Ocular graft-versus-host disease.

Abstract:

PURPOSE OF REVIEW:This review was carried out to study the frequency, and severity of ocular surface involvement at the setting of allogeneic hematopoietic stem cell transplantation and subsequent graft-versus-host disease (GVHD) and evaluate the clinical outcomes of newer treatments. RECENT FINDINGS:Ocular involvement has been reported in 60-90% of patients with chronic GVHD. Although dry eye is the most frequent finding occurring in the great majority of patients (up to 90%), posterior segment complications are also not infrequent, seen in 12.8% of patients after bone marrow transplantation. Anti-inflammatory treatments particularly T-cell suppressants seem to have a beneficial effect in managing GVHD. Corticoteroids, calcineurin inhibitors, such as cyclosporine and tacrolimus, as well as antifibrotic agents such as tranilast are available options for topical application. Cyclosporine ophthalmic drop seems to be a well tolerated and effective treatment modality; favorable results have been demonstrated with increased dosage. SUMMARY:GVHD is an increasingly frequent cause of ocular surface morbidity with the potential of visual loss from corneal involvement. Early diagnosis and aggressive local as well as systemic treatment can be vision saving.

authors

Hessen M,Akpek EK

doi

10.1097/ACI.0b013e328357b4b9

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

540-7

issue

5

eissn

1528-4050

issn

1473-6322

journal_volume

12

pub_type

杂志文章,评审
  • Oral mite anaphylaxis: who, when, and how?

    abstract:PURPOSE OF REVIEW:To present an update on the recent advances in the understanding of the mechanisms and practical management of oral mite anaphylaxis (OMA, pancake syndrome). RECENT FINDINGS:Among novel observations regarding OMA, this review highlights the increased prevalence of aspirin/NSAID hypersensitivity inpat...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章

    doi:10.1097/ACI.0000000000000624

    authors: Sánchez-Borges M,Capriles-Hulett A,Fernandez-Caldas E

    更新日期:2020-06-01 00:00:00

  • Ant allergy in Asia and Australia.

    abstract:PURPOSE OF REVIEW:Anaphylaxis due to ant sting is increasingly being recognized as a significant problem. Severe allergic reactions to ants are well described in the south-eastern United States, but have only been recognized in recent years as being important in other parts of the world. There are many different ant sp...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/01.all.0000136761.51195.01

    authors: Shek LP,Ngiam NS,Lee BW

    更新日期:2004-08-01 00:00:00

  • Animal models of anaphylaxis.

    abstract:PURPOSE OF REVIEW:In this review we will focus on recent advances in the role of mast cells in the pathophysiology of insect allergy and the possible mechanisms of mast cell activation in anaphylaxis. RECENT FINDINGS:Anaphylactic reactions in the mouse can be induced by several independent pathways involving immunoglo...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0b013e32825ea543

    authors: Nauta A,Knippels L,Garssen J,Redegeld F

    更新日期:2007-08-01 00:00:00

  • Food allergy and atopic eczema.

    abstract:PURPOSE OF REVIEW:To review recent developments on the inter-relationship between food allergy and atopic eczema, with a particular focus on understanding the role of filaggrin gene defects. RECENT FINDINGS:Filaggrin gene defects have recently been identified as a major risk factor for the development of atopic eczema...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0b013e3283387fae

    authors: Worth A,Sheikh A

    更新日期:2010-06-01 00:00:00

  • Angioedema associated with nonsteroidal anti-inflammatory drugs.

    abstract:PURPOSE OF REVIEW:The review critically assesses the different phenotypes of angioedemas associated with NSAIDs. Angioedemas exacerbated or induced by NSAIDs have high morbidity and, when they affect the larynx, can lead to death by asphyxiation. RECENT FINDINGS:Angioedema can present as a manifestation of a syndrome ...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0000000000000292

    authors: Giavina-Bianchi P,Aun MV,Jares EJ,Kalil J

    更新日期:2016-08-01 00:00:00

  • Contributions of innate lymphocytes to allergic responses.

