Abstract:
AIM OF THE PAPER:Comparison of conventional cytodiagnostics with molecular identification of DNA and mRNA HPV HR, immunocytochemical test for suppressor protein P16 and nuclear Ki 67 to detect cervical pathology screening of the division to LG SIL and HG SIL. MATERIAL:630 Pap smears were taken from women with suspected cervical pathology were submitted for analysis, together with 558 smears for the presence of DNA HPV HR, 421 swabs for the presence of mRNA HPV HR, 86 swabs for the presence of suppressor protein P16 and nuclear Ki 67. In all of the women standard colposcopy with biopsy and endocervical abrasion were performed. METHOD:The study used a classic cytological smear taken on the slide, rated in accordance with TBS classification, colposcopy implemented in accordance with the guidelines of the International Federation of Cervical Pathology and Colposcopy from 2003, molecular diagnostic tests based on identifying DNA, mRNA HPV HR and immunocytochemistry diagnostic test--CINtecPLUS. RESULTS:The sensitivity of Pap test identification of CIN 2+ was of 85% and specificity of 23%. Indicators PPV and NPV were respectively 39% and 72%. The accuracy of cytology reached a level of 46%. DNA HPV HR test obtained 91% sensitivity and 33% specificity of the diagnosis of CIN 2+. Its accuracy was 54%. The value of PPV and NPV for molecular diagnostics was respectively 43% and 87%. For mRNA HPV HR test sensitivity of the method was 79%, the specificity was 67%. CINTecPLUS test achieved 100% sensitivity and 67% specificity in the diagnosis of CIN 2+. CONCLUSIONS:1. Conventional cytodiagnostics are inferior in terms of both sensitivity and specificity of molecular test for DNA, mRNA HPV HR and immunocytochemical test for detecting of LG SIL and HG SIL. 2. Immunocytochemical technique shows maximum sensitivity and high specificity of detection of actual precancerous stages--CIN 2+.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Rokita W,Kedzia W,Pruski D,Friebe Z,Nowak-Markwitz E,Spaczyński R,Karowicz-Bilińska A,Spaczyński Msubject
Has Abstractpub_date
2012-12-01 00:00:00pages
894-8issue
12eissn
0017-0011issn
2543-6767journal_volume
83pub_type
杂志文章abstract:BACKGROUND:Ductus venosus is the fetal blood vessel connecting the abdominal portion of the umbilical vein with the inferior vena cava. Numerous studies have confirmed the important role of this vessel in fetal circulation. There are, however cases when finding the ductus venosus during an ultrasound examination is imp...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:10.17772/gp/1623
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVES:Dynamic development of prenatal diagnostics is mostly directed towards search for non-invasive screening. The main role of the screening methods is to select high-risk fetal aneuploidy group of pregnant women. The base for the prenatal screening in modern obstetrics is ultrasound scanning. DESIGN:The aim of...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the safety, feasibility, and effectiveness of transvaginal myomectomy surgery. MATERIAL AND METHODS:We conducted a retrospective study in Shengjing Hospital of China Medical University. In all, 138 patients underwent transvaginal myomectomy from March 2009 to March 2019...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:10.5603/GP.2019.0106
更新日期:2019-01-01 00:00:00
abstract:DESIGN:The aim of our study was estimation of frequency of occurrence endometriosis at girls operated from different indications, research of predisposing factors and estimation of selected biophysical parameters. MATERIAL AND METHODS:Material determined 14 of patients in 13 to 21 years old of life operated on account...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract::The system of cervical carcinoma prophylaxis introduced in 1974 in the Province of Szczecin based on obligatory obtaining of cytological smears at least one in a year from each woman coming for gynaecological examination and obligatory presentation of the result of this examination by each woman going for sanatorium t...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1989-07-01 00:00:00
abstract::Accurate diagnosis and proper monitoring of cancer patients remain important obstacles for successful cancer treatment. The search for cancer biomarkers is carried out in order to quickly identify tumor cells and predict treatment response, ultimately leading to a favorable therapeutic outcome. One such prognostic mar...
