Abstract:
:The ocular surface-a continuous epithelial surface with regional specializations including the surface and glandular epithelia of the cornea, conjunctiva, and lacrimal and meibomian glands connected by the overlying tear film-plays a central role in vision. Molecular and cellular events involved in embryonic development, postnatal maturation, and maintenance of the ocular surface are precisely regulated at the level of gene expression by a well-coordinated network of transcription factors. A thorough appreciation of the biological characteristics of the ocular surface in terms of its gene expression profiles and their regulation provides us with a valuable insight into the pathophysiology of various blinding disorders that disrupt the normal development, maturation, and/or maintenance of the ocular surface. This paper summarizes the current status of our knowledge related to the ocular surface development and gene expression and the contribution of different transcription factors to this process.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Swamynathan SKdoi
10.1155/2013/103947subject
Has Abstractpub_date
2013-01-01 00:00:00pages
103947eissn
2090-004Xissn
2090-0058journal_volume
2013pub_type
杂志文章abstract:Methods:A total of 287 consecutive patients diagnosed with congenital SOP and 82 control subjects were included. Congenital SOP patients were grouped according to the presence (present group) or absence (absent group) of the trochlear nerve using thin-section high-resolution MRI of cranial nerves. We developed a comput...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/9476749
更新日期:2020-12-17 00:00:00
abstract:Purpose:To evaluate neurodegeneration in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy and to assess the possible role of systemic vascular complications in retinal changes. Methods:Sixty eyes of 60 patients with DM2 and without any signs of diabetic retinopathy and 60 eyes of 60 healthy co...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/1825819
更新日期:2019-08-07 00:00:00
abstract::Objective. To compare macular thickness (MT) and retinal nerve fiber layers (RNFL) between women with polycystic ovary syndrome (PCOS) and healthy women. Materials and Methods. The study included 45 women with PCOS and 47 ovulatory women undergoing clinical-gynecological and ophthalmic evaluations, including measureme...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/193078
更新日期:2015-01-01 00:00:00
abstract:Purpose:To report the long-term follow-up results of posterior segment intraocular foreign body (IOFB) removal in children and to determine the prognostic factors for visual outcome. Methods:Design: retrospective, noncomparative, interventional case series; a single tertiary care center study. Participants or samples:...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/5861043
更新日期:2018-06-25 00:00:00
abstract:Purpose:To compare the impact of visual field (VF) testing on intraocular pressure (IOP) change trends between healthy subjects and glaucoma patients. Methods:We recruited healthy volunteer subjects who did not have previous ocular diseases and open-angle glaucoma patients who were medically controlled well. IOP in bo...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/7936205
更新日期:2020-07-04 00:00:00
abstract::Objective. The purpose of this study was to examine how patient, physician, and situational factors are associated with the extent to which providers educate patients about glaucoma and glaucoma medications, and which patient and provider characteristics are associated with whether providers educate patients about gla...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2014/238939
更新日期:2014-01-01 00:00:00
abstract::Purpose. To report the 12-month follow-up after big-bubble deep anterior lamellar keratoplasty (DALK) assisted by femtosecond laser that we have called IntraBubble. Methods. A 60 kHz IntraLase femtosecond laser (Abbott Medical Optics) firstly created a 30° angled intrastromal channel to insert the air injection cannul...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2012/264590
更新日期:2012-01-01 00:00:00
abstract::Diabetic retinal complications, including macular edema (DME) and proliferative diabetic retinopathy (PDR), are the leading cause of new cases of blindness among adults aged 20-74. Chronic hyperglycemia, considered the underlying cause of diabetic retinopathy, is thought to act first through violation of the pericyte-...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2012/209538
更新日期:2012-01-01 00:00:00
abstract:Purpose:To identify the clinical characteristics and risk factors for secondary choroidal neovascularization (CNV) in central serous chorioretinopathy (CSC). Methods:In this retrospective study, we included a total of 108 eyes in 106 CSC patients. Group A was defined as patients initially diagnosed with CSC who develo...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/7217906
更新日期:2020-02-07 00:00:00
abstract::Purpose. To evaluate the anterior chamber volume in cataract patients with Swept-Source Optical Coherence Tomography (SS-OCT) and its influencing factors. Methods. Anterior chamber volume of 92 cataract patients was evaluated with SS-OCT in this cross-sectional study. Univariate analyses and multiple linear regression...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/8656301
更新日期:2016-01-01 00:00:00
abstract:Purpose:To report a novel technique of cross-knotted suture basket and to test its effectiveness in large nonmagnetic intraocular foreign body (IOFB) removal. Methods:A 7/0 Vicryl suture was cut in half and cross-knotted, and four ends were introduced into a 23G needle to form a basket. Pig eyes were used to set up th...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/1061462
更新日期:2020-04-25 00:00:00
abstract:Purpose:To analyse the correlation of myopia with physical exercise and sleep habits to explore the possible risk or protective factors of juvenile myopia. Methods:This study was a retrospective cross-sectional study. A total of 1831 students aged 11-18 years from five schools in Qingpu completed questionnaires from 2...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/2670153
更新日期:2020-07-25 00:00:00
abstract:Purpose:To evaluate changes in flow density after the implantation of a trabecular microbypass stent (iStent) in combination with cataract surgery. Methods:A total of 48 eyes of 48 patients, who underwent either cataract surgery alone (cataract group) or cataract surgery with implantation of two iStent inject devices ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/2890357
更新日期:2018-01-31 00:00:00
abstract::LASIK eye surgery has become a very common practice for myopic people, especially those in the military. Sometimes undertaken by people who need to keep a specific medical aptitude, this surgery could be performed in secret from the hierarchy and from the institute medical staff. However, even though the eyes have bee...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2014/762364