    abstract:PURPOSE OF REVIEW:Allergic diseases represent a growing global health concern, especially among pediatric populations. Current strategies for the treatment of allergies and asthma focus on limiting the severity of the symptoms; however, additional research investigating the mechanisms promoting inflammation in the cont...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0000000000000515

    authors: Inclan-Rico JM,Ponessa JJ,Siracusa MC

    更新日期:2019-04-01 00:00:00

  • The ethical framing of personalized medicine.

    abstract:PURPOSE OF REVIEW:Personalized medicine encompasses the use of biological information such as genomics to provide tailored interventions for patients. The review explores the ethical, legal, and social issues that have emerged with personalized medicine and must be considered because of the complex nature of providing ...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0000000000000091

    authors: Joly Y,Saulnier KM,Osien G,Knoppers BM

    更新日期:2014-10-01 00:00:00

  • Stinging ants.

    abstract::Ants belong to the order Hymenoptera, along with bees, wasps, yellow jackets, etc., they are the most successful animal genera in this world. It is their selfless social structure which accounts for their huge impact. Their effect on man ranges from the parasol ant, which makes plant cultivation untenable in certain p...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/01.all.0000011036.74215.95

    authors: Rhoades R

    更新日期:2001-08-01 00:00:00

  • Ocular allergic contact dermatitis from topical drugs.

    abstract:PURPOSE OF REVIEW:Ocular allergic contact dermatitis is a common yet challenging and frequently misdiagnosed condition. Inappropriate or delayed treatment can contribute to a variety of clinical symptoms such as tearing and itching with signs such as ptosis and cicatricial ectropion, resulting in deterioration of disea...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章

    doi:10.1097/ACI.0000000000000677

    authors: Erdinest N,Nche E,London N,Solomon A

    更新日期:2020-10-01 00:00:00

  • The genes and the environment in nasal allergy.

    abstract:PURPOSE OF REVIEW:In this review, we summarize the latest publications on the genetic and environmental determinants of allergic rhinitis. RECENT FINDINGS:Recent advances in genetic technology and bioinformatics have enabled simultaneous unbiased analysis of the entire genome regarding DNA sequence variants, epigeneti...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0000000000000207

    authors: Chiarella SE,Fernandez R,Avila PC

    更新日期:2015-10-01 00:00:00

  • Updates on the use of inhaled corticosteroids in asthma.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to compare and contrast the newer inhaled corticosteroid (ICS) ciclesonide with older ICSs in terms of pharmacodynamic and pharmacokinetic properties and how these affect comparative efficacy. In addition, clinical dosing strategies for ICSs including as-needed use will b...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0b013e328348a813

    authors: Stoloff SW,Kelly HW

    更新日期:2011-08-01 00:00:00

  • Immunology of chronic beryllium disease.

    abstract:PURPOSE OF REVIEW:This review discusses the immunology of chronic beryllium disease. It addresses the importance of the interaction between class II molecules and the T cells that recognize beryllium, along with the subsequent immune response that results in sensitization and disease, and genetic factors leading to var...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0b013e3282f824a4

    authors: Samuel G,Maier LA

    更新日期:2008-04-01 00:00:00

  • Ocular allergy.

    abstract:PURPOSE OF REVIEW:Ocular allergy is often encountered by allergists, ophthalmologists, pediatricians, and primary care physicians. An understanding of the immunologic mechanisms, the differential diagnosis, the clinical features, and the treatment of ocular allergy will be useful to all physicians who encounter these p...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0b013e32834a9652

    authors: Friedlaender MH

    更新日期:2011-10-01 00:00:00

  • Mammalian milk allergy: clinical suspicion, cross-reactivities and diagnosis.

    abstract:PURPOSE OF REVIEW:Cow's milk allergy affects 2-3% of young children, the economic impact of which necessitates search for simple diagnostic tools and affordable milk substitutes. This review examines recent studies on the diagnosis of cow's milk allergy as well as on the allergenicity of milk from other mammalian speci...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章

    doi:10.1097/ACI.0b013e32832b3f33

    authors: Järvinen KM,Chatchatee P

    更新日期:2009-06-01 00:00:00

  • An overview on safety of monoclonal antibodies.

