compared 3 conditions: 4 weekly individual sessions of motivational interviewing and relapse prevention over 1 month (1MIRP); the same 4 sessions over 3 months (3MIRP), and delayed treatment control (DTC)...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2007.02.019
更新日期:2007-10-08 00:00:00
abstract:BACKGROUND:Low socioeconomic status (SES) has been associated with lower alcohol consumption, but also with heavier drinking. To explain this contradictory relationship, we examined SES differences in drinking patterns from an age-period-cohort (APC) perspective. METHODS:Data are from seven waves of the U.S. National ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2017.12.046
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Known most commonly in the U.S. as "hookah," waterpipe tobacco smoking appears to be growing among college students. Despite beliefs that waterpipe use is safer than cigarette smoking, research to date (albeit limited) has found health risks of waterpipe smoking are similar to those associated with cigarette...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2011.01.018
更新日期:2011-05-01 00:00:00
abstract::The current study explored the judgments individuals with Substance Use Disorders (SUDs) make regarding the authenticity of enjoyment smiles and masking smiles containing traces of negative emotions. Accuracy at identifying the masked negative emotions were also examined. Eye-movements were recorded to observe relatio...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.107842
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Respondent driven sampling (RDS) and incentivized snowball sampling (ISS) are two sampling methods that are commonly used to reach people who inject drugs (PWID). METHODS:We generated a set of simulated RDS samples on an actual sociometric ISS sample of PWID in Vilnius, Lithuania ("original sample") to asse...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2013.11.020
更新日期:2014-02-01 00:00:00
abstract::A sample of 175 individuals were interviewed and divided in three subgroups of couples: (1) the husband was in an Anonymous Alcoholics program, (2) the husband had been diagnosed as alcoholic and (3) the husband had a regular pattern of high alcohol consumption. In personal interviews by specialized personnel the foll...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(88)90016-6
更新日期:1988-12-01 00:00:00
abstract::This paper provides a detailed analysis of the 2-year outcomes for 351 drug misusers allocated on an intention-to-treat basis to methadone maintenance or methadone reduction treatments. Both groups showed substantial reductions in their use of illicit drugs and in other outcome areas. However, whereas most methadone m...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(00)00211-8
更新日期:2001-05-01 00:00:00
abstract::This college-based study compared nonmedical users of prescription stimulants to other types of drug users regarding drug use related problems. A Web survey was self-administered in 2005 by a probability sample of 3639 full-time undergraduate students (68% response rate) at a large public Midwestern 4-year university ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2007.05.010
更新日期:2007-11-02 00:00:00
abstract:BACKGROUND:Methadone maintenance therapy (MMT) is an efficacious form of medication assisted treatment for opioid use disorder (OUD), yet many individuals on MMT relapse. Chronic pain and deficits in positive affective response to natural rewards may result in dysphoria that fuels opioid craving and promotes relapse. A...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2019.07.007
更新日期:2019-10-01 00:00:00
abstract::In the search for clinical and biological variables that may predict relapse of alcohol dependent patients after detoxification, we followed up for 1 year male patients that had undergone successful detoxification. The patients had been tested earlier during their usual alcohol consumption and immediately after detoxi...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(01)00139-9
更新日期:2001-11-01 00:00:00
abstract:AIM:To determine the relationship between borderline personality disorder (BPD), antisocial personality disorder (ASPD) and harm among current heroin users. DESIGN:Cross-sectional survey. SETTING:Sydney, Australia. PARTICIPANTS:615 current heroin users. FINDINGS:Forty-six percent met criteria for BPD, 71% for ASPD,...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2003.12.002
更新日期:2004-04-09 00:00:00
abstract:BACKGROUND:Adolescents tend to overestimate the prevalence of substance use among their peers and these perceived norms are associated with their current and future use. However, little is known about how perceived norms change over time during middle school, a developmental period when adolescents are at-risk for init...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2013.08.008
更新日期:2013-12-01 00:00:00
abstract::Buprenorphine has been studied extensively since 1978 when it was initially proposed as an alternative to methadone for treatment of opioid dependence. Early work by Jasinski et al., 1978; Mello and Mendelson, 1980; Mello et al., 1982; Mello et al., 1983 and Mendelson et al., 1984 and their colleagues demonstrated bup...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
doi:10.1016/s0376-8716(03)00059-0
更新日期:2003-05-21 00:00:00
abstract:BACKGROUND:Stressful life events (SLEs) play a key role in suicidal behavior among adults with alcohol use disorders (AUD), yet there are meager data on the severity of SLEs preceding suicidal behavior or the timing of such events. METHOD:Patients in residential substance use treatment who made a recent suicide attemp...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2011.07.013
更新日期:2012-01-01 00:00:00
abstract::The use of smoked marijuana as a therapeutic agent is presently a matter of considerable debate in the United States. Many people suffering from a variety of disorders maintain that it is necessary for their adequate treatment. Yet, the evidence to support claims is insufficient for FDA approval. An interim solution i...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(99)00076-9
