Shear wave elastography versus real-time elastography on evaluation thyroid nodules: a preliminary study.

Abstract:

OBJECTIVE:To comparatively evaluate shear wave elastography (SWE) and real-time elastography (RTE) in distinguishing malignant from benign thyroid nodules. METHODS:49 patients with 64 focal thyroid nodules were enrolled and underwent SWE and RTE before surgery. SWE elasticity indices (mean, minimum and maximum value of 2-mm region of interest) of nodules were measured. For RTE, elastograms were assessed by Rago criteria and nodules with scores of 4 or 5 were classified as suspicious for malignancy. Surgery histopathologic results were adopted as diagnostic standard. RESULTS:Of the 64 nodules, 19 were papillary thyroid carcinomas and 45 were benign. SWE indices were significantly higher in malignant than benign nodules (P<0.05). Areas under the ROC curves (AUC) of SWE parameters were 0.840, 0.831 and 0.788, which were not significantly different from that of RTE showed as 0.880 (P=0.148-0.482). When the most accurate cut-off, 38.3kPa for mean value was applied to predict malignancy, the diagnostic specificity, sensitivity, accuracy, positive predictive value and negative predictive value of SWE and RTE were 68.4% versus 79.0%, 86.7% versus 84.4%, 81.3% versus 78.1%, 68.4% versus 64.7% and 86.7% versus 83.3%, respectively (P=0.683-1.000). CONCLUSION:SWE as a promising tool can be performed in differentiating thyroid nodules with comparable results to RTE.

journal_name

Eur J Radiol

authors

Liu BX,Xie XY,Liang JY,Zheng YL,Huang GL,Zhou LY,Wang Z,Xu M,Lu MD

doi

10.1016/j.ejrad.2014.02.024

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

1135-1143

issue

7

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(14)00118-1

journal_volume

83

pub_type

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