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Does maintenance CBT contribute to long-term treatment response of panic disorder with or without agoraphobia? A randomized controlled clinical trial.

Abstract：

OBJECTIVE:We examined the possibility that maintenance cognitive behavior therapy (M-CBT) may improve the likelihood of sustained improvement and reduced relapse in a multi-site randomized controlled clinical trial of patients who met criteria for panic disorder with or without agoraphobia. METHOD:Participants were all patients (N = 379) who first began an open trial of acute-phase CBT. Patients completing and responding to acute-phase treatment were randomized to receive either 9 monthly sessions of M-CBT (n = 79) or assessment only (n = 78) and were then followed for an additional 12 months without treatment. RESULTS:M-CBT produced significantly lower relapse rates (5.2%) and reduced work and social impairment compared to the assessment only condition (18.4%) at a 21-month follow-up. Multivariate Cox proportional hazards models showed that residual symptoms of agoraphobia at the end of acute-phase treatment were independently predictive of time to relapse during 21-month follow-up (hazards ratio = 1.15, p < .01). CONCLUSIONS:M-CBT aimed at reinforcing acute treatment gains to prevent relapse and offset disorder recurrence may improve long-term outcome for panic disorder with and without agoraphobia.

journal_name

J Consult Clin Psychol

journal_title

Journal of consulting and clinical psychology

authors

White KS,Payne LA,Gorman JM,Shear MK,Woods SW,Saksa JR,Barlow DH

doi

10.1037/a0030666

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

47-57

issue

1

eissn

0022-006X

issn

1939-2117

pii

2012-29442-001

journal_volume

81

pub_type

杂志文章,多中心研究,随机对照试验

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