Abstract：
OBJECTIVE:To evaluate the rate of and potential risk factors for bloodstream infections (BSIs) using data from the REVEAL (Registry to Evaluate Early and Long-term Pulmonary Arterial Hypertension [PAH] Disease Management) REGISTRY(®), which provides current information about patients with PAH. PATIENTS AND METHODS:Patients were enrolled from March 30, 2006, through December 8, 2009, and data on reported BSIs were collected through the third quarter of 2010. Bloodstream infection rates were calculated per 1000 patient-days of risk. RESULTS:Of 3518 patients enrolled, 1146 patients received intravenous (IV) prostanoid therapy for more than 1 day (no BSI, n=1023; ≥1 BSI, n=123; total BSI episodes, n=166). Bloodstream infections rates were significantly increased in patients receiving IV treprostinil vs IV epoprostenol (0.36 vs 0.12 per 1000 treatment days; P<.001), primarily due to gram-negative organisms (0.20 vs 0.03 per 1000 treatment days; P<.001). Multivariate analysis adjusting for age, causes of PAH, and year of BSI found that treatment with IV treprostinil was associated with a 3.08-fold increase (95% confidence interval, 2.05-4.62; P<.001) in BSIs of any type and a 6.86-fold increase (95% confidence interval, 3.60-13.07; P<.001) in gram-negative BSIs compared with treatment with IV epoprostenol. CONCLUSION:Compared with IV epoprostenol therapy, treatment with IV treprostinil is associated with a significantly higher rate of gram-negative BSIs; observed differences in BSI rate did not seem to be due to any other analyzed factors. TRIAL REGISTRATION:clinicaltrials.gov Identifier: NCT00370214.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Kitterman N,Poms A,Miller DP,Lombardi S,Farber HW,Barst RJdoi
10.1016/j.mayocp.2012.05.014subject
Has Abstractpub_date
2012-09-01 00:00:00pages
825-34issue
9eissn
0025-6196issn
1942-5546pii
S0025-6196(12)00630-1journal_volume
87pub_type
杂志文章,多中心研究abstract：:Breast reconstruction immediately after mastectomy is being used with increasing frequency. In a study of the first 100 consecutive patients at our institution who underwent this procedure, with (21 patients) or without (79 patients) later nipple reconstruction, 85% responded affirmatively on a follow-up questionnaire...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)62440-9
更新日期：1987-03-01 00:00:00
abstract：:The two-column procedure for plasma catecholamine determination was adopted as a routine diagnostic test. It was found that the recovery of catecholamine added to properly preserved plasma was 65%. The most efficient recovery occurred when the water content of alumina used was above 23%. Both interassay and intra-assa...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1976-02-01 00:00:00
abstract：OBJECTIVE:To assess the results of laparoscopic splenectomy as a treatment for immune thrombocytopenic purpura (ITP). MATERIAL AND METHODS:We conducted a retrospective study of all patients who underwent laparoscopic splenectomy for ITP at our institution between August 1992 and May 1997. RESULTS:Of 27 patients who u...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/74.1.37
更新日期：1999-01-01 00:00:00
abstract：:Three case reports in this article illustrate the diagnostic methods used and the treatment course encountered for many patients with diabetic peripheral neuropathic pain (DPNP). Each case addresses an aspect of DPNP: pain that appears to be refractory to initial therapy, DPNP occurring with other medical conditions, ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(11)61476-6
更新日期：2006-04-01 00:00:00
abstract：:In this case of Sertoli cell tumor of the testis, no laboratory or clinical evidence of hormonal imbalance was present. The histologic and ultrastructure characteristic of the tumor agreed closely with previous reports on these rare tumors of the gonadal stroma. ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1975-08-01 00:00:00
abstract：:This discussion concerns an overview of our considerations of the adrenergic nervous system with respect to those areas of the nervous system that provide direct sensory input to the brain in control of arterial pressure; those brain centers that also participate in regulating arterial pressure; certain neurohumoral c...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：
更新日期：1977-06-01 00:00:00
abstract：:The aim of this study was to determine whether the characteristics of esophageal symptoms may be of diagnostic utility in distinguishing dysphagia of various causes. Included in the study were a total of 499 patients with three types of dysphagia: 234 with dysphagia related to an obstructive lesion in the esophagus, 1...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)62266-6
更新日期：1993-10-01 00:00:00
abstract：:In a retrospective analysis, 63 participants in a cardiac rehabilitation-preventive cardiology program were identified as having low blood concentrations (mean, 34 mg/dl) of high-density lipoprotein cholesterol (HDL-C) and a mean total cholesterol level of 223 mg/dl after 3 months of hygienic measures (aerobic exercis...
