Abstract:
:Studies on visually deprived individuals provide one of the most striking demonstrations that the brain is highly plastic and is able to rewire as a function of the sensory input it receives from the environment. In the current paper, we focus on spatial abilities that are typically related to the dorsal visual pathway (i.e., spatial/motion processing). Bringing together evidence from cataract-reversal individuals, early- and late-blind individuals and sight-recovery cases of long-standing blindness, we suggest that the dorsal "spatial" pathway is mostly plastic early in life and is then more resistant to subsequent experience once it is set, highlighting some limits of neuroplasticity.
journal_name
Neural Plastjournal_title
Neural plasticityauthors
Dormal G,Lepore F,Collignon Odoi
10.1155/2012/687659subject
Has Abstractpub_date
2012-01-01 00:00:00pages
687659eissn
2090-5904issn
1687-5443journal_volume
2012pub_type
杂志文章abstract::We have previously reported the crossed-withdrawal reflex in which the rats with nerve injury developed behavioral pain responses of the injured paw to stimuli applied to the contralateral uninjured paw. This reflex indicates that contralateral plastic changes may occur in the spinal cord after unilateral nerve injury...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/438319
更新日期:2015-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common form of dementia in the elderly; important risk factors are old age and inheritance of the apolipoprotein E4 (APOE4) allele. Changes in amyloid precursor protein (APP) binding, trafficking, and sorting may be important AD causative factors. Secretase-mediated APP cleavage pr...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/1892612
更新日期:2017-01-01 00:00:00
abstract::Damage to the visual system can result in (a partial) loss of vision, in response to which the visual system may functionally reorganize. Yet the timing, extent, and conditions under which this occurs are not well understood. Hence, studies in individuals with diverse congenital and acquired conditions and using vario...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/6067871
更新日期:2019-09-03 00:00:00
abstract::Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix (ECM) molecules that compose or interact with PNNs, in the pathophysiology of several psychiatric disorders. Studies on schizophrenia, autism spectrum disorders, mood disorders, Alzheimer's disease, and epilepsy point to the involve...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/9847696
更新日期:2016-01-01 00:00:00
abstract::Sustained activation of NLRP3 inflammasome is closely related to diabetes and stroke. However, it is unknown whether NLRP3 inflammasome plays an essential role in stroke in diabetes. We aim to investigate the effect and the potential mechanism of NLRP3 inflammasome in diabetic mice with cerebral ischemia-reperfusion i...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/9163521
更新日期:2018-04-24 00:00:00
abstract::There is a general consensus that sleep is strictly linked to memory, learning, and, in general, to the mechanisms of neural plasticity, and that this link may directly affect recovery processes. In fact, a coherent pattern of empirical findings points to beneficial effect of sleep on learning and plastic processes, a...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2013/103949
更新日期:2013-01-01 00:00:00
abstract::Studies have shown that, depending on its severity and context, stress can affect neural plasticity. Most related studies focused on synaptic plasticity and long-term potentiation (LTP) of principle cells. However, evidence suggests that following high-frequency stimulation, which induces LTP in principal cells, modif...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2008/194097
更新日期:2008-01-01 00:00:00
abstract::Background. Clinically, electroacupuncture (EA) is the most common therapy for aging-related cognitive impairment (CI). However, the underlying pathomechanism remains unidentified. The aims of this study were to observe the effect of EA on cognitive function and explore the potential mechanism by which EA acts on the ...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8853720
更新日期:2020-11-04 00:00:00
abstract::Prenatal stress (PS) has long-term sequelae for the morphological and functional status of the central nervous system of the progeny. A PS-induced proinflammatory status of the organism may result in an impairment of both hippocampal synaptic plasticity and hippocampus-dependent memory formation in adults. We addresse...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/3152129
更新日期:2019-01-21 00:00:00
abstract::Neurophysiological and neuroimaging data suggest that the brains of not only children but also adults are reorganized based on sensory inputs and behaviors. Plastic changes in the brain are generally beneficial; however, maladaptive cortical reorganization in the auditory cortex may lead to hearing disorders such as t...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2018/2546250
更新日期:2018-05-20 00:00:00
abstract::Proper density and morphology of dendritic spines are important for higher brain functions such as learning and memory. However, our knowledge about molecular mechanisms that regulate thedevelopment and maintenance of dendritic spines is limited. We recently reported that cyclin-dependent kinase 5 (Cdk5) is required f...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/6790743
更新日期:2016-01-01 00:00:00
abstract::The formation of the complex cerebellar cortical circuits follows different phases, with initial synaptogenesis and subsequent processes of refinement guided by a variety of mechanisms. The regularity of the cellular and synaptic organization of the cerebellar cortex allowed detailed studies of the structural plastici...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/6595740
更新日期:2017-01-01 00:00:00
abstract::Despite the fact that astrocytes are the most abundant glial cells, critical for brain function, few studies have dealt with their possible role in neurodegenerative diseases like Parkinson's disease (PD). This article explores relevant evidence on the involvement of astrocytes in experimental PD neurodegeneration fro...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2020/1859431
更新日期:2020-02-07 00:00:00
abstract::Success in locomotor rehabilitation programs can be improved with the use of brain-computer interfaces (BCIs). Although a wealth of research has demonstrated that locomotion is largely controlled by spinal mechanisms, the brain is of utmost importance in monitoring locomotor patterns and therefore contains information...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2012/375148
