Abstract:
:The transcriptional silencing of one of the female X-chromosomes is a finely regulated process that requires accumulation in cis of the long non-coding RNA X-inactive-specific transcript (Xist) followed by a series of epigenetic modifications. Little is known about the molecular machinery regulating initiation and maintenance of chromosomal silencing. Here, we introduce a new version of our algorithm catRAPID to investigate Xist associations with a number of proteins involved in epigenetic regulation, nuclear scaffolding, transcription and splicing processes. Our method correctly identifies binding regions and affinities of protein interactions, providing a powerful theoretical framework for the study of X-chromosome inactivation and other events mediated by ribonucleoprotein associations.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Agostini F,Cirillo D,Bolognesi B,Tartaglia GGdoi
10.1093/nar/gks968subject
Has Abstractpub_date
2013-01-07 00:00:00pages
e31issue
1eissn
0305-1048issn
1362-4962pii
gks968journal_volume
41pub_type
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