Abstract：
:Systemic administration of cytotoxic drugs is the primary treatment strategy for patients with advanced cancer. The effect of cytotoxic drugs is to disrupt the DNA of the cells, rendering them unable to replicate and finally killing them; therefore, the fundamental role of a wide range of treatment regimens is typically to induce lethal toxicity in the largest possible number of cancer cells. However, these cytotoxic drugs also damage the normal cells of the host, which limits the dose of the cytotoxic drug. Thus, cancer patients are usually treated at or near the maximum tolerated dose with the implicit intent of eradicating (curing) the tumor after balancing between efficacy in tumor killing and toxicity to the host. With significantly improving patient care, most efforts are focused on the corollary, "The higher the dose, the better." However, the concept that cancer could be considered as a chronic disease and might be treated like other chronic diseases to achieve a status called tumor dormancy is gaining popularity. In addition, there has been increasing interest in putting more effort into administering cytotoxic drugs on a more continuous basis, with a much shorter break period, or none at all, and generally lower doses of various cytotoxic drugs or combinations with other newer, targeted therapies, like anti-angiogenesis agents. This practice has come to be known as metronomic chemotherapy. There is still much to be learned in this field, especially with regard to optimization of the proper drugs, dose, schedule, and tumor type applications. This review will explore recent studies that have addressed the mechanism of metronomic chemotherapy in the management of various tumors, especially gynecologic cancers.
journal_name
Taiwan J Obstet Gynecoljournal_title
Taiwanese journal of obstetrics & gynecologyauthors
Su WH,Ho TY,Li YT,Lu CH,Lee WL,Wang PHdoi
10.1016/j.tjog.2012.04.002subject
Has Abstractpub_date
2012-06-01 00:00:00pages
167-78issue
2eissn
1028-4559issn
1875-6263pii
S1028-4559(12)00058-7journal_volume
51pub_type
杂志文章,评审abstract：OBJECTIVE:The purpose of this methodology study is to examine the relative validity of four dietary assessment methods during pregnancy and to understand the pros and cons of each method. MATERIALS AND METHODS:We recruited 181 healthy pregnant women with less than 20 weeks of gestation and collected information throug...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2014.04.007
更新日期：2014-06-01 00:00:00
abstract：OBJECTIVE:To present prenatal diagnosis and molecular cytogenetic characterization of de novo partial monosomy 1p (1p36.23→pter) and partial trisomy 20p (20p12.1→pter) associated with ventriculomegaly, ventricular septal defect and midface hypoplasia. MATERIALS, METHODS AND RESULTS:A 31-year-old, primigravid woman was...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/S1028-4559(10)60100-3
更新日期：2010-12-01 00:00:00
abstract：OBJECTIVE:This was a retrospective study of the efficacy of urethral overdilation (UOD) for women with voiding dysfunction. MATERIALS AND METHODS:Thirty-six patients diagnosed with voiding dysfunction were enrolled. The main indications for UOD included women with poor compliance (30 patients, 83.3%) and obstructive s...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2014.11.008
更新日期：2015-02-01 00:00:00
abstract：:Abnormal umbilical artery flow with absent or reversed end-diastolic velocity (AREDV) during pregnancy is a strong indication of placental insufficiency. When AREDV occurs prenatally, a close follow-up or expeditious delivery should be contemplated. AREDV in the umbilical artery is associated with intraventricular hem...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1016/S1028-4559(09)60294-1
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVE:To understand the mechanisms of postpartum uterine involution, we investigated the uterine myometrial changes during pregnancy and the postpartum period. MATERIALS AND METHODS:Nine groups of uterine myometrial samples from mice (n = 4) were collected on gestational Day 0 (nonpregnant), Day 1, Day 2, Day 7, D...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2013.01.030
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVE:It is known that most cases of ovarian hyperstimulation syndrome (OHSS) are associated with the therapies for ovulation induction. However, OHSS may rarely be associated with a spontaneous ovulatory cycle, usually in the case of multiple gestations, hypothyroidism or polycystic ovary syndrome. CASE REPORT:A ...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/S1028-4559(09)60241-2
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVE:This study aims to validate the BACs-on-Beads (BoB) technology as a robust and high throughput method for pre-implantation genetic screening (PGS) for aneuploidy. MATERIAL AND METHODS:The performances with respect to the sensitivity, specificity, success rate and detection rate of this technique from new BoB...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2017.01.011