journal_title:Ginekologia polska
pub_type: 杂志文章,评审
doi:
更新日期:2012-07-01 00:00:00
abstract::Between 1994-1999 at the Department for Diagnosis of Congenital Malformations at the PPMH Institute there were ultrasound and echocardiography examinations performed in 40 fetuses with Down Syndrome. In our study most of the cases come from low risk groups of pregnant women. Congenital heart defects (AV-canal in 13/18...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVES:The aim of our study was clinical analysis of patients operated with squamous cell carcinoma of the uterine cervix. MATERIALS AND METHODS:Between 1972 and 1991 at the 2nd Department of Obstetrics and Gynecology Medical University of Gdańsk 687 total hysterectomies in Wertheim-Meigs method were performed in ...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the outcomes of treatment in patients suffering from recurrent spontaneous abortion and antiphospholipid syndrome. MATERIALS AND METHODS:148 observed women suffering from recurrent abortion with presence of lupus anticoagulant antibodies (LA) and/or high moderate concentration of anticardiolipin ...
journal_title:Ginekologia polska
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2003-10-01 00:00:00
abstract::The authors evaluated the influence of NAD, NADP, G-6-P and G-6-PDH on the synthesis of steroid hormones in the interstitial gland of the rat. The animals were killed by decapitation, and sections of the nucleus weighing altogether 20 mg were incubated with NAD (0.4 mM), NADP (0.4 mM), G-6-P (3.5 mM) and G-6-PDH (2 j....
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1989-05-01 00:00:00
abstract::In the group of 213 women with diagnosed endometriosis, after the histological analysis of the samples obtained during surgical procedure the following factors have been determined: the character and frequency of complaints, prevalence of the disease depending on the age of patients, it's localisation, coexistence wit...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract:OBJECTIVES:Human papillomavirus (HPV) ranks the first cause of cervical cancer. Cervical cancer has high prevalence rates in women around the world. The HPV-E7 oncoprotein is expressed in cervical cancer and is a target of developing immunotherapies against HPV-associated tumors. However, the antigenicity of this prote...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:10.5603/GP.2020.0055
更新日期:2020-01-01 00:00:00
abstract::Maldevelopment of the müllerian ducts occurs in a variety of forms, and each anomaly is distinctive. Nevertheless, some generalizations can be made. A comprehensive preoperative evaluation of patients with suspected uterovaginal malformations is essential, but a clear understanding of the particular anomaly may not be...
journal_title:Ginekologia polska
pub_type: 杂志文章,评审
doi:
更新日期:2005-11-01 00:00:00
abstract::Scientific journals are ranked and evaluated to measure their relative importance and influence on science within a specific field. One of the tools most widely used to evaluate and compare journals is the Thomson Reuters Impact Factor In Poland a specific value of a scientist's Impact Factor is required for academic ...
journal_title:Ginekologia polska
pub_type: 社论
doi:
更新日期:2011-08-01 00:00:00
abstract::Gene therapy is an innovative way of treating genetic disorders, which enables removal or repair of genetic defects. Strategies of gene therapy offer new perspectives in treating cancer diseases. Numerous methods for specifically removing tumor cells are currently used. They can be divided into five main strategies: c...
journal_title:Ginekologia polska
pub_type: 杂志文章,评审
doi:
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:Angiogenesis in malignant tumors is a prognostic factor associated with tumor growth and metastasis. Studies of angiogenesis in breast, prostate and lung cancer showed that neovascularisation correlates with likelihood of metastasis and recurrence. Our study was to evaluate microvessel density as a prognostic...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract::The opinions about the causes of the endometrial carcinoma have changed since 1995, due to molecular biology progress. The findings concerning the recently discovered suppressor PTEN gene localized on the chromosome 10 -10q23.3, the product of which is a specific phosphatase are especially valuable. The loss of the ge...
