Abstract：
OBJECTIVE:To evaluate carbonic anhydrase IX (CAIX) expression as an independent prognostic marker for clear cell renal cell carcinoma (ccRCC). With recent smaller studies showing conflicting results, we aimed to update our initial analysis in 2007 with an additional 5-year follow-up. PATIENTS AND METHODS:We provided long-term follow-up of the same cohort used in our 2007 study (730 patients with unilateral, sporadic ccRCC treated surgically between 1990 and 1999). Associations of CAIX expression with RCC death and distant metastases were evaluated using Cox proportional hazards regression models. RESULTS:CAIX was expressed in 708 (97.0%) of the specimens; 163 tumours (22.3%) had low (≤85%) expression and 567 (77.7%) high (>85%) expression. There were 483 deaths and 265 RCC-specific deaths. The median follow-up for the 247 patients still under observation was 13.8 years. Univariately, low CAIX expression was associated with an increased risk of RCC death vs high expression (hazard ratio 1.62; P < 0.001). Low CAIX expression was not statistically significantly associated with RCC death or distant metastases after adjusting for nuclear grade or coagulative tumour necrosis. CONCLUSION:After additional long-term follow-up of our large cohort, our results continue to suggest that CAIX is not an independent prognostic marker for ccRCC.
journal_name
BJU Intjournal_title
BJU internationalauthors
Zhang BY,Thompson RH,Lohse CM,Dronca RS,Cheville JC,Kwon ED,Leibovich BCdoi
10.1111/bju.12075subject
Has Abstractpub_date
2013-06-01 00:00:00pages
1046-53issue
7eissn
1464-4096issn
1464-410Xjournal_volume
111pub_type
杂志文章abstract：OBJECTIVES:To evaluate the level of symptoms of lower urinary tract dysfunction (LUTD) in orphans in institutions, and compare these data with schoolchildren of the same age group who were not institutionalised, as LUTD in children is related to factors such as social isolation and low self-esteem, with other psycholog...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2006.06034.x
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVE:To investigate the utility of a new 'modified-prone' position for treating pre-vesical stones with extracorporeal shock wave lithotripsy (ESWL), usually considered an acceptable and effective treatment for such stones, but for which many different body positions have been used in an attempt to increase its ef...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410x.2003.04619.x
更新日期：2004-02-01 00:00:00
abstract：OBJECTIVE:To develop and test the safety and feasibility of a novel anti-biofilm mechanism configured for wireless capsule endoscopy (WCE) in a sheep bladder model. MATERIALS AND METHODS:A WCE mechanism, designed for long-term bladder monitoring, was developed and introduced into a sheep bladder for 5 months. The tran...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/bju.12040
更新日期：2013-06-01 00:00:00
abstract：UNLABELLED:What's known on the subject? and what does the study add?: As most urologist known, obesity significantly lowers serum PSA levels. So there is some concern about delayed diagnosis of prostate cancer in obese men. In the present study, we found that the accuracy level of PSA for detecting prostate cancer was ...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2012.11766.x
更新日期：2013-08-01 00:00:00
abstract：:OBJECTIVE To analyse the relationship between the number of nocturia episodes and other variables obtained from a bladder diary, with special attention to the duration of sleep, as nocturia is closely related to sleep disorders. PATIENTS, SUBJECTS AND METHODS Between April 2005 and December 2006, 532 participants, inc...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2009.08379.x
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVE:To assess the utility of percentage free/total prostate-specific antigen (f/tPSA) levels for detecting prostate cancer in a prospectively screened population of men with a 'normal' total PSA level. PATIENTS AND METHODS:Men aged 50-65 years were contacted via their general practitioner and invited for prostat...
journal_title：BJU international
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1464-410X.2005.05514.x
更新日期：2005-06-01 00:00:00
abstract：OBJECTIVE:To compare the effectiveness and safety of standard percutaneous nephrolithotomy (sPCNL) and super-mini PCNL (SMP). PATIENTS AND METHODS:A total of 150 patients presenting with renal calculi of <2 cm were randomised to either sPCNL (Group 1) or SMP (Group 2). Randomisation was based on centralised computer-g...
