Abstract:
:Maturation of the cervix during pregnancy is an essential pre-requisite for an uncomplicated delivery at term. Physiological cervical ripening is characterised by a diffuse loosening of the collagenous connective tissue with widely scattered collagen fibrils and an increased amount of extracellular ground substance. These morphological changes are similar to those after prostaglandin (PG)-pre-treatment of the cervix. The local application of PG leads to a marked mulifocal loosening of the collagen fibre bundles with "activated" fibroblasts, characterised by a fine granular loosening of the cytoplasm, vacuolised enlarged mitochondria and an increased number of cytoplasmatic vesicles close to the cell surface. In the course of pregnancy the volume of the cervix increases by a significant rise in synthesis of collagen, protein, glycosaminoglycan and fibronectin. The change in consistency during late pregnancy corresponds to a significant decrease in dermatan sulphate coninciding with a marked increase in hyaluronic acid concentration associated with increased water uptake. Contrary to the already published literature, enzymatic collagen degradation does not play an important role in physiological cervical maturation. The action of catabolic enzymes (collagenases, glycosidases), liberated from polymorphonuclear leukocytes invading the extracellular matrix, is responsible for the rapid dilatation of the cervix at parturition. This process is limited by the immediate postpartum insudation of the cervix by plasma containing highly potent proteinase inhibitors (e.g. alpha 2-macroglobulin). PG-induced cervical ripening is associated with a time-limited enzymatic collagen degradation, an increased synthesis of non-collagenous proteins and a significant increase in hyaluronic acid concentration. Our basic biochemical findings in cervical ripening and dilatation during parturition may greatly contribute to the development of new concepts in the causal treatment of cervical pathology during pregnancy.
journal_name
Geburtshilfe Frauenheilkdjournal_title
Geburtshilfe und Frauenheilkundeauthors
Rath W,Osmers R,Adelmann-Grill BC,Stuhlsatz HW,Tschesche H,Szevérini Mdoi
10.1055/s-2008-1026341subject
Has Abstractpub_date
1990-09-01 00:00:00pages
657-64issue
9eissn
0016-5751issn
1438-8804journal_volume
50pub_type
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
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journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
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journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 临床试验,杂志文章
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
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journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
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更新日期:1987-04-01 00:00:00
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
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更新日期:1980-10-01 00:00:00
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1977-09-01 00:00:00
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
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更新日期:1981-05-01 00:00:00
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
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更新日期:1976-05-01 00:00:00
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
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更新日期:1986-11-01 00:00:00
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
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更新日期:1983-08-01 00:00:00
abstract::The specific disadvantage of the Vecchietti technique for construction of a vagina in cases of vaginal agenesis is the need for laparotomy. We describe an endoscopically assisted construction of a vagina by a variation of this method and report on the first five cases operated on without any complications and with goo...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
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更新日期:1993-04-01 00:00:00
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/a-1205-0601
更新日期:2020-08-01 00:00:00