更新日期:2012-01-01 00:00:00
abstract:Background:One in three survivors of stroke experience poststroke depression (PSD). PSD has been linked with poorer recovery of function and cognition, yet our understanding of potential mechanisms is currently limited. Alterations in resting-state functional MRI have been investigated to a limited extent. Fluctuations...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/2357107
更新日期:2019-07-28 00:00:00
abstract::The objective of this study was to assess the evolution of diffusion-weighted imaging (DWI) and diffusion-tensor imaging (DTI) over the first month of life in asphyxiated newborns treated with hypothermia and to compare it with that of healthy newborns. Asphyxiated newborns treated with hypothermia were enrolled prosp...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2015/653727
更新日期:2015-01-01 00:00:00
abstract::The concept of a topographical map of the corpus callosum (CC) has emerged from human lesion studies and from electrophysiological and anatomical tracing investigations in other mammals. Over the last few years a rising number of researchers have been reporting functional magnetic resonance imaging (fMRI) activation i...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2013/251308
更新日期:2013-01-01 00:00:00
abstract::Synaptopathies are diseases with synapse defects as shared pathogenic features, encompassing neurodegenerative disorders such as Parkinson's disease (PD). In sporadic PD, the most common age-related neurodegenerative movement disorder, nigrostriatal dopaminergic deficits are responsible for the onset of motor symptoms...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2017/5012129
更新日期:2017-01-01 00:00:00
abstract::High-frequency synchronization has been found in many real neural systems and is confirmed by excitatory/inhibitory (E/I) network models. However, the functional role played by it remains elusive. In this paper, it is found that high-frequency synchronization in E/I neuronal networks could improve the firing rate cont...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8823111
更新日期:2020-11-09 00:00:00
abstract::The current study is aimed at establishing links between brain network examination and neural plasticity studies measured by optical neuroimaging. Sixteen healthy subjects were recruited from the University of Macau to test the Granger Prediction Estimation (GPE) method to investigate brain network connectivity during...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8882207
更新日期:2020-10-06 00:00:00
abstract::With action video games (AVGs) becoming increasingly popular worldwide, the cognitive benefits of AVG experience have attracted continuous research attention over the past two decades. Research has repeatedly shown that AVG experience can causally enhance cognitive ability and is related to neural plasticity in gray m...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/7543686
更新日期:2017-01-01 00:00:00
abstract::Evidence suggests that inflammation and neurogenesis play an important role in major depressive disorder (MDD). Mahuang-Fuzi-Xixin decoction (MFX), as the traditional Chinese prescription, has been widely applied for asthma, migraine, and MDD in clinics. However, the effects of MFX on the potential mechanism in MDD ar...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2019/1571392
更新日期:2019-11-11 00:00:00
abstract::Several studies have associated reduced expression of synaptosomal-associated protein of 25 kDa (SNAP-25) with schizophrenia, yet little is known about its role in the illness. In this paper, a forebrain glutamatergic neuron-specific SNAP-25 knockout mouse model was constructed and studied to explore the possible path...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2017/4526417
更新日期:2017-01-01 00:00:00
abstract:Background:Surround inhibition is a system that sharpens sensation by creating an inhibitory zone around the central core of activation. In the motor system, this mechanism probably contributes to the selection of voluntary movements, and it seems to be lost in dystonia. Objectives. To explore if sensory information is...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2018/4135708
更新日期:2018-10-10 00:00:00
abstract::Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve histamine receptor-mediated ...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2007/91236
更新日期:2007-01-01 00:00:00
abstract::The role of cerebellar plasticity has been increasingly recognized in learning. The privileged relationship between the cerebellum and the inferior olive offers an ideal circuit for attempting to integrate the numerous evidences of neuronal plasticity into a translational perspective. The high learning capacity of the...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2013/853654
更新日期:2013-01-01 00:00:00
abstract::Fragile X syndrome (FXS) is an inheritable neuropsychological disease caused by expansion of the CGG trinucleotide repeat affecting the fmr1 gene on X chromosome, resulting in silence of the fmr1 gene and failed expression of FMRP. Patients with FXS suffer from cognitive impairment, sensory integration deficits, learn...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/2016/9353929
更新日期:2016-01-01 00:00:00
abstract::Histamine H4 receptor has been confirmed to play a role in evoking peripheral pruritus. However, the ionic and intracellular signaling mechanism of activation of H4 receptor on the dorsal root ganglion (DRG) neurons is still unknown. By using cell culture and calcium imaging, we studied the underlying mechanism of act...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2016/1682972
更新日期:2016-01-01 00:00:00
abstract::The recent developments of a particular approach to analyzing motor synergies based on the principle of motor abundance has allowed a quantitative assessment of multi-effector coordination in motor tasks involving anticipatory adjustments to self-triggered postural perturbations and in voluntary postural sway. This ap...
journal_title:Neural plasticity
pub_type: 杂志文章,评审
doi:10.1155/NP.2005.119
更新日期:2005-01-01 00:00:00
abstract::Ample evidence suggests that estrogens have strong influences on the occurrence of stress-related mood disorders, but the underlying mechanisms remain poorly understood. Through multiple approaches, we demonstrate that the G protein-coupled estrogen receptor (GPER) is widely distributed along the HPA axis and in brain...
journal_title:Neural plasticity
pub_type: 杂志文章
doi:10.1155/2020/8866187
更新日期:2020-08-28 00:00:00