更新日期:2000-02-01 00:00:00
abstract::Bath salts are designer drugs with stimulant properties that are a growing medical and psychiatric concern due to their widespread availability and use. Although the chemical compounds in the mixtures referred to as "bath salts" vary, many are derivatives of cathinone, a monoamine alkaloid. Cathinones have an affinity...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
doi:10.1016/j.drugalcdep.2013.06.016
更新日期:2013-09-01 00:00:00
abstract::This study examines the problem of effective treatment for alcoholic patients with concurrent psychopathology. The subjects were 131 male veterans admitted to the Coatesville Veterans Administration Medical Center. They remained in an alcohol rehabilitation program at least five days following detoxification and were ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(81)90083-1
更新日期:1981-08-01 00:00:00
abstract:BACKGROUND:Research has indicated associations between risky alcohol consumption and sexual risk behavior, which may in turn present risk of HIV acquisition or transmission. Little is known about social determinants of problematic alcohol use among African American MSM (AA MSM), a risk group disproportionately affected...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2013.10.002
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Patients with schizophrenia have higher rates of smoking (58-88%) than in the general population ( approximately 22%), and are more refractory to smoking cessation. These patients also exhibit numerous neurocognitive deficits, some of which may be ameliorated by cigarette smoking. The neurocognitive benefits...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2009.04.005
更新日期:2009-09-01 00:00:00
abstract::Sleep duration and indices of disturbed sleep, such as night-time waking and day-time sleep, were investigated in amphetamine users following hospital admission and withdrawal from the drug. Compared to controls, the amphetamine group showed an initial period of oversleeping and, towards the end of the first week, the...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(82)90010-2
更新日期:1982-10-01 00:00:00
abstract:BACKGROUND:Cannabidiol, a therapeutic with potential serotonin (5-hydroxytryptamine; 5-HT) 5-HT1A receptor agonist activity, is the second most prevalent cannabinoid in Cannabis after Δ(9)-THC. The extent to which cannabidiol modifies the effects of Δ(9)-THC has not been firmly established, especially with respect to a...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2016.05.016
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVES:The present study investigated the reliability of proxy reports obtained from family members with self-reports on adolescent and parental lifetime and current smoking status. METHODS:Data were assessed from 416 families, consisting of both biological parents and two adolescent siblings aged 13-17 years. The...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2005.11.026
更新日期:2006-09-01 00:00:00
abstract::Drug dependence units (DDUs) form the cornerstone of government policy response to problem drug taking. Yet we know surprisingly little about the facilities that they can provide and what treatment policies they adopt. This paper constitutes a modest attempt to fill some of the gaps in our knowledge and points to the ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(85)90037-7
更新日期:1985-05-01 00:00:00
abstract:AIMS:This study investigated the serum levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in a group of chronic ketamine abusers in comparison to healthy controls. The correlations between the serum BDNF, NGF level with the subjects' demographic, pattern of ketamine use were also examined....
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2014.06.043
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:This study examined factors associated with marijuana use initiation among never users, prior-to-past year user who return to use, and users who continue use over a 12-month follow-up period. METHODS:Two waves (W1 and W2) of the Population Assessment of Tobacco and Health (PATH) Study provided data (N=26,20...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2017.10.006
更新日期:2018-01-01 00:00:00
abstract::Recent studies implied a possible involvement of the opioid system in the central nervous system (CNS) effects of cocaine. The present study was undertaken to determine specific alterations in opioid receptor binding following repeated exposure of guinea pigs to cocaine. Animals were treated with either saline or coca...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(93)90033-m
更新日期:1993-06-01 00:00:00
abstract::Buprenorphine's clinical utility as an opioid dependence pharmacotherapy may be enhanced with less-than-daily dosing. This study assessed opioid withdrawal after an acute 72 h dose omission in buprenorphine-maintained patients (8 mg/day s.l.). Eight outpatients required to remain free of opioids, cocaine and benzodiaz...
journal_title:Drug and alcohol dependence
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0376-8716(97)01347-1
更新日期:1997-04-14 00:00:00
abstract:BACKGROUND:We measured associations between parental incarceration and STI/HIV-related drug use and sex risk, assessing differences by race, age at first parental incarceration, and potential mediators of the relationship. METHODS:We used Waves I (adolescence), III (young adulthood), and IV (adulthood) of the National...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2017.11.006
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVES:Point-of-care drug checking services, wherein individuals can check the content and purity of their drugs, have emerged as a public health intervention to address the fentanyl crisis; however, there have been no rigorous evaluations of the technologies against reference standard laboratory techniques. METHO...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.108006
更新日期:2020-07-01 00:00:00