journal_title：Mayo Clinic proceedings
pub_type： 临床试验,杂志文章
doi：10.1016/s0025-6196(12)60824-6
更新日期：1992-09-01 00:00:00
abstract：OBJECTIVE:To determine the clinical characteristics of hospitalized patients who died of pulmonary embolism, confirmed by evaluative autopsy. DESIGN:We retrospectively analyzed a series of autopsy cases of pulmonary embolism at a tertiary-care center for the period Jan. 1, 1985, through Dec. 31, 1989. MATERIAL AND ME...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/70.5.417
更新日期：1995-05-01 00:00:00
abstract：:In recent cases on the constitutionality of sentencing to death criminals who were younger than 18 years of age at the time of their crimes or who are mentally retarded, the US Supreme Court has rejected medical evidence that such persons categorically possess diminished culpability. Rather, the Court has accepted the...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)60023-8
更新日期：1993-01-01 00:00:00
abstract：OBJECTIVE:To report the clinicopathologic findings in patients with Grover's disease. MATERIAL AND METHODS:We reviewed the medical records and biopsy specimens from 72 patients with transient acantholytic dermatosis (Grover's disease) examined at Mayo Clinic Rochester. Hematoxylin-eosin-stained biopsy specimens (from ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/74.3.229
更新日期：1999-03-01 00:00:00
abstract：OBJECTIVE:To assess the reliability, durability, and safety of primary and revision total hip arthroplasty (THA) in patients 90 years of age and older. PATIENTS AND METHODS:Between 1970 and 1997, 66 THAs, 48 primary and 18 revision, were done for 65 patients aged 90 to 104 years (mean, 92 years). The Harris hip score ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/78.3.285
更新日期：2003-03-01 00:00:00
abstract：:Considerable morbidity and mortality are associated with infections of vascular prosthetic grafts. Most vascular surgeons believe that once vascular prosthetic graft infections occur, any form of therapy short of removal of the prosthesis will fail. Although recent reports have noted the successful conservative treatm...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1983-07-01 00:00:00
abstract：:Iatrogenic injury-injury caused unintentionally by medical treatment-breaks the oldest and most famous rule of medical ethics: primum non nocere, or above all, do no harm. Medical malpractice law, however, focuses on whether an injury was caused by negligence, not on whether an injury was iatrogenic. Iatrogenic injury...
journal_title：Mayo Clinic proceedings
pub_type： 传,历史文章,杂志文章,评审
doi：10.1016/j.mayocp.2014.05.004
更新日期：2014-09-01 00:00:00
abstract：:Autonomic failure and proximal skeletal myopathy are rare features of the Sjögren syndrome (SS). We describe a 51-year-old woman with primary SS who had development of esophageal dysmotility, urinary retention, severe orthostatism, and skeletal myopathy during a 3-month period after the diagnosis of SS. Her symptoms a...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/74.7.695
更新日期：1999-07-01 00:00:00
abstract：:A 37-year-old man was referred to our institution for assessment of possible sarcoidosis with involvement of the central nervous system. Before referral, he experienced a systemic illness that persisted for several months, during which time ocular and pulmonary noncaseating granulomas were identified. Sarcoidosis with...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)60277-8
更新日期：1992-01-01 00:00:00
abstract：:The neurologist has become increasingly involved in the multidisciplinary treatment of patients with chronic noncancer pain (CNP). Chronic noncancer pain affects a diverse patient population with multiple underlying diagnoses and associated therapies. Following the model of the American Board of Anesthesiology and the...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/78.1.80
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVES:To determine the prevalence of intra- and extra-articular sacroiliac joint (SIJ) pain, which injection is more beneficial, and whether fluoroscopy improves outcomes. PATIENTS AND METHODS:This patient- and evaluator-blinded comparative effectiveness study randomized 125 participants with SIJ pain from April ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.mayocp.2018.08.038
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:To examine 45-year trends in time use and physical activity energy expenditure (PAEE) in a nationally representative sample of US mothers. PARTICIPANTS AND METHODS:We quantified time allocation to physical activity (PA), sedentary behaviors (SED), and PAEE from 1965 to 2010 in mothers with older children (MO...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2013.09.009
