Abstract:
BACKGROUND:Herba Cistanches (Roucongrong) is effective in treating Shenxu Zheng ('kidney-deficiency syndrome'). However, the mechanisms and systemic metabolic responses to the herbal intervention are unclear. METHODS:Using GC-MS-based metabolic profiling, we investigated the metabolic responses to Herba Cistanches intervention in a rat model of the hydrocortisone-induced 'kidney-deficiency syndrome'. RESULTS:The metabolic profiles of the rats after hydrocortisone injection deviated from the pre-dose metabolic state at different time points, ranging from day 1 to day 10, whereas the metabolic profiles of the rats treated with both hydrocortisone and water extract of Herba Cistanches returned to the pre-dose state on day 10. CONCLUSION:The intervention of Herba Cistanches caused a systemic recovery from the hydrocortisone-induced metabolic perturbation in rats. This study also demonstrates that metabolic profiling is useful in studying therapeutic mechanisms of herbal medicines.
journal_name
Chin Medjournal_title
Chinese medicineauthors
Qiu Y,Chen M,Su M,Xie G,Li X,Zhou M,Zhao A,Jiang J,Jia Wdoi
10.1186/1749-8546-3-3subject
Has Abstractpub_date
2008-03-10 00:00:00pages
3issn
1749-8546pii
1749-8546-3-3journal_volume
3pub_type
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