Abstract:
BACKGROUND:KHU14, an ethanolic extract of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) was tested for its anti-inflammatory effects. METHODS:Three out of 20 herbs were found to have anti-inflammatory effects. The formulation of these herbs, i.e. KHU14 was tested for croton oil-induced ear edema, carrageenan-induced paw edema, acetic acid-induced capillary permeability, cotton pellet and delayed type hypersensitivity. RESULTS:KHU14 exhibited anti-inflammatory effects in animal models of acute and chronic inflammation. The anti-inflammatory activity of KHU14 observed was comparable to that of celecoxib. KHU14 inhibited the production of NO and PGE2 in LPS/IFN-gamma-stimulated peritoneal macrophages, and reduced edema and the amount of infiltrated cells in animal models. CONCLUSION:KHU14 exhibited anti-inflammatory effects as demonstrated in typical immunological tests for anti-inflammation in vitro and in vivo.
journal_name
Chin Medjournal_title
Chinese medicineauthors
Kim KS,Rhee HI,Park EK,Jung K,Jeon HJ,Kim JH,Yoo H,Han CK,Cho YB,Ryu CJ,Yang HI,Yoo MCdoi
10.1186/1749-8546-3-10subject
Has Abstractpub_date
2008-09-02 00:00:00pages
10issn
1749-8546pii
1749-8546-3-10journal_volume
3pub_type
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