Abstract:
:Piwi-interacting RNAs (piRNAs) and CRISPR RNAs (crRNAs) are two recently discovered classes of small noncoding RNA that are found in animals and prokaryotes, respectively. Both of these novel RNA species function as components of adaptive immune systems that protect their hosts from foreign nucleