Hypervariability in a minisatellite 3' of the apolipoprotein B gene in patients with coronary heart disease compared with normal controls.

abstract：:As microsomal triglyceride transfer protein (MTP) is required for the assembly and secretion of apoB-containing lipoproteins by intestinal epithelial cells, the characterization and regulation of MTP in human intestinal cells, CaCo-2, was studied. CaCo-2 cells express MTP mRNA of 4.2 kb and a 97 kDa subunit of MTP pro...

journal_title：Journal of lipid research

authors： Mathur SN,Born E,Murthy S,Field FJ

更新日期：1997-01-01 00:00:00

abstract：:Mice bearing the Ehrlich ascites tumor were fed diets rich in either coconut oil or sunflower oil. From 20 to 40% less lipid was present in the ascites tumor fluid when the mice were fed the sunflower oil diet. This was associated with a reduction in the amount of very low density lipoproteins (VLDL) and high density ...

journal_title：Journal of lipid research

authors： Mathur SN,Spector AA

更新日期：1978-05-01 00:00:00

abstract：:A reproducible cell culture system is described that allows the study of adipose conversion in fibroblast-like cells isolated by collagenase digestion of epididymal and perirenal adipose tissue from male rats weighing 70-200 g. Adipose conversion as measured by lipid accumulation and increase in glycerophosphate dehyd...

journal_title：Journal of lipid research

authors： Wiederer O,Löffler G

更新日期：1987-06-01 00:00:00

abstract：:13C-NMR spectroscopy was used to examine the effect of side chain length on the ionization properties and transmembrane transport rate of 3 alpha,7 alpha-dihydroxy bile acids. When solubilized in taurocholate micelles, [23-13C]nor-chenodeoxycholic acid (nor-CDCA) had a pKa of 6.1, similar to that of CDCA (pKa 6.2), it...

journal_title：Journal of lipid research

authors： Ko J,Hamilton JA,Ton-Nu HT,Schteingart CD,Hofmann AF,Small DM

更新日期：1994-05-01 00:00:00

abstract：:Lipid droplet proteins (LDPs) coat the surface of triglyceride-rich lipid droplets and regulate their formation and lipolysis. We profiled hepatic LDP expression in fatty liver dystrophic (fld) mice, a unique model of neonatal hepatic steatosis that predictably resolves between postnatal day 14 (P14) and P17. Western ...

journal_title：Journal of lipid research

authors： Hall AM,Brunt EM,Chen Z,Viswakarma N,Reddy JK,Wolins NE,Finck BN

更新日期：2010-03-01 00:00:00

abstract：:Niemann-Pick disease, type C (NP-C), often associated with Niemann-Pick disease, type C1 (NPC1) mutations, is a cholesterol-storage disorder characterized by cellular lipid accumulation, neurodegeneration, and reduced steroid production. To study NPC1 function in vivo, we cloned zebrafish npc1 and analyzed its gene ex...

journal_title：Journal of lipid research

authors： Schwend T,Loucks EJ,Snyder D,Ahlgren SC

更新日期：2011-07-01 00:00:00

abstract：:We studied the biogenesis of apolipoprotein B (apoB) in primary hepatocytes isolated from hamster liver, an animal model with striking resemblance to humans in lipoprotein metabolism. Hamster hepatocytes were found to assemble and secrete apoB-containing lipoproteins at a density of VLDL. Intracellular mechanisms of a...

journal_title：Journal of lipid research

authors： Taghibiglou C,Rudy D,Van Iderstine SC,Aiton A,Cavallo D,Cheung R,Adeli K

更新日期：2000-04-01 00:00:00

abstract：:Biliary cholesterol secretion is ordinarily tightly coupled to phosphatidylcholine (PC) secretion. Bile PCs are distinct in composition and predominantly composed of molecular species with 16:0 in the sn-1 position and 18:2 and 18:1 in the sn-2 position. In an attempt to acutely change the composition of biliary PCs a...

journal_title：Journal of lipid research

authors： Robins SJ,Fasulo JM,Robins VF,Patton GM

更新日期：1991-06-01 00:00:00

abstract：:Electrospray ionization mass spectrometry has previously been used to probe qualitative changes in the phospholipid cardiolipin (CL), but it has rarely been used in a quantitative manner. We assessed changes in the amount of individual molecular species of cardiac CL present in a model of congestive heart failure usin...

journal_title：Journal of lipid research

authors： Sparagna GC,Johnson CA,McCune SA,Moore RL,Murphy RC

更新日期：2005-06-01 00:00:00

abstract：:Apolipoprotein E plays a critical role in plasma lipoprotein clearance. Peptide models of a highly conserved, N-terminal domain of this protein have been shown to increase the binding of low density lipoprotein (LDL) to fibroblast cell surfaces independently of the low density lipoprotein receptor. Here we provide dat...

journal_title：Journal of lipid research

authors： Dominguez SR,Miller-Auer H,Reardon CA,Meredith SC

更新日期：1999-04-01 00:00:00

abstract：:Acetyl-L-carnitine is known as a reservoir of activated acetyl units and as a modulator of metabolic function. The objective of this study was to quantify the fate of the acetyl moiety of acetyl-L-carnitine in lipogenic pathways. Lipogenesis was studied in an adipocyte model, differentiated 3T3-L1 cells, and a hepatom...

journal_title：Journal of lipid research

authors： Lligona-Trulla L,Arduini A,Aldaghlas TA,Calvani M,Kelleher JK

更新日期：1997-07-01 00:00:00

abstract：:The activity of rat liver microsomal squalene epoxidase is inhibited effectively by digitonin. Concentrations of 0.8 to 1.2 mg/ml of digitonin cause total inhibition of microsomal (0.75 mg protein/ml) squalene epoxidase either in microsomes that were pretreated with digitonin and subsequently washed and subjected to e...

journal_title：Journal of lipid research

authors： Eilenberg H,Klinger E,Przedecki F,Shechter I

更新日期：1989-08-01 00:00:00

abstract：:Deficiency of lysosomal acid lipase (LAL) leads to either Wolman disease (WD) or the more benign cholesteryl ester storage disease (CESD). To identify the molecular basis of the different phenotypes we have characterised the LAL gene mutations in three new patients with LAL deficiency. A patient with WD was homozygote...

journal_title：Journal of lipid research

authors： Pagani F,Pariyarath R,Garcia R,Stuani C,Burlina AB,Ruotolo G,Rabusin M,Baralle FE

更新日期：1998-07-01 00:00:00

abstract：:The effects of intravenous injection of lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNF) were investigated in cynomolgus monkeys (Macaca fascicularis). Injection of 20 micrograms/kg of LPS from E. coli (serotype 055:B5) into cynomolgus monkeys fed a monkey chow diet caused a twofold increase in plasma tr...

journal_title：Journal of lipid research

authors： Ettinger WH,Miller LD,Albers JJ,Smith TK,Parks JS

更新日期：1990-06-01 00:00:00

abstract：:A glycerophospholipid (1-O-tuberculostearoyl-2-O-palmitoyl-sn-glycero-3-phosphoethanolamine) from Mycobacterium tuberculosis was isolated from the reference strain H37Rv. The molecular structure of this tuberculostearoyl [(R)-10-methyloctadecyl] and palmitoyl containing phosphatidylethanolamine (PE) has been resolved....

journal_title：Journal of lipid research

authors： Ter Horst B,Seshadri C,Sweet L,Young DC,Feringa BL,Moody DB,Minnaard AJ

更新日期：2010-05-01 00:00:00

abstract：:Since spheroidal HDL particles (sHDL) are highly dynamic, molecular dynamics (MD) simulations are useful for obtaining structural models. Here we use MD to simulate sHDL with stoichiometries of reconstituted and circulating particles. The hydrophobic effect during simulations rapidly remodels discoidal HDL containing ...

journal_title：Journal of lipid research

authors： Segrest JP,Jones MK,Catte A

更新日期：2013-10-01 00:00:00

abstract：:3alpha-Hydroxy-5-cholanoic acid (lithocholic acid) and some unidentified acids (one of them perhaps 3-hydroxy-cholest-5-en-26-oic acid) have been detected in the brains of guinea pigs afflicted with experimental "allergic" encephalomyelitis. None of the acids could be identified in comparable amounts of brain tissue f...

journal_title：Journal of lipid research

authors： Naqvi SH,Herndon BL,Kelley MT,Bleisch V,Aexel RT,Nicholas HJ

更新日期：1969-01-01 00:00:00

abstract：:Blood levels of lipoprotein cholesterol and triglycerides (TGs) are highly heritable and are major risk factors for cardiovascular disease (CVD). Approximately 100 lipid-associated loci have been identified in populations of European ancestry. We performed a genome-wide association study of lipid traits in 1,782 Filip...

journal_title：Journal of lipid research

authors： Wu Y,Marvelle AF,Li J,Croteau-Chonka DC,Feranil AB,Kuzawa CW,Li Y,Adair LS,Mohlke KL

更新日期：2013-11-01 00:00:00

abstract：:Selectivity of CDP-choline:diacylglycerol choline phosphotransferase and CDP-ethanolamine:diacylglycerol ethanolamine phosphotransferase for molecular species of diglyceride has been studied in rat brain microsomes in vitro. Diglyceride-labeled microsomes were prepared by incubation with labeled sn-glycerol-3-phosphat...

journal_title：Journal of lipid research

authors： Roberti R,Binaglia L,Porcellati G

更新日期：1980-05-01 00:00:00

abstract：:Bacterial lipopolysaccharides (LPSs or endotoxins) can bind most proteins of the lipid transfer/LPS-binding protein (LT/LBP) family in host organisms. The LPS-bound LT/LBP proteins then trigger either an LPS-induced proinflammatory cascade or LPS binding to lipoproteins that are involved in endotoxin inactivation and ...