journal_title：BJU international
pub_type： 杂志文章,随机对照试验
doi：10.1111/bju.15144
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVE:To examine the correlation between partial bladder outlet obstruction (PBOO) and bladder carcinogenesis. MATERIALS AND METHODS:Female Wistar rats (6 weeks old) were divided into three groups of 10 each: group 1 was exposed to n-butyl-n-butanol nitrosamine (BBN, a carcinogen) in drinking water for 8 weeks; gr...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2008.08261.x
更新日期：2009-05-01 00:00:00
abstract：OBJECTIVE:To critically review published data on the urogynaecological aspects of female sexual dysfunction (FSD), as FSD is a developing multidisciplinary issue associated with several biological, medical and psychological factors. METHODS:The reported prevalence of FSD is 19-50% and women with lower urinary tract sy...
journal_title：BJU international
pub_type： 杂志文章,评审
doi：10.1111/j.1464-410X.2007.07442.x
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:To investigate in a prospective, observational study whether transperineal prostate biopsy (TPbx) results in patient-reported quality-of-life (QoL) changes from baseline in the first 3-months after TPbx. PATIENTS AND METHODS:Consenting patients completed the 26-item Expanded Prostate cancer Index Composite (...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/bju.13413
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVE:To determine the effect of combined finasteride and flutamide therapy on haemoglobin and haematocrit values in men with advanced prostate cancer. PATIENTS AND METHODS:Nineteen men, previously untreated by hormone therapy, with histologically confirmed adenocarcinoma of the prostate and clinical evidence of a...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1046/j.1464-410x.1999.00844.x
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVE:• To investigate the feasibility of tissue-engineered corpus cavernosum (TECC) with muscle-derived stem cells (MDSCs) as seed cells and determine the growth potential in vivo. MATERIALS AND METHODS:• Acellular corporal collagen matrices (ACCMs) were obtained from adult rabbit penis by a cell removal procedur...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2010.09695.x
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVE:To review time-trends in the use of perioperative chemotherapy and its impact on oncological outcomes in patients with bladder urothelial cancer (UC) at a single tertiary institution. PATIENTS AND METHODS:Using electronic and paper medical records, 89 patients were identified who underwent radical cystectomy...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/bju.12384
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:To review our experience of using the tubularized incised plate (TIP) urethroplasty (useful in the treatment of distal hypospadias) to treat proximal hypospadias. MATERIALS AND METHODS:From March 1997 to March 2000 primary repairs were carried out on 40 boys (mean age 4.5 years) with proximal hypospadias. Af...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1046/j.1464-410x.2000.00966.x
更新日期：2000-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the justification for operative intervention in patients undergoing surgery for benign scrotal pathology, and to assess the associated morbidity. PATIENTS AND METHODS:Consecutive patients in two surgical firms who underwent surgery for benign intrascrotal pathology over a 5-year period were studi...
journal_title：BJU international
pub_type： 杂志文章,多中心研究
doi：10.1046/j.1464-410x.2001.02276.x
更新日期：2001-08-01 00:00:00
abstract：OBJECTIVES:To examine the effect of the dual-action 5alpha-reductase inhibitor dutasteride on benign prostatic hyperplasia (BPH)-specific health status, as measured by the BPH Impact Index (BII), and to identify baseline and treatment risk factors for those most bothered by their BPH symptoms at the end of the protocol...
journal_title：BJU international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1464-410x.2003.04310.x
更新日期：2003-08-01 00:00:00
abstract：:In the last 3 years there has been a dramatic increase in the treatment options for patients with metastatic renal cancer. In addition to the cytokines interferon and interleukin 2, recently approved agents include sorafenib, sunitinib, temsirolimus and bevacizumab. A plethora of agents that are likely to have clinica...
journal_title：BJU international
pub_type： 杂志文章,评审
doi：10.1111/j.1464-410X.2008.07670.x
更新日期：2008-07-01 00:00:00
abstract：OBJECTIVE:To investigate the high circumcision rate in South Korea and its rapid increase in the short period since its introduction. SUBJECTS AND METHODS:From January to December 2000, 5434 South Korean males (or their parents) aged 0-92 years were interviewed in detail about their circumcision status, their age at c...
