Abstract:
BACKGROUND:The assessment of liver damage in various disease states relies on a combination of clinical findings, biochemical parameters and invasive tests such as liver biopsy. The ultrasound elastography has emerged as a potential alternative test, providing quantifiable information on the elasticity/stiffness of the examined-tissues. We assessed the performance of ultrasound elastography using real-time Acoustic Radiation Force Imaging (ARFI) technology in evaluating the degree of liver fibrosis in children with and without liver disease. METHODS:Children aged 0-18 years, hospitalized in the Emergency Clinical County Hospital Tg. Mures, Romania, between September 15, 2010 and January 15, 2011, were eligible for the study. Four groups were recruited as follow: patients with liver disease in the setting of various malignant disorders, children with non-malignant liver disease, overweight and obese children and healthy controls. The liver tissue elasticity was assessed in each individual using Shear Wave Velocity (SWV). Biochemical tests included transaminase levels. 19 children with chronic liver disease underwent biopsies. SWV was measured globally and separately for the liver-segments 1 and 8. Correlations between the SWV and laboratory test were established using non-parametric Spearman correlation test. RESULTS:A total of 103 children underwent liver ultrasound elastographic assessments. Of these, 39 had malignancies, 19 had various chronic liver diseases, 13 had nonalcoholic fatty liver disease (NAFLD), and 32 were healthy controls. The transaminase values differed significantly between children with liver diseases and controls. In normal controls SWV values in the 1st segment were significantly lower compared to those in the in 8th segment of the liver (p=0.0216). In the group with hepatic steatosis, the SWV values were statistically higher compared to those in healthy controls. Positive statistical correlations have been established between AST and SWV in the group of children with NAFLD and those with malignancies (p=0.0032, p=0.0045). CONCLUSIONS:Quantification of liver fibrosis by ARFI method correlates with the histological fibrosis stage in children with chronic liver disease and NAFLD. Clinical applications of this method in the diagnosis of pediatric liver disease deserve further study.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Marginean CO,Marginean Cdoi
10.1016/j.ejrad.2012.04.014subject
Has Abstractpub_date
2012-08-01 00:00:00pages
e870-4issue
8eissn
0720-048Xissn
1872-7727pii
S0720-048X(12)00187-8journal_volume
81pub_type
杂志文章abstract:PURPOSE:This study aimed to evaluate the usefulness of four-dimensional CTA before and after embolization treatment with ONYX-18 in eleven patients with cranial dural arteriovenous fistulas, and to compare the results with those of the reference standard DSA. PATIENTS AND METHODS:Eleven patients with cranial dural art...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2015.03.009
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abstract:AIM:Comparison of the diagnostic value of cinefluoroscopy and simple fluoroscopy in the detection of calcification in coronary arteries. PATIENTS AND METHODS:Data were prospectively obtained from 143 patients in whom simple fluoroscopy as well as cinecoronary arteriography were performed. Excluded were patients with a...
journal_title:European journal of radiology
pub_type: 临床试验,杂志文章
doi:10.1016/0720-048x(94)00597-6
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVES:We aimed to study the ability of contrast enhanced MRI at 1.5 T and 11C-acetate PET/CT, both individually and using fused data, to detect localized prostate cancer. METHODS:Thirty-six men with untreated prostate cancer and negative for metastatic disease on pelvic CT and bone scan were prospectively enrolle...
journal_title:European journal of radiology
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doi:10.1016/j.ejrad.2011.12.043
更新日期:2012-11-01 00:00:00
abstract::A solid dynamic phantom has been constructed, which allows quantitative measurements of the signal-to-noise ratios in processed images from digital subtraction angiography (DSA) units. Profiles of silicone rubber placed in concentric circles on a plate which is rotated in the image plane generates bolus curves with fi...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/0720-048x(90)90104-j
更新日期:1990-07-01 00:00:00
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journal_title:European journal of radiology
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更新日期:1999-04-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ejrad.2011.10.007
更新日期:2012-10-01 00:00:00
abstract:INTRODUCTION:Biopsy of the musculoskeletal system is useful in the management of bone lesions particularly in oncology but they are often challenging procedures with a significant risk of complications. Computed tomography (CT)-guided needle biopsies may decrease these risks but doubts still exist about their diagnosti...
journal_title:European journal of radiology
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journal_title:European journal of radiology
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更新日期:2012-09-01 00:00:00
abstract:PURPOSE:To evaluate the additional value of the color coding of dynamic data using the 3TP method in the evaluation of contrast-enhanced breast MRI for readers with different levels of experience. MATERIALS AND METHODS:A total of 52 lesions were included in this study, 25 malignant and 27 benign. All lesions were eval...
journal_title:European journal of radiology
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
abstract::Teleradiology is probably the most successful eHealth service available today. Its business model is based on the remote transmission of radiological images (e.g. X-ray and CT-images) over electronic networks, and on the interpretation of the transmitted images for diagnostic purpose. Two basic service models are comm...
journal_title:European journal of radiology
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journal_title:European journal of radiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ejrad.2012.01.031
更新日期:2012-05-01 00:00:00
abstract::Minimally invasive therapy has been explored as a potential means of treating breast tumours with minimal disruption to adjacent soft tissues. The purpose of this is to facilitate improved cosmesis and to offer treatment to women who are unfit for surgery. A number of treatment modalities including thermal therapies (...
journal_title:European journal of radiology
pub_type: 杂志文章,评审
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更新日期:2002-04-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章,meta分析,评审
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更新日期:2012-02-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章,评审
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更新日期:2003-08-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/s0720-048x(03)00048-2
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:To assess computed tomography (CT) evaluation of mediastinal nodes in non-small cell lung cancer to predict metastatic involvement by measurement of their axis and surface area in the coronal plane, as compared to standard short-axis measures in the axial plane. METHODS:Evaluation of mediastinal nodes was re...
journal_title:European journal of radiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ejrad.2011.06.015
更新日期:2012-09-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2009.03.024
更新日期:2010-07-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
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journal_title:European journal of radiology
pub_type: 杂志文章
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:
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journal_title:European journal of radiology
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journal_title:European journal of radiology
pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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journal_title:European journal of radiology
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2006.06.008
更新日期:2006-12-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2011.01.108
更新日期:2012-03-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1985-02-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
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更新日期:1998-08-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1986-05-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章,评审
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更新日期:2019-12-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2011.04.004
更新日期:2011-08-01 00:00:00