Abstract：
:The phase III, multicenter, randomized, placebo-controlled PreCISe trial assessed glatiramer acetate (GA) effects in patients with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS). To assess the neuroprotective effect of GA in a subset of patients in the PreCISe trial, we used proton magnetic resonance spectroscopy (MRS) to measure N-acetylaspartate (NAA), a marker of neuronal integrity, in a large central volume of brain. Thirty-four CIS patients randomized to GA 20 mg/day (n = 19) SC or placebo (n = 15) were included. Patients who relapsed (developed clinically definite MS [CDMS]) were removed from the substudy. NAA/creatine (NAA/Cr) ratios were compared between GA-treated and placebo-treated patients. Twenty patients with CIS had not converted to CDMS and were still in the double-blind phase of the trial at 12 months of follow-up. Paired changes in NAA/Cr differed significantly in patients treated with GA (+0.14, n = 11) compared with patients receiving placebo (-0.33, n = 9, p = 0.03) at 12 months, consistent with a neuroprotective effect of GA in vivo. Patients with CIS who received GA showed improvement in brain neuroaxonal integrity, as indicated by increased NAA/Cr, relative to comparable patients treated with placebo, who showed a decline in NAA/Cr consistent with findings from natural history studies.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Arnold DL,Narayanan S,Antel Sdoi
10.1007/s00415-013-6903-5subject
Has Abstractpub_date
2013-07-01 00:00:00pages
1901-6issue
7eissn
0340-5354issn
1432-1459journal_volume
260pub_type
杂志文章,多中心研究,随机对照试验abstract：:Leukocyte recruitment and inflammatory response play an important patho-physiologic role after cerebral ischemia. This study aimed to evaluate whether leukocyte adhesion molecules can predict clinical outcome in patients after ischemic stroke. We prospectively examined serial changes in p-selectin glycoprotein ligand-...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-5117-3
更新日期：2009-08-01 00:00:00
abstract：:The SOX10 transcription factor is involved in development of neural crest derivatives and fate determination in glial cells. SOX10 mutations have been found in patients with intestinal aganglionosis and depigmentation with deafness (Waardenburg-Hirschsprung). Associated neurological signs have been reported in some ca...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150170159
更新日期：2001-06-01 00:00:00
abstract：:Little is known about the pattern of subacute cognitive domain impairments after ischaemic stroke, nor the temporal evolution of such impairments. Our objective was to investigate the pattern of cognitive impairment in different neuropsychological domains up to a year after ischaemic stroke. We included prospectively ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-012-6625-0
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:The symptomatic treatment of myotonia and myalgia in patients with dystrophic and non-dystrophic myotonias is often not satisfactory. Some patients anecdotally report symptoms' relief through consumption of cannabis. METHODS:A combination of cannabidiol and tetrahydrocannabinol (CBD/THC) was prescribed as c...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09593-6
更新日期：2020-02-01 00:00:00
abstract：:We report a case of polycythemia vera with chorea in which the brain metabolism and dopamine system were investigated using 2-[(18)F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) and (99m)Tc-labeled tropane dopamine transporter ((99m)Tc-TRODAT-1) single photon emission computed tomography (SPECT). Al...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6069-y
更新日期：2011-11-01 00:00:00
abstract：:Gait variability has potential utility as a predictive measure of dysfunction in Parkinson's disease (PD). Current understanding implicates non-dopaminergic pathways. This study investigated the explanatory characteristics of gait variability in PD on and off medication under single and dual task conditions. Fifty peo...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5789-8
更新日期：2011-04-01 00:00:00
abstract：:The use of a dopamine agonist with a long duration of action has theoretical advantages in attempting to reduce the motor fluctuations in Parkinson's disease. We report the results of a double-blind controlled study of adding cabergoline, an ergot derivative with potent long-lasting high affinity for the D2 receptor, ...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00878534
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system. The treatment of MS has always been a focus of neurological research. To date, the US Food and Drug Administration has approved 15 medications for modifying the course of multiple sclerosis. In this study, we exami...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-019-09395-w
