Abstract：
PURPOSE:We examined whether fluorine-18 fluorodeoxyglucose (FDG) uptake is related to the mammalian target of rapamycin (mTOR) signal pathway and its related proteins in pancreatic cancer patients. METHODS:We retrospectively studied 53 pancreatic cancer patients who underwent FDG positron emission tomography (PET) or FDG PET/CT, and complete curative surgical resection. The SUV max, the tumor to nontumor activity of pancreas [T/N (P)] ratio and the T/N of liver [T/N (L)] ratio were calculated. The expressions of glucose transporter-1(Glut-1) and mTOR pathway proteins in pancreas cell lines were examined by immune blots. Excised tumor tissue was analyzed by immunohistochemistry using monoclonal antibodies for Glut-1, epidermal growth factor receptor (EGFR), mTOR, p70S6kinase (p70S6) and S6 ribosomal protein (S6). RESULTS:The expressions of Glut-1, EGFR and p70S6 were significantly correlated with the SUV max, T/N (P) ratio and T/N (L) ratio. The expressions of mTOR and S6 were not correlated with all parameters. The expression of Glut-1 was positively correlated with the expressions of EGFR and p70S6, but not with mTOR or S6. S6 was positively correlated with p70S6. CONCLUSIONS:Glut-1, EGFR and p70S6 expressions are associated with the FDG uptake mechanism of pancreatic cancer. FDG uptake may predict the levels of EGFR and p70S6 expressions, and FDG uptake reflects glucose metabolism and cancer progression.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Kaida H,Azuma K,Kawahara A,Yasunaga M,Kitasato Y,Hattori S,Taira T,Ureshino H,Kage M,Ishii K,Murakami T,Ishibashi Mdoi
10.1016/j.ejrad.2016.08.007subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1804-1810issue
10eissn
0720-048Xissn
1872-7727pii
S0720-048X(16)30246-7journal_volume
85pub_type
杂志文章abstract：OBJECTIVES:To determine the improvement of emphysema quantification with density correction and to determine the optimal site to use for air density correction on volumetric computed tomography (CT). METHODS:Seventy-eight CT scans of COPD patients (GOLD II-IV, smoking history 39.2±25.3 pack-years) were obtained from s...
journal_title：European journal of radiology
pub_type： 杂志文章
doi：10.1016/j.ejrad.2012.02.021
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abstract：PURPOSE:To evaluate the diagnostic performance of three-dimensional (3D) MR maximum intensity projection (MIP) in the assessment of synovitis of the hand and wrist in rheumatoid arthritis (RA) compared to 3D contrast-enhanced magnetic resonance imaging (CE-MRI). MATERIALS AND METHODS:Twenty-five patients with RA under...
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journal_title：European journal of radiology
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journal_title：European journal of radiology
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journal_title：European journal of radiology
pub_type： 杂志文章,随机对照试验
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更新日期：2012-09-01 00:00:00
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journal_title：European journal of radiology
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journal_title：European journal of radiology
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journal_title：European journal of radiology
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更新日期：2020-03-01 00:00:00
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journal_title：European journal of radiology
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journal_title：European journal of radiology
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