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Effects of sesamin on streptozotocin (STZ)-induced NIT-1 pancreatic β-cell damage.

Abstract：

:The protective effect of sesamin (SES) from sesame meal on NIT-1 pancreatic β-cells damaged by streptozotocin (STZ) in vitro was investigated. The cell viability, insulin secretion, the activity of superoxide dismutase(SOD), glutathione peroxidase (GSHpx) and the content of reduced glutathione (GSH) increased significantly when incubated with SES (400, 200 µg mL-1). The content of malondialdehyde (MDA), nitric oxide (NO) production, and the activity of NO synthase (NOS), inducible NOS (iNOS), decreased significantly when incubated with SES. The destructive changes of NIT-1 cells were ameliorated when treated with SES under microscopic observation. These data suggested that SES had obvious protective effect on NIT-1 pancreatic β-cells damaged by STZ, which might be related to its effects of decreasing levels of β-cell-destroying factors such as oxidative stress and NO synthesis.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Lei H,Han J,Wang Q,Guo S,Sun H,Zhang X

doi

10.3390/ijms131216961

subject

Has Abstract

pub_date

2012-12-11 00:00:00

pages

16961-70

issue

12

issn

1422-0067

pii

ijms131216961

journal_volume

13

pub_type

杂志文章

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