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:To investigate the relationship between placental transthyretin (TTR) level and preeclampsia. MATERIALS AND METHODS:Placental tissues from uncomplicated and preeclamptic pregnancies were analyzed using immunohistochemistry and image analysis. We measured the mean optical density (OD) of immunohistochemical s...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2016.04.014
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:Neonatal candidiasis is a leading infectious cause of significant morbidity and mortality in premature birth mainly due to impaired physical barriers and immature immune system of fetus. Maternal pregnancy-induced hypertension (PIH) has been reported to be able to disturb the neonatal immune system, which cou...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2019.01.017
更新日期：2019-03-01 00:00:00
abstract：OBJECTIVE:We presented a fetus affected by macrocystic lung lesions with progressive hydropic changes during the second trimester, but experienced remarkable resolution of hydrops in the third trimester after a series of in utero interventions. CASE REPORT:A 19-year-old women, G1P0, presented with fetal multilocular t...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2017.04.027
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:Ovarian juvenile granulosa cell tumor has an interesting association with multiple enchondromatosis (Ollier disease and Maffucci syndrome) and should be considered a leading diagnosis when an ovarian mass is found in young patients with these conditions. Besides the association with nonskeletal malignancies, ...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2017.02.002
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:Big submucosal myoma often causes heavy menstrual bleeding and are complicated in hysterscopic surgery. High Intensity Focused Ultrasound (HIFU), is a method for myoma ablation therapy, which may benefit on size reduction, and assist following hysterscopic myomectomy. CASE REPORT:Two cases, case one,. 44-yea...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2019.04.001
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVE:Comparing the safety and effectiveness of the pulsed bipolar (PK) system and conventional electrosurgery in laparoscopic myomectomy (LM). MATERIALS AND METHODS:Retrospective chart review of 194 women with symptomatic uterine fibroids undertaken LM was performed. Cases of LMs with PK cutting forceps were comp...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2009.05.002
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVE:The thalassemias is a group of hereditary disorders with impaired production of functional hemoglobin. In this report we described a rare case of compound heterozygous mutation of South-East Asia type hereditary persistence of fetal hemoglobin (SEA-HPFH) and β -thalassemia that allowed prenatal diagnosis to b...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2018.04.019
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:To investigate the relationship between abnormal degrees of oral glucose tolerance test (OGTT) results and pregnancy outcomes. MATERIALS AND METHODS:A total of 7513 singleton pregnancies screened for gestational diabetes mellitus were enrolled in this retrospective observational study. The pregnancy outcomes...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2013.10.005
更新日期：2013-12-01 00:00:00
abstract：:The beauty of microarray analysis of gene expression (MAGE) is that it can be used to discover some genes that were previously thought to be unrelated to a physiologic or pathologic event. During the period from 1999 to 2007, applications of MAGE in cancer investigation have shifted from molecular profiling, identifyi...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1016/S1028-4559(08)60024-8
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVE:Non-Hodgkins lymphomas (NHL) rarely affect the vagina. As a result, a standard treatment has not been defined. CASE REPORT:A 34-year-old female virgin patient with a primary vaginal NHL stage IEA, diffuse large cell B lineage, showed an excellent response to cytotoxic chemotherapy (cyclophosphamide, doxorubi...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1016/S1028-4559(08)60135-7
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the percentage of pregnant women with negative Group B Streptococcus (GBS) screening results by culture at 35 weeks' gestation, who subsequently had positive GBS test results after 39 weeks' gestation. MATERIALS AND METHODS:From 2006 to 2007, we recruited 150 pregnant wo...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 临床试验,杂志文章
doi：10.1016/S1028-4559(09)60269-2
更新日期：2009-06-01 00:00:00
