Abstract：
:The ovarian cancer biomarker CA125 has been extensively investigated over the last 30 years. The knowledge about the exact molecular nature of this protein, however, remains fragmented. This review provides an overview of the structural research regarding CA125, and presents an orthogonal verification method to confirm the identity of this molecule. The need for independent identification of CA125 is exemplified by several reports where mutually exclusive data concerning the existence of isoforms and the glycan moieties is presented. Mass spectrometry can overcome the pitfalls of a single detection/identification method such as antibody probing. Independent verification of CA125 identity in characterization studies will help establish a refined model of its molecular structure that will promote the development of new approaches for diagnosis, prognosis and therapy of ovarian cancer.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Weiland F,Martin K,Oehler MK,Hoffmann Pdoi
10.3390/ijms130810568subject
Has Abstractpub_date
2012-01-01 00:00:00pages
10568-82issue
8issn
1422-0067pii
ijms-13-10568journal_volume
13pub_type
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