The drug likeness analysis of anti-inflammatory clerodane diterpenoids.

Abstract:

:Inflammation is an active defense response of the body against external stimuli. Long term low-grade inflammation has been considered as a deteriorated factor for aging, cancer, neurodegeneration and metabolic disorders. The clinically used glucocorticoids and non-steroidal anti-inflammatory drugs are not suitable for chronic inflammation. Therefore, it's urgent to discover and develop new effective and safe drugs to attenuate inflammation. Clerodane diterpenoids, a class of bicyclic diterpenoids, are widely distributed in plants of the Labiatae, Euphorbiaceae and Verbenaceae families, as well as fungi, bacteria, and marine sponges. Dozens of anti-inflammatory clerodane diterpenoids have been identified on different assays, both in vitro and in vivo. In the current review, the up-to-date research progresses of anti-inflammatory clerodane diterpenoids were summarized, and their druglikeness was analyzed, which provided the possibility for further development of anti-inflammatory drugs.

journal_name

Chin Med

journal_title

Chinese medicine

authors

Feng Z,Cao J,Zhang Q,Lin L

doi

10.1186/s13020-020-00407-w

subject

Has Abstract

pub_date

2020-12-09 00:00:00

pages

126

issue

1

issn

1749-8546

pii

10.1186/s13020-020-00407-w

journal_volume

15

pub_type

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