abstract：:Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Covid-19 pandemic began in the end of 2019 and spread all over the world in a short duration of time. Measures have been taken such as social distancing, compulsory lockdown and restriction of activities so as ...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1016/j.tjog.2020.09.001
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVE:To describe the value of hysteroscopic fetoscopy (virtuopsy) at the time of uterine suction in a case of early diagnosis of congenital anomalies in parents refusing conventional full autopsy examination. CASE REPORT:First trimester ultrasound diagnosis of proboscis, median cleft lip and palate and limb defor...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2015.08.016
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVE:Endometriosis is a chronic inflammatory disease pathologically defined as the presence of endometrial-like tissue outside the uterine cavity. It is one of the most important diseases affecting women of reproductive age. The process of endometriotic implant growth is mediated by many complex interactions of im...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2015.07.004
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVE:We aimed to compare the surgical outcomes between hysterectomy by transvaginal natural orifice transluminal endoscopic surgery (vNOTES) and laparoscopic total hysterectomy (LTH). MATERIALS AND METHODS:This study is a retrospective chart analysis. From January 1, 2015, to December 31, 2017, a total of 183 pat...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2020.05.016
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVE:Many women quit smoking during pregnancy resume in postpartum period and difficult to prevent. No studies had focused on their psychosocial response in Taiwan. We analyzed data from a trial of Taiwan Smoker's Helpline (TSH) to determine factors associated with smoking relapse after delivery. MATERIALS AND ME...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.tjog.2019.07.015
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:Burkitt's lymphoma (BL) occurs mostly in children; bilateral ovarian involvement mimicking a gynecologic malignancy in adults is extremely rare. Here, we report a patient with BL mimicking a gynecologic tumor. CASE REPORT:A 50-year-old Taiwanese woman presented with the complaint of persistent lower abdomina...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/S1028-4559(09)60217-5
更新日期：2006-06-01 00:00:00
abstract：OBJECTIVES:To study the operative outcomes of single-port laparoscopic hysterectomy in uteri greater than 500 g, using either laparoscopic assisted vaginal hysterectomy (LAVH) or laparoscopic supracervical hysterectomy (LSH). MATERIALS AND METHODS:78 patients were included in a single institute by a single surgeon fro...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2020.05.006
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVE:This paper aims to present molecular cytogenetic and epigenetic evaluation of placental mesenchymal dysplasia (PMD). MATERIALS AND METHODS:A 33-year-old woman was referred to the hospital at 18 weeks of gestation because of a multicystic mass in the placenta. Ultrasound showed a normal amount of amniotic flu...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2013.10.036
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVE:Longitudinal data on bone decline in ethnic Chinese elderly are sparse, especially in healthy, aged women. This study reviews the longitudinal change in bone mineral density (BMD) at the femoral neck, great trochanter, and Ward's triangle in healthy elderly Taiwanese women. MATERIALS AND METHODS:A prospectiv...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2012.08.001
更新日期：2013-03-01 00:00:00
abstract：:Menopause occurs naturally when the ovary ceases folliculogenesis, or artificially by surgical and/or medical ablation of the ovarian function. Menopause is a hypoestrogenic state, which may adversely affect estrogen target tissues, such as the brain, skeleton and skin, as well as the cardiovascular and genitourinary ...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1016/S1028-4559(07)60006-0
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVE:Use of vaginal meshes for treatment of pelvic organ prolapse (POP) remains controversial. A trend toward abdominal approaches and the development of new meshes has been noted. We compared the 1-year results of two different approaches using new lightweight meshes. MATERIALS AND METHODS:Sixty-nine (95.8%) of ...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 临床试验,杂志文章
doi：10.1016/j.tjog.2014.07.006
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:Hereditary antithrombin (AT) deficiency increases the risk of venous thromboembolism (VTE) in pregnant woman. We report the first case of administration of recombinant human antithrombin (rhAT) to a pregnant Japanese woman with AT deficiency. CASE REPORT:A 30-year-old woman, gravida 2 para 0, was referred to...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2019.09.021
更新日期：2019-11-01 00:00:00