    abstract:PURPOSE OF REVIEW:Biological agents have been a treatment option for many chronic immune-mediated diseases as well as oncological conditions. The issue of infusion reactions is of particular importance and at least in some cases related to the immunogenicity of these drugs with the production of antidrug antibodies. In...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0000000000000315

    authors: Matucci A,Nencini F,Pratesi S,Maggi E,Vultaggio A

    更新日期:2016-12-01 00:00:00

  • Hypersensitivity reactions to quinolones.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to examine in detail the new advances in the pathomechanisms and diagnosis of immediate and nonimmediate hypersensitivity reactions to quinolones, as well as analyze cross-reactivity among different quinolones. RECENT FINDINGS:Hypersensitivity reactions to quinolones, es...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0b013e3283489bc3

    authors: Blanca-López N,Andreu I,Torres Jaén MJ

    更新日期:2011-08-01 00:00:00

  • Asthma in inner city children: recent insights: United States.

    abstract:PURPOSE OF REVIEW:Children living in US inner cities experience disparate burdens of asthma, especially in severity, impairment, exacerbations, and morbidity. Investigations seeking to better understand the factors and mechanisms underlying asthma prevalence, severity, and exacerbation in children living in these commu...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0000000000000423

    authors: Dutmer CM,Kim H,Searing DA,Zoratti EM,Liu AH

    更新日期:2018-04-01 00:00:00

  • Anaphylaxis in adolescents.

    abstract:PURPOSE OF REVIEW:The frequency of hospitalization for anaphylaxis has increased over the last 20 years across Europe, Australia, and North America, particularly, for food and medication triggers. Adolescents show the highest risk for morbidity and fatality from food-induced anaphylaxis, yet there is little high-qualit...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0000000000000572

    authors: Comberiati P,Spahn J,Peroni DG

    更新日期:2019-10-01 00:00:00

  • Allergen-immunostimulatory oligodeoxynucleotide conjugate: a novel allergoid for immunotherapy.

    abstract:PURPOSE OF REVIEW:To summarize the data of both preclinical studies and initial clinical trials of a novel allergoid for allergen specific immunotherapy. This allergoid consists of allergen covalently coupled to immunostimulatory oligodeoxynucleotide DNA sequences. RECENT FINDINGS:Recently, immunostimulatory oligodeox...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/00130832-200212000-00012

    authors: Spiegelberg HL,Horner AA,Takabayashi K,Raz E

    更新日期:2002-12-01 00:00:00

  • The impact of stress on the development and expression of atopy.

    abstract:PURPOSE OF REVIEW:Biological hypersensitivity to environmental stimuli is a fundamental feature of atopy predisposing to a number of clinically expressed disorders including allergic rhinitis, atopic dermatitis or eczema, and allergic asthma. There is provocative evidence that psychological stress constitutes an increa...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/00130832-200502000-00006

    authors: Wright RJ,Cohen RT,Cohen S

    更新日期:2005-02-01 00:00:00

  • What makes a chemical a respiratory sensitizer?

    abstract:PURPOSE OF REVIEW:In this article we consider the characteristics that are associated with chemical respiratory allergens, and that may be essential for effective sensitization of the respiratory tract. RECENT FINDINGS:Chemical respiratory allergens share some characteristics with other chemical allergens, specificall...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/01.all.0000162302.82233.93

    authors: Kimber I,Dearman RJ

    更新日期:2005-04-01 00:00:00

  • Can knowledge of the molecular structure of allergens improve immunotherapy?

    abstract::Conventional immunotherapy may be associated with the development of adverse reactions, including anaphylaxis, due to the use of increasing doses of allergen. Standardization of extracts is necessary in order to assess the correct amount of allergen administered. In recent years, increased knowledge on the molecular s...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/00130832-200112000-00010

    authors: Pomés A,Chapman MD

    更新日期:2001-12-01 00:00:00

  • The voice of the patients: allergic rhinitis is not a trivial disease.

