Abstract：
:The stability of two benzisoxazole antipsychotics was determined in vitro in decomposing porcine blood inoculated with bacteria, utilizing a high-performance liquid chromatography with ultraviolet and fluorescence detection method for drug quantitation. Stability experiments for risperidone and paliperidone were conducted at 7, 20 and 37°C for 4 days using sterile and bacterially inoculated porcine blood. The drugs were stable in sterile blood at each temperature and in inoculated blood at 7°C, but degraded significantly in inoculated blood at 20 and 37°C. Complete loss occurred within 2 days when incubated at 37°C. The benzisoxazole-cleaved degradation products for both drugs were identified as 2-hydroxybenzoyl-risperidone and 2-hydroxybenzoyl-paliperidone utilizing liquid chromatography quadrupole-time-of-flight mass spectrometry and accurate mass measurements. The degradation products have been found in postmortem case studies, including one case where risperidone and paliperidone were not detected, indicating complete conversion can occur in situ.
journal_name
J Forensic Scijournal_title
Journal of forensic sciencesauthors
Butzbach DM,Stockham PC,Kobus HJ,Sims DN,Byard RW,Lokan RJ,Walker GSdoi
10.1111/j.1556-4029.2012.02280.xsubject
Has Abstractpub_date
2013-01-01 00:00:00pages
90-100issue
1eissn
0022-1198issn
1556-4029journal_volume
58pub_type
杂志文章abstract：:This work compares epidemiological and sociological data on persons having committed suicide in 2002 and in 2012 through a retrospective study of every suicide case having led to an autopsy at the Institute for Forensic Medicine of Lyon in 2002 and in 2012. The study included sociodemographic data, medical data, and t...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.12888
更新日期：2016-01-01 00:00:00
abstract：:Determination of sex of unknown skeleton remains is the most important step in the identification process. Racial and regional differences in the populations create and maintain specificity in their dimorphic characteristics. Moreover, considering continued secular changes in the population structure, constant revisio...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2011.01885.x
更新日期：2012-01-01 00:00:00
abstract：:Sodium and potassium cyanide are highly toxic, produced in large amounts by the chemical industry, and linked to numerous high-profile crimes. The U.S. Centers for Disease Control and Prevention has identified cyanide as one of the most probable agents to be used in a chemical terrorism event. We investigated whether ...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2011.01946.x
更新日期：2012-01-01 00:00:00
abstract：:Agencies all around the world now use less-lethal weapons with homogeneous missiles such as bean bag or rubber bullets. Contusions and sometimes significant morbidity have been reported. This study focuses on wounds caused by hybrid ammunition with the pathologists' flap-by-flap procedure. Twenty-four postmortem human...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2010.01431.x
更新日期：2010-09-01 00:00:00
abstract：:Although the ability to develop latent fingerprints on paper using heat alone has been noted previously, it has been considered impractical for casework and inferior to other techniques. Here a new refinement of the technique is demonstrated for the high quality development of latent fingerprints on porous surfaces su...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2008.00902.x
更新日期：2009-01-01 00:00:00
abstract：:Short tandem repeat (STR) analysis is increasingly being used in forensic case analysis because of the large number of STR loci in the human genome and their highly polymorphic nature. An automated DNA sequencer using high sensitivity infrared (IR) fluorescence technology was used to detect STR allele patterns from si...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：:The polymerase chain reaction (PCR) method of specific gene amplification was used in casework to synthesize millions of copies of the polymorphic second exon of the human leukocyte antigen (HLA)-DQ alpha (or DQA1) locus from a variety of evidence samples. The HLA-DQ alpha allelic variants in the amplified deoxyribonu...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：:A forensic genotyping panel of 11 tetranucleotide STR loci from the domestic cat was characterized and evaluated for genetic individualization of cat tissues. We first examined 49 candidate STR loci and their frequency assessment in domestic cat populations. The STR loci (3-4 base pair repeat motifs), mapped in the ca...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2005-09-01 00:00:00
abstract：:In developing latent prints on cartridge casings and shotgun shells, multiple chemical processes should be used in order to obtain the best results. In Phase I, this study established an optimal chemical sequence for both Brass and Nickel cartridge casings based on six sequences involving four chemicals: Cyanoacrylate...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2009.01152.x
更新日期：2009-11-01 00:00:00
abstract：:Intercostal and age differences in the sternal rib end morphology of documented female skeletons from Spitalfields and St. Bride's are examined. The morphology was captured using three-dimensional morphometrics and the statistical analyses employed included parametric and nonparametric MANOVA, discriminant analysis, a...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.12047
更新日期：2013-03-01 00:00:00
abstract：:An unusual fatality involving a 26-year-old male who intentionally ingested approximately 10 g of metoprolol is presented. Autopsy findings revealed foreign material in the gastric content with an acute thrombosis of the left anterior descending coronary artery. Microscopic studies showed evidence of an extremely earl...
