Randomized trial of behavioral activation, cognitive therapy, and antidepressant medication in the prevention of relapse and recurrence in major depression.

Abstract:

:This study followed treatment responders from a randomized controlled trial of adults with major depression. Patients treated with medication but withdrawn onto pill-placebo had more relapse through 1 year of follow-up compared to patients who received prior behavioral activation, prior cognitive therapy, or continued medication. Prior psychotherapy was also superior to medication withdrawal in the prevention of recurrence across the 2nd year of follow-up. Specific comparisons indicated that patients previously exposed to cognitive therapy were significantly less likely to relapse following treatment termination than patients withdrawn from medication, and patients previously exposed to behavioral activation did almost as well relative to patients withdrawn from medication, although the difference was not significantly different. Differences between behavioral activation and cognitive therapy were small in magnitude and not significantly different across the full 2-year follow-up, and each therapy was at least as efficacious as the continuation of medication. These findings suggest that behavioral activation may be nearly as enduring as cognitive therapy and that both psychotherapies are less expensive and longer lasting alternatives to medication in the treatment of depression.

journal_name

J Consult Clin Psychol

authors

Dobson KS,Hollon SD,Dimidjian S,Schmaling KB,Kohlenberg RJ,Gallop RJ,Rizvi SL,Gollan JK,Dunner DL,Jacobson NS

doi

10.1037/0022-006X.76.3.468

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

468-77

issue

3

eissn

0022-006X

issn

1939-2117

pii

2008-06469-011

journal_volume

76

pub_type

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