Abstract：
:While there is an emphasis on the early glycemic control for its long-term benefits in preventing microvascular complications of diabetes, the biochemical mechanisms responsible for the long-lasting effects are not clearly understood. Therefore the impact of early insulin (EI) versus late insulin (LI) treatment on diabetic sensory neuropathy and cataract in streptozotocin-induced diabetic Wistar male rats were evaluated. EI group received insulin (2.5 IU/animal, once daily) treatment from day 1 to 90 while LI group received insulin from day 60 to 90. Early insulin treatment significantly reduced the biochemical markers like glucose, triglyceride, glycated hemoglobin, thiobarbituric acid reactive substances, advanced glycation end products and ratio of reduced glutathione and oxidized glutathione in diabetic rats. The late insulin treatment failed to resist the biochemical changes in diabetic rats. Diabetic rats developed sensory neuropathy as evidenced by mechanical and thermal hyperalgesia and showed a higher incidence and severity of cataract as revealed by slit lamp examination. Early insulin treatment protected the rats from the development of neuropathy and cataract, but late insulin administration failed to do so. The results demonstrate the benefits of early glycemic control in preventing neuropathy and cataract development in diabetic rats.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Balakumar M,Saravanan N,Prabhu D,Regin B,Reddy GB,Mohan V,Rema M,Balasubramanyam Msubject
Has Abstractpub_date
2013-01-01 00:00:00pages
56-64issue
1eissn
0019-5189issn
0975-1009journal_volume
51pub_type
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journal_title：Indian journal of experimental biology
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doi：
更新日期：1996-07-01 00:00:00
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journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
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journal_title：Indian journal of experimental biology
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doi：
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journal_title：Indian journal of experimental biology
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doi：
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
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journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
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