journal_title：Journal of forensic sciences
pub_type： 杂志文章,评审
doi：
更新日期：1987-09-01 00:00:00
abstract：:Bloodstain pattern analysis (BPA) involves the interpretation of distinct blood patterns found at crime scenes following a violent act. In this paper, we explored for the first time the effects of surface temperatures upon blood impacting a horizontal surface (steel) with its implications in BPA explored. Specific sur...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.12185
更新日期：2013-09-01 00:00:00
abstract：:Maximum length measurement of the tibia has been found to be variable both in description and implementation. Historically, the literature often excludes the intercondylar eminences from the tibia in metric analysis. This paper explores the quantitative effects of inclusion or exclusion of the eminences on the maximum...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2009.01222.x
更新日期：2010-01-01 00:00:00
abstract：:The ability to correctly estimate the sex of skeletal remains is vital in forensic sciences. This article investigates the sexual dimorphism of the human sacro-iliac joint, using geometric morphometric techniques that assess morphological characters better than the traditional approaches for recording outline shapes, ...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2012.02282.x
更新日期：2013-01-01 00:00:00
abstract：:Short tandem repeat (STR) loci amplified by PCR are known as a useful tool for individual identification and paternity testing. Direct PCR amplification from small amounts of whole blood is a rapid and convenient method for population screening for STR and VNTR markers. The allele frequencies of the vWF locus were det...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：:The demographic and toxicological characteristics of deliberate (SUI, n = 50) and accidental (ACC, n = 927) fatal heroin overdose cases were examined. SUI cases were more likely to be female, had lower body mass indices, were more likely to be enrolled in treatment and less likely to have hepatic pathology. The median...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2010.01385.x
更新日期：2010-07-01 00:00:00
abstract：:The authors report on their macro- and microscopy study of bone lesions made by a sharp force instrument (a single blade knife), and a sharp-blunt instrument classified as a chopping weapon (a hatchet). The aim of this work was to attempt to identify the instrument by analyzing the general class characteristics of the...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2005-07-01 00:00:00
abstract：:On the basis of data collection procedures and forms used in various death investigation offices, we developed generic death investigation report forms (DIRFs). One form was designed for documenting information collected by the initial investigator of death, and another form was designed for documenting information co...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：:Anomalous origin of the coronary artery (AOCA) is a rare, but important cause of sudden cardiac death among young athletes. Nine autopsy cases (8 male, 1 female; mean age, 17.9 years; age range, 11-31 years) of sudden death during or just after exercise caused by AOCA were reviewed. The exercises performed at the time...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.13004
更新日期：2016-03-01 00:00:00
abstract：:Although there is considerable literature on grief and grief work, there have been few studies of the grief process in those who have killed someone. This paper reviews the scope of this problem in England and Wales and examines a number of issues in connection with the grieving process in those who have killed but, b...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
abstract：:The authors present the medico-legal investigations and identification after the aircrash of the Airbus A320 upon the Mount Sainte-Odile (France). The identification team comprising investigators from the gendarmerie, forensic pathologists, odontologists, and scientists of the Institute from Legal Medecine rapidly ret...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:Nosocomial infections have become a major issue of public health and lead to an increasing number of suits for damages. We present a rare case of Aspergillus contamination during cardiac surgery, describe the medicolegal investigation, and present the new system for compensation of bodily injury after nosocomial infec...
journal_title：Journal of forensic sciences
pub_type：
doi：10.1111/1556-4029.13328
更新日期：2017-05-01 00:00:00
abstract：:This paper reviews the complex pharmacology of the new class of antidepressant medications exhibiting selective inhibition of serotonin reuptake. The four selective serotonin reuptake inhibitors (SSRIs) considered--fluoxetine, fluvoxamine, sertraline and paroxetine--can result in toxicity and death through contributin...
journal_title：Journal of forensic sciences
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-01 00:00:00
abstract：:Five diesel samples were analyzed by gas chromatography-mass spectrometry (GC-MS) using six GC temperature programs, aiming to investigate the effect of temperature program on association and discrimination of the samples. Temperature programs varied by ramp rate and incorporated one- or two-step temperature ramps. Pe...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2009.01234.x
更新日期：2010-01-01 00:00:00
abstract：:Forensic science laboratories perform analyses on a variety of materials using gas chromatography/mass spectrometry (GC/MS). Instruments from different vendors may be used, requiring analysts to be proficient in the use of multiple proprietary software packages for collecting and processing data. There is no standardi...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.12113
更新日期：2013-05-01 00:00:00
abstract：:Dextromethorphan is a commonly encountered antitussive medication which has found additional therapeutic use in the treatment of pseudobulbar disorder and as an adjunct to opiate use in pain management. Dextromethorphan at high doses has phencyclidine-like effects on the NMDA receptor system; recreational use of high ...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2012.02133.x
更新日期：2012-09-01 00:00:00
abstract：:Child abuse pediatricians often carry the stigma that their sole role is to diagnose maltreatment. In reality, child abuse pediatricians use their clinical experience and current evidence-based medicine to make the best medical diagnoses for the children they evaluate. To better understand the legal conclusion of susp...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.14463
更新日期：2020-09-01 00:00:00
abstract：:The current practice in securing the contact traces of chemical substances taken from clothes belonging to a person suspected of manual handling explosives is focused on pockets and cuffs. The outerwear worn by people who had contact with fluorescent powders that simulate explosives and drugs was the subject of this s...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.13385
更新日期：2017-07-01 00:00:00
abstract：:This study describes the testing performed by the Minnesota Forensic Science Laboratory (MFSL) to validate the Amplitype DQA1 and Amplitype Polymarker (PM) PCR Amplification and Typing Kits before implementation for casework. All studies were based on the analysis of mock forensic case samples, which were assembled fr...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1996-11-01 00:00:00
abstract：:The objective of this project was to investigate the trends of changes in the crystal morphology of cocaine in the presence of the common adulterants, caffeine and lidocaine HCl. By performing gold chloride microcrystal tests on samples of cocaine with adulterants at 10, 20, and 50% concentrations, trends in the chang...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2011.01702.x
更新日期：2011-05-01 00:00:00