journal_title：Journal of lipid research

authors： Dusuel A,Deckert V,Pais de Barros JP,van Dongen K,Choubley H,Charron É,Le Guern N,Labbé J,Mandard S,Grober J,Lagrost L,Gautier T

更新日期：2020-12-15 00:00:00

abstract：:ABCA1 plays a key role in the initial lipidation of apoA-I, which generates circulating HDL cholesterol. Whereas it is known that the transcriptional upregulation of ABCA1 promotes HDL formation and reverse cholesterol transport (RCT), it is not known how the inhibition of ABCA1 protein degradation impacts HDL functio...

journal_title：Journal of lipid research

authors： Huang L,Fan B,Ma A,Shaul PW,Zhu H

更新日期：2015-05-01 00:00:00

abstract：:Apicomplexan parasites are pathogens responsible for major human diseases such as toxoplasmosis caused by Toxoplasma gondii and malaria caused by Plasmodium spp. Throughout their intracellular division cycle, the parasites require vast and specific amounts of lipids to divide and survive. This demand for lipids relies...

journal_title：Journal of lipid research

authors： Dubois D,Fernandes S,Amiar S,Dass S,Katris NJ,Botté CY,Yamaryo-Botté Y

更新日期：2018-06-01 00:00:00

abstract：:In this study, we investigated the hypothesis that regulatory T cells (T(reg)) are involved in the immunomodulatory effects of statins on rheumatoid arthritis (RA) patients. The 12-week study cohort consisted of 55 RA patients and 42 control subjects allocated to either a group treated with atorvastatin (AT) (20 mg/da...

journal_title：Journal of lipid research

authors： Tang TT,Song Y,Ding YJ,Liao YH,Yu X,Du R,Xiao H,Yuan J,Zhou ZH,Liao MY,Yao R,Jevallee H,Shi GP,Cheng X

更新日期：2011-05-01 00:00:00

abstract：:The hepatic synthesis of sterol was measured in the male Mongolian gerbil (Meriones unguiculatus) in vivo following the administration of [3H]water by monitoring the incorporation of radioactivity into digitonin-precipitable sterol. A diurnal rhythm in cholesterol synthesis was exhibited under conditions of ad libitum...

journal_title：Journal of lipid research

authors： Mercer NJ,Holub BJ

更新日期：1981-07-01 00:00:00

abstract：:Bile acids are physiological detergents that generate bile flow and facilitate intestinal absorption and transport of lipids, nutrients, and vitamins. Bile acids also are signaling molecules and inflammatory agents that rapidly activate nuclear receptors and cell signaling pathways that regulate lipid, glucose, and en...

journal_title：Journal of lipid research

authors： Chiang JY

更新日期：2009-10-01 00:00:00

abstract：:Lipogenesis in vitro from acetate-1-(14)C was studied in human preputial skin and abdominal skin. Radioactive lipids were separated by column chromatography on Florisil and by thin-layer chromatography on silica gel. Radioactivity was incorporated chiefly into the triglyceride, sterol, and polar lipid fractions, while...

journal_title：Journal of lipid research

authors： Vroman HE,Nemecek RA,Hsia SL

更新日期：1969-09-01 00:00:00

abstract：:Protein farnesylation is a form of posttranslational modification that occurs in most, if not all, eukaryotic cells. Inhibitors of protein farnesyltransferase (PFTIs) have been developed as anticancer chemotherapeutic agents. Using the knowledge gained from the development of PFTIs for the treatment of cancer, researc...

journal_title：Journal of lipid research

authors： Eastman RT,Buckner FS,Yokoyama K,Gelb MH,Van Voorhis WC

更新日期：2006-02-01 00:00:00

abstract：:In breast cancer, 17β-estradiol (E2) plays critical roles mainly by binding to its canonical receptor, estrogen receptor (ER) α66, and eliciting genomic effects. E2 also triggers rapid, nongenomic responses. E2 activates sphingosine kinase 1 (SphK1), increasing sphingosine-1-phosphate (S1P) that binds to its receptors...

journal_title：Journal of lipid research

authors： Maczis MA,Maceyka M,Waters MR,Newton J,Singh M,Rigsby MF,Turner TH,Alzubi MA,Harrell JC,Milstien S,Spiegel S

更新日期：2018-12-01 00:00:00

abstract：:Glycosyl hydrolases (GHs) are carbohydrate-active enzymes that hydrolyze a specific β-glycosidic bond in glycoconjugate substrates; β-glucosidases degrade glucosylceramide, a ubiquitous glycosphingolipid. GHs are grouped into structurally similar families that themselves can be grouped into clans. GH1, GH5, and GH30 g...

journal_title：Journal of lipid research

authors： Ben Bdira F,Artola M,Overkleeft HS,Ubbink M,Aerts JMFG

更新日期：2018-12-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the United States and, indeed, worldwide. It has become a global public health issue. In the United States, the prevalence in the general population is estimated at approximately 20%, while that in the morbidly obese population at approximate...

journal_title：Journal of lipid research

authors： Erickson SK

更新日期：2009-04-01 00:00:00