Abstract:
:Accumulation of non-heme iron in the brain has been proposed as a biomarker of the progressive neuroanatomical and cognitive declines in healthy adult aging. Postmortem studies indicate that iron content and lifespan differences therein are regionally specific, with a predilection for the basal ganglia. However, the reported in vivo estimates of adult age differences in iron content within subcortical nuclei are highly variable. We present a meta-analysis of 20 in vivo magnetic resonance imaging (MRI) studies that estimated iron content in the caudate nucleus, globus pallidus, putamen, red nucleus, and substantia nigra. The results of the analyses support a robust association between advanced age and high iron content in the substantia nigra and striatum, with a smaller effect noted in the globus pallidus. The magnitude of age differences in estimated iron content of the caudate nucleus and putamen partially depended on the method of estimation, but not on the type of design (continuous age vs. extreme age groups).
journal_name
Neuroimagejournal_title
NeuroImageauthors
Daugherty A,Raz Ndoi
10.1016/j.neuroimage.2012.12.040subject
Has Abstractpub_date
2013-04-15 00:00:00pages
113-21eissn
1053-8119issn
1095-9572pii
S1053-8119(12)01226-8journal_volume
70pub_type
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