journal_title:Ginekologia polska
pub_type: 杂志文章,评审
doi:
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVES:According to the literature the frequency of twins is increasing due to technics af assisted reproduction. Many complications of pregnancy and delivery are more likely to develop during multiple pregnancy. DESIGN:Aim of the study was to analyze labour and delivery in multiple pregnancy and assess the neonat...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to test the relationship between maternal serum proinflammatory cytokines level and AFI (amniotic fluid index) in pregnancies complicated by premature rupture of membranes (PROM). MATERIALS AND METHODS:The maternal serum levels of IL-6, IL-1 beta and TNF-alfa were assessed in patient...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract:AIM:The aim of this report is to present data concerning results and complications related to infertility treatment using assisted reproductive technology (ART) and insemination (IUI) in Poland in 2011. MATERIALS AND METHODS:The report was prepared by the Fertility and Sterility Special Interest Group of the Polish Gy...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:10.17772/gp/1770
更新日期:2014-07-01 00:00:00
abstract::The investigation were made of the seasonal occurrence of the upper respiratory tract inflammation and pneumonia probably caused by ch. trachomotis. The immunofluorescence tests of chlamydia trachomatis were done in the blood serum of 1831 children aged from 2 weeks to 6 years hospitalised in Wrocław. The research was...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract:UNLABELLED:The process of carcinogenesis in both types of cervical carcinoma is dependent on the infection of oncogenic types of HPV. HPV infection could be diagnosed on the basis of whether or not the DNA virus in present. In pregnant women the latent-persistent infection easily changes into its active form. This proc...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:The most common and generally accepted methods of breast cysts treatment are fine needle aspiration or surgical excision. None of these methods allow to avoid or decrease number of recurrences. Regarding hormonal disturbances as a main reason for breast cysts also conservative treatment should be given. DES...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVES:Objective was to examine the relationship of obesity, body fat distribution fasting plasma insulin concentrations and triglycerides of pro-thrombotic and fibrinolitics factors in pre and postmenopausal women. MATERIAL AND METHODS:We assessed 24 (13 nonobese and 11 obese) postmenopausal and 44 (15 obese and ...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract::Most pregnant women have little interest in thinking about the prospect of death. Mortality related to the pregnancy itself is rare, occurring in an estimated 1 of every 30 000 deliveries. Although cardiopulmonary arrest rarely occurs in pregnant women, it is important that the health care team knows the appropriate a...
journal_title:Ginekologia polska
pub_type: 杂志文章,评审
doi:
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:Triplet pregnancies have higher perinatal morbidity and mortality rates than singleton pregnancies. In modern perinatology computer cardiotocography is one of the best methods of fetus state assessment. DESIGN:The research was based on computer analysis of cardiotocograph printouts. MATERIALS AND METHODS:T...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2006-10-01 00:00:00
abstract::Two cases of the Meckel-Gruber syndrome were described at two subsequent pregnancies. Suspicion of this syndrome was established by ultrasonography and confirmed by histopathological findings. Both of the pregnancies were terminated by premature induced delivery. ...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::The paper contains the description of the modification of simplified method for caesarean section, based on the Joel-Cohen and Misgav Ladach method. Advantages of the simplified methods are described on the basis of the cited papers. Following stages of procedure are described in details. ...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract::The group of 277 girls treated for vulvovaginitis was investigated. Any objective and subjective factors, which could effect on occurrence of this disease at girls were analysed. Over 2/3 of investigated girls were before menarche, 36.5% were 3-7 years old. Over 30% had urinary tract infections, 10%--tonsillitis. No e...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1993-07-01 00:00:00
abstract::The hysteroscopic evaluation of uterine openings in 23 sterile women was described. The attention was paid to morphological features of obliterated uterine openings. The hysteroscopic examination of structural changes located in uterine openings seems to be a reliable method for evaluation of potency of oviducts. This...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00