    abstract:PURPOSE OF REVIEW:Patient and physician perspectives on the impact of allergic rhinitis have previously been studied in the general population. We evaluated the burden of allergic rhinitis among patients from the members of European allergy patient organizations. The Patient Voice Allergy Survey was a quantitative, sel...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0b013e3282f3f42f

    authors: Valovirta E,Myrseth SE,Palkonen S

    更新日期:2008-02-01 00:00:00

  • Tryptase values in anaphylaxis and insect allergy.

    abstract:PURPOSE OF REVIEW:To recognize the relevance of serum tryptase measurement as a useful tool for the diagnosis of allergic diseases and mast cell disorders. RECENT FINDINGS:Recent data on the role of mast cells and tryptase in allergic and other diseases provide new understanding into the mechanisms and causes of anaph...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0000000000000569

    authors: Bonadonna P,Scaffidi L,Boni E

    更新日期:2019-10-01 00:00:00

  • Allergen uptake and presentation by dendritic cells.

    abstract::Allergic diseases such as atopic dermatitis, rhinitis and asthma are thought to result from a dysregulated immune response to commonly encountered antigens in genetically predisposed individuals. This response leads to chronic eosinophil-rich allergic inflammation and is controlled by Th2 lymphocytes. The first step i...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/01.all.0000010985.57414.74

    authors: Lambrecht BN

    更新日期:2001-02-01 00:00:00

  • Neutrophil activation in occupational asthma.

    abstract:PURPOSE OF REVIEW:The aim of this review is to emphasize the role of neutrophils in patients with occupational asthma. This review facilitates a better understanding, accurate diagnosis, and proper management of asthmatic reactions provoked at the workplace. RECENT FINDINGS:Increased recruitment and infiltration of ne...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0000000000000507

    authors: Choi Y,Lee Y,Park HS

    更新日期:2019-04-01 00:00:00

  • Genetically engineered negative signaling molecules in the immunomodulation of allergic diseases.

    abstract:PURPOSE OF REVIEW:This review summarizes current knowledge regarding the control of human mast cell and basophil signaling and recent developments using a new therapeutic platform consisting of a human bifunctional gamma and epsilon heavy chain (Fc gamma-Fc epsilon) protein to inhibit allergic reactivity. RECENT FINDI...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/00130832-200412000-00015

    authors: Saxon A,Zhu D,Zhang K,Allen LC,Kepley CL

    更新日期:2004-12-01 00:00:00

  • Asthma/obstructive pulmonary disease overlap: update on definition, biomarkers, and therapeutics.

    abstract:PURPOSE OF REVIEW:Asthma/chronic obstructive pulmonary disease overlap (ACO) continues to be a poorly understood condition. This review discusses newly proposed criteria and potential biomarkers in ACO, to aid in diagnosis and research studies, and prudent therapeutic approaches. RECENT FINDINGS:A global expert panel ...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章

    doi:10.1097/ACI.0000000000000596

    authors: Generoso A,Oppenheimer J

    更新日期:2020-02-01 00:00:00

  • Inner-city asthma: special considerations for management.

    abstract:PURPOSE OF REVIEW:Asthma is prevalent in inner-city populations, exhibiting significant morbidity and mortality. This review focuses on the consequential findings of recent literature, providing insight into onset of asthma, complicating factors, prediction of exacerbations, and novel treatment strategies. RECENT FIND...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0000000000000254

    authors: Dutmer CM,McGraw MD,Liu AH

    更新日期:2016-04-01 00:00:00

  • Genetic and nongenetic factors that may predispose individuals to allergic drug reactions.

    abstract:PURPOSE OF REVIEW:Defining predisposition to allergic drug reactions has largely focussed on HLA associations, but other genetic and nongenetic factors are also likely to be involved. RECENT FINDINGS:Polymorphic genetic variants in cytokine genes, including IL-10, and co-signalling pathways, including CTLA4, have been...

    journal_title:Current opinion in allergy and clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1097/ACI.0000000000000459

    authors: Gibson A,Ogese M,Pirmohamed M

    更新日期:2018-08-01 00:00:00