journal_title：BJU international
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：UNLABELLED:What's known on the subject? and What does the study add? Acute urinary retention (AUR) and catheterization for AUR (AURC) or drainage of the urine is a well established cause of bladder dysfunction. Previously, we reported that the induction of AURC significantly reduced contractile responses to both carbac...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2012.10965.x
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVE:To explore the possibility that allogeneic responses might, by chance, encompass cross-reactive T cell clones specific for neo-antigenic tumour determinants, and thereby activate antitumour immunity; such cross-reactions are well documented for antiviral immunity, and genetic instability in developing cancers...
journal_title：BJU international
pub_type： 临床试验,杂志文章
doi：10.1111/j.1464-410X.2006.06421.x
更新日期：2006-11-01 00:00:00
abstract：OBJECTIVE:To describe a modification of the posterior prone retroperitoneoscopic nephrectomy, which allows the entire operation to be performed through a single instrument port. PATIENTS AND METHODS:With the patient prone, a retroperitoneal working space is created using a custom-made balloon lateral to the sacrospina...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2008.08232.x
更新日期：2009-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the perioperative and pathological outcomes associated with robot-assisted radical prostatectomy (RARP) in morbidly obese men. PATIENTS AND METHODS:Between January 2008 and March 2012, 3041 patients underwent RARP at our institution by a single surgeon (V.P.). In all, 44 patients were considered ...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2013.11798.x
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVES:To model renal function after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). To identify predictors of renal function decline after surgery, thereby allowing the identification of patients likely to be ineligible for cisplatin-based chemotherapy in the adjuvant setting. PATIEN...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/bju.12597
更新日期：2014-11-01 00:00:00
abstract：:We performed a systematic literature review to assess the current status of a totally intracorporeal robot-assisted radical cystectomy (RARC) approach. The current 'gold standard' for radical cystectomy remains open radical cystectomy. RARC has lagged behind robot-assisted prostatectomy in terms of adoption and percei...
journal_title：BJU international
pub_type： 杂志文章,评审
doi：10.1111/bju.12558
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVE:To identify significant prognostic indicators of upper urinary tract (UUT) urothelial carcinoma (UC) and to assess a risk stratification of patients. PATIENTS AND METHODS:We retrospectively analysed data from 162 patients with non-metastatic UC primarily occurring in UUT treated with open nephroureterectomy....
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2008.08134.x
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:To identify, in a retrospective study, possible molecular markers predictive of radioresponsiveness in patients with transitional cell carcinoma (TCC) of the bladder. PATIENTS AND METHODS:Patients with T2-T4a TCC treated with preoperative radiotherapy and cystectomy were included in the study if their cystec...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1046/j.1464-410x.2001.02268.x
更新日期：2001-08-01 00:00:00
abstract：OBJECTIVE:To systematically review the literature regarding clinical outcomes of 180-W XPS GreenLight laser (GL) vaporisation for the treatment of lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH). METHODS:Recent publications were identified in the field of 180-W GL vaporisation for the...
journal_title：BJU international
pub_type： 杂志文章,评审
doi：10.1111/bju.12955
更新日期：2015-10-01 00:00:00
abstract：:The aims of this paper were to review the published literature on the role of HOX genes in the development of the normal prostate gland and in prostate cancer and to discuss the potential role of the HOX family member, Engrailed-2 (EN2), as a diagnostic test of PCa. Hox genes were first described in the fruit fly Dros...
journal_title：BJU international
pub_type： 杂志文章,评审
doi：10.1111/bju.12269
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVE:To determine, using magnetic resonance imaging (MRI), the incidence of retropubic haematoma and any associated clinically significant effects after a xenograft (porcine dermis) sling (XS) or the tension-free vaginal tape (TVT) procedure. PATIENTS AND METHODS:Between October 2003 and March 2004, 24 consecutiv...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2005.05779.x
更新日期：2005-11-01 00:00:00
abstract：:Erectile dysfunction is common in the ageing man and reliable therapies are needed. The pathophysiology of erectile dysfunction in this group mainly includes chronic ischaemia, which triggers the deterioration of cavernosal smooth muscle and the development of corporeal fibrosis. Assessing the ageing man with erectile...
journal_title：BJU international
pub_type： 杂志文章,评审
doi：10.1046/j.1464-410x.2003.04378.x
更新日期：2003-09-01 00:00:00