更新日期:2014-01-01 00:00:00
abstract::The functional visual acuity test which is the average of the visual acuities measured during a specific time frame (standard, 60 seconds) has been used recently to assess the visual function in various conditions. The availability of a shorter version of the functional visual acuity test promises to be patient friend...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/8950418
更新日期:2019-09-10 00:00:00
abstract:Purpose:Studying the early effect of different extraocular muscle (EOM) surgeries on corneal biomechanics. Subjects and methods:This is a prospective, nonrandomized, interventional study, in which 42 eyes of 29 candidates for EOM surgery for strabismus correction at Cairo university hospitals, aged 14-37 years, were r...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/8072140
更新日期:2018-09-16 00:00:00
abstract:Purpose:Evaluation of the indications, anatomical and functional results, and complications of total penetrating keratoplasty (TPK) in disorders involving whole cornea. Materials and Methods:We analyzed outcomes of the surgical treatment of 47 eyes of 46 patients that underwent TPK. Indications were infectious keratit...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/9580292
更新日期:2018-04-19 00:00:00
abstract::Purpose. To evaluate the relationship between self-reported vision-related quality of life (VRQL) and visual field (VF) loss in people from glaucoma clinics. Methods. A postal survey using the National Eye Institute Visual Function Questionnaire (NEI VFQ-25) was administered to people with a range of VF loss identifie...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/1621640
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To evaluate sequential changes in choroidal thickness at the affected area in patients with acute zonal occult outer retinopathy (AZOOR). METHODS:This retrospective observational case series included 14 affected eyes and 6 unaffected fellow eyes from 10 AZOOR patients with impaired macular area. Using enhanced...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/2371032
更新日期:2017-01-01 00:00:00
abstract:Introduction:To assess long-term efficacy of bimedial rectus tendon elongation with Tutopatch in thyroid-associated orbitopathy (TAO). Materials and Methods:Retrospective chart review of 5 patients with TAO undergoing bimedial rectus recession with Tutopatch tendon elongation between 2009 and 2015. We analyzed horizon...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/1294761
更新日期:2018-07-24 00:00:00
abstract::Purpose. To investigate the local relationship between quantified global-flash multifocal electroretinogram (mfERG) optic nerve head component (ONHC) and visual field defects in patients with glaucoma. Methods. Thirty-nine patients with glaucoma and 30 normal controls were enrolled. The ONHC amplitude was measured fro...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/397495
更新日期:2015-01-01 00:00:00
abstract::Familial exudative vitreoretinopathy (FEVR) is a hereditary ocular disorder characterized by incomplete vascularization/abnormality of peripheral retina. Four of the identified disease-causing genes of FEVR were NDP, FZD4, LRP5, and TSPAN12, the protein coded by which were the components of the Norrin/β-catenin signal...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2019/5782536
更新日期:2019-11-16 00:00:00
abstract:Purpose:To evaluate the clinical classification and characteristics of hereditary optic neuropathy patients in a single center in China. Method:Retrospective case study. Patients diagnosed with hereditary optic neuropathy between January 2014 and December 2015 in the neuro-ophthalmology division in Shanghai Eye and EN...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/6186052
更新日期:2017-01-01 00:00:00
abstract:Purpose:To evaluate the efficacy and safety of MyoRing implantation in eyes with keratoconus managed at a tertiary eye hospital in the Eastern Province of Saudi Arabia. Methods:This one-armed historical cohort study included keratoconus patients operated for MyoRing implant. The cases were assessed before and 6 months...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/2630704
更新日期:2019-08-29 00:00:00
abstract::Purpose. Randomized controlled trial aimed at comparing surgical outcomes in a group of patients suffering from hyperfunction of the inferior oblique (IO) muscle with abnormal head position (AHP). The surgical techniques being compared are Recession and (thread) Controlled Myotomy. Materials and Methods. The group of ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/1725484
更新日期:2016-01-01 00:00:00
abstract::Purpose. This study investigated the effects of oral propolis on the progression of galactose-induced sugar cataracts in rats and the in vitro effects of propolis on high-glucose-induced reactive oxygen species (ROS) and cell death in cultured rat lens cells (RLECs). Methods. Galactose-fed rats and RLECs cultured in h...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/1917093
更新日期:2016-01-01 00:00:00
abstract:Purpose:To investigate whether the risk of subsequent stroke, ischemic stroke, hemorrhagic stroke, and all-cause mortality is increased among retinal vein occlusion (RVO) patients compared to non-RVO patients. Methods:From the entire population of the Taiwan National Health Insurance Research Database (NHIRD) from 200...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/8629429
更新日期:2018-09-09 00:00:00
abstract::Fifty-two eyes of 52 patients with treatment-naïve macular edema associated with perfused branch retinal vein occlusion were retrospectively reviewed. Twenty-seven cases received PRN intravitreal bevacizumab, and 25 cases were treated by PRN intravitreal aflibercept with monthly follow-ups for 12 months. Both afliberc...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/8421940
更新日期:2016-01-01 00:00:00
abstract::Macular pseudoholes (MPHs) and lamellar macular holes (LMHs) have been recently defined according to spectral domain optical coherence tomography (SD-OCT) criteria. A major feature for differentiating an MPH from an LMH remains the loss of foveal tissue. The anatomy of the foveola is peculiar with the macular pigment ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2019/4948212
更新日期:2019-02-10 00:00:00
abstract:Purpose:Activating transcription factor 4 (ATF4) is induced by various stressors. Here, we investigated the expression of ATF4 in the host inflammatory response to Aspergillus fumigatus (A. fumigatus) keratitis. Methods:A. fumigatus keratitis mouse models developed by intrastromal injection as well as corneal epitheli...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/5830202
更新日期:2018-12-13 00:00:00