更新日期：2013-12-01 00:00:00
abstract：:Understanding the sequence of events responsible for pressure-related natriuresis and their pathophysiologic alterations may be useful in distinguishing various types of essential hypertension of renal origin. The perturbation of a distal step in the sequence is likely to be reflected in a simple physiologic defect. F...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/s0025-6196(12)65384-1
更新日期：1989-11-01 00:00:00
abstract：:In a patient with Wolff-Parkinson-White syndrome, protracted, disabling tachycardia occurred because of low left lateral accessory pathway refractoriness and rapid retrograde conduction, most likely by a septal pathway. Conventional medications, including intravenously administered lidocaine and procainamide, were ine...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1977-09-01 00:00:00
abstract：:An unusual case of a capillary hemangioma of the filum terminale is presented. The successful removal returned the patient to an asymptomatic state. ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1975-03-01 00:00:00
abstract：:Studies were undertaken to determine the effects of lidocaine on ischemic myocardium, which was induced by coronary artery constriction in open-chested dogs. A real-time epicardial fluorescent technique to detect in vivo-reduced nicotinamide adenine dinucleotide (NADH) during 60 seconds of ischemia was used. Blood flo...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
abstract：OBJECTIVE:To evaluate the association of coronary artery calcium (CAC) and coronary heart disease (CHD) events among young and elderly individuals. PARTICIPANTS AND METHODS:This is a secondary analysis of data from a prospective, multiethnic, population-based cohort study designed to study subclinical atherosclerosis....
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,多中心研究
doi：10.1016/j.mayocp.2014.05.017
更新日期：2014-10-01 00:00:00
abstract：:Traditional treatments for men with localized prostate cancer have included both surgical removal and radiation therapy, with their potential adverse effects on patient quality of life. Thus, there has been increasing interest in the development of minimally invasive procedures that use various technologies to deliver...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/79.12.1547
更新日期：2004-12-01 00:00:00
abstract：:Allergen immunotherapy involves exposing a patient to a gradually escalating dose of a specific allergen with the intention of decreasing allergic and inflammatory responses, ultimately leading to a sustained decrease in allergic symptoms. A build-up phase (once weekly injections) is followed by a maintenance phase (o...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/82.9.1119
更新日期：2007-09-01 00:00:00
abstract：:Cephalosporins are broad-spectrum antimicrobial agents that are often used empirically to treat suspected bacterial infections and also to treat culture-proven infections due to selected gram-positive and gram-negative microorganisms. Cephalosporins differ widely in their spectrum of activity, susceptibility to beta-l...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/s0025-6196(12)61731-5
更新日期：1991-10-01 00:00:00
abstract：OBJECTIVE:To evaluate the treatment strategies for primary and secondary management of malignancy-related pericardial effusions. PATIENTS AND METHODS:Retrospective review of Mayo Clinic Rochester charts and external records of patients with pericardial effusion associated with malignant disease who required treatment ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/75.3.248
更新日期：2000-03-01 00:00:00
abstract：:To our knowledge, we describe the first reported case of paradoxical embolization via a patent foramen ovale (PFO) in an adult with moderately severe cystic fibrosis (CF) and advanced lung disease. Fluctuating neurologic symptoms and signs suggestive of cerebrovascular disease in an adult patient with advanced CF may ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/75.10.1100
更新日期：2000-10-01 00:00:00
abstract：:Coronary artery disease (CAD) is the single most common cause of death in the developed world, responsible for about 1 in every 5 deaths. The morbidity, mortality, and socioeconomic importance of this disease make timely accurate diagnosis and cost-effective management of CAD of the utmost importance. This comprehensi...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/mcp.2009.0391
更新日期：2009-12-01 00:00:00
