Abstract:
BACKGROUND:Radix Salvia miltiorrhiza (Danshen) has been used as a principal herb in treating cardiovascular diseases in Chinese medicine. Salvianolic acid B (SA-B), a water-soluble active component of Danshen, was found to have anti-myocardial ischemia (anti-MI) effect. This study aims to investigate mechanisms of SA-B on MI. METHODS:Five conventional Western medicines (isosorbide dinitrate, verapamil, propranolol, captopril and trimethazine) with different mechanisms for treating cardiovascular diseases were selected as positive references to compare with SA-B in changing of the metabolomic profiles in MI rats under treatment. Potential mechanisms of SA-B were further investigated in H9C2 cell line. RESULTS:The metabolomic profiles between SA-B- and propranolol-treated MI rats were similar, since there was a big overlap between the two groups in the PLS-DA score plot. Finally, it was demonstrated that SA-B exhibited a protective effect on MI mainly by decreasing the concentration of cyclic adenosine monophosphate (cAMP) and Ca2+ and inhibiting protein kinase A (PKA). CONCLUSION:SA-B and propanolol exhibited similar metabolomic profiles, indicating that the two drugs might have a similar mechanism.
journal_name
Chin Medjournal_title
Chinese medicineauthors
Lu Y,Zheng Y,Liu X,Liang X,Ngai S,Li T,Zhang Wdoi
10.1186/1749-8546-7-6subject
Has Abstractpub_date
2012-03-13 00:00:00pages
6issue
1issn
1749-8546pii
1749-8546-7-6journal_volume
7pub_type
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