更新日期：2020-12-01 00:00:00
abstract：:Using high-performance liquid chromatography, adrenoleukodystrophy (ALD) and adrenomyeloneuropathy (AMN) were diagnosed by the analysis of fatty acids in sphingomyelin. The analytical method was simple, sensitive and accurate. In ALD and AMN patients, very long chain fatty acids (C26:0, C25:0 and C24:0 on the base of ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313696
更新日期：1983-01-01 00:00:00
abstract：:Cortical tubers are very common in tuberous sclerosis complex (TSC) and widely vary in size, appearance and location. The relationship between tuber features and clinical phenotype is unclear. The aim of the study is to propose a classification of tuber types along a spectrum of severity, using magnetic resonance imag...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5535-2
更新日期：2010-08-01 00:00:00
abstract：:A patient with an infarct limited to the paramedian thalamus and upper mesencephalon on the right side suffered a conjugate upgaze palsy associated with a monocular paresis of downward gaze in the ipsilateral eye (vertical "one-and-a-half" syndrome). This paresis involved tonic and phasic components. Vertical oculocep...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313651
更新日期：1984-01-01 00:00:00
abstract：:Evidence of a significant improvement of IFNB-1b in clinical severity in the older population with RRMS has not been established so far. The aim of this exploratory post hoc analysis of the 250 mcg IFNB-1b group of the BEYOND study is to compare the efficacy and safety of older versus younger patients using a cut-off ...
journal_title：Journal of neurology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00415-013-6888-0
更新日期：2013-07-01 00:00:00
abstract：:Intravenous immunoglobulins (IVIg) are effective for treating chronic inflammatory demyelinating polyneuropathy (CIDP), although treatment needs are variable and need to be individualized. Dose and frequency requirements are not currently predictable in advance. In Guillain-Barré syndrome, IVIg interpatient pharmacoki...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-6938-7
更新日期：2013-08-01 00:00:00
abstract：:Multi-modality evoked potentials and computed cranial tomography (CT) were performed in ten patients with Wilson's disease to determine if any of these studies would correlate reliably with neurologic status. While all four patients with CT abnormality had neurologic signs, two additional patients with neurologic find...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314035
更新日期：1985-01-01 00:00:00
abstract：BACKGROUND:The vegetative state, also known as the unresponsive wakefulness syndrome, is one of the worst possible outcomes of acquired brain injury and confronts rehabilitation specialists with various challenges. Emergence to (minimal) consciousness is classically considered unlikely beyond 3-6 months after non-traum...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09542-3
更新日期：2019-12-01 00:00:00
abstract：:Brain metastases occur in 20-40% of patients with cancer and their frequency has increased over time. Lung, breast and skin (melanoma) are the commonest sources of brain metastases, and in up to 15% of patients the primary site remains unknown. After the introduction of MRI, multiple lesions have outnumbered single le...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-002-0870-6
更新日期：2002-10-01 00:00:00
abstract：:The aim of this study was to assess the cognitive functions of patients with spinocerebellar ataxia type 6 (SCA6). We examined 13 patients with genetically confirmed SCA6 and 13 healthy control subjects matched for age, years of education, global cognitive status, and intellectual ability. We administered verbal memor...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-016-8344-4
更新日期：2017-02-01 00:00:00
abstract：:We recently reported findings that loss of cortical acetylcholinesterase (AChE) activity is greater in parkinsonian dementia than in Alzheimer's disease (AD). In this study we determined cognitive correlates of in vivo cortical AChE activity in patients with parkinsonian dementia (PDem, n = 11), Parkinson's disease wi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0971-0
更新日期：2006-02-01 00:00:00
abstract：:We performed the first population-based case-control study on clinical risk factors and drug exposure in Guillain-Barré syndrome (GBS). Sixty patients with GBS were collected through an incidence survey performed in the Emilia-Romagna region of northern Italy. GBS patients were compared with 109 hospital controls (HC)...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050504
更新日期：1999-11-01 00:00:00
abstract：:This review summarizes recent findings from clinical trials regarding the prevention of stroke and translates these into therapeutic guidelines. A distinction is made between patients with previous cerebrovascular disease and those without, and between patients with and those without atrial fibrillation. Although the ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s004150050450
更新日期：1999-09-01 00:00:00
abstract：:A double-blind, placebo-controlled multicentre study was carried out to evaluate the efficacy and tolerability of 100, 200 and 300 mg sumatriptan, a selective 5-hydroxytryptamine (5-HT)1-like receptor agonist, given in an oral dispersible form in the acute treatment of migraine attacks. A total of 1130 patients were r...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF01642909
更新日期：1991-01-01 00:00:00
abstract：:The posterior reversible encephalopathy syndrome (PRES) is a neurological disorder of (sub)acute onset characterized by varied neurological symptoms, which may include headache, impaired visual acuity or visual field deficits, disorders of consciousness, confusion, seizures, and focal neurological deficits. In a major...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-016-8377-8
更新日期：2017-08-01 00:00:00
abstract：:Thirteen patients with subacute sclerosing panencephalitis (S.S.P.E.) at different stages of the disease were admitted for transfer factor treatment. The transfer factor was prepared from non-selected blood bank donors. The activity of the transfer factor was tested in patients with diseases other than S.S.P.E. and wa...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00312462
更新日期：1975-12-02 00:00:00
abstract：:It is now 10 years since the first report of mutations in the presenilin genes that were deterministic for familial autosomal dominant Alzheimer's disease. The most common of these mutations occurs in the presenilin-1 gene (PSEN1) located on chromosome 14. In the ensuing decade, more than 100 PSEN1 mutations have been...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-005-0019-5
更新日期：2006-02-01 00:00:00
abstract：:The article The immediate impact of the COVID‑19 pandemic on motor neuron disease services and mortality in Scotland, written by Stella A. Glasmacher, Juan Larraz, Arpan R. Mehta, Patrick K. A. Kearns, Michael Wong, Judith Newton, Richard Davenport, George Gorrie, Ian Morrison, Javier Carod Artal, Siddharthan Chandran...
journal_title：Journal of neurology
pub_type： 已发布勘误
doi：10.1007/s00415-020-10256-0
更新日期：2020-10-20 00:00:00
abstract：:The Richards-Rundle syndrome (RRS) is characterized by hearing loss, mental deterioration, ataxia, primary hypogonadism and autosomal recessive transmission. In a sibship of six members we found two sisters with RRS together with baldness, impaired GH and PRL secretion after stimulation and different degrees of impair...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313645
更新日期：1984-01-01 00:00:00
abstract：:The occurrence of spontaneous internal carotid or vertebral artery dissection after childbirth remains rare. To our knowledge, seven cases of arterial dissection in the postpartum period have been described in the literature as single case reports. We report four additional cases of internal carotid and vertebral arte...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s004150050437
更新日期：1999-08-01 00:00:00
abstract：:Non-motor symptoms (NMS) of Parkinson's disease (PD) have only recently been increasingly recognized for their impact on a patient's quality of life. In this study, we applied the validated, comprehensive self-completed NMS questionnaire for PD (NMS Quest) to 101 patients with young-onset PD (onset between 21 and 45 y...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-012-6600-9
更新日期：2013-01-01 00:00:00
abstract：:Muscle samples obtained in patients with different neuromuscular diseases were stored at 0 degree C for periods of 6-12h and were subsequently frozen for histochemical processing. Compared to reference samples which had been immediately frozen, the individual test sections displayed different degrees of swelling of th...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313934
更新日期：1984-01-01 00:00:00
abstract：:We have investigated how the abnormal head posture and motility in spasmodic torticollis interferes with ecological movements such as combined eye-to-foot whole-body reorientations to visual targets. Eight mildly affected patients and 10 controls voluntarily rotated eyes and body in response to illuminated targets of ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-6937-8
更新日期：2013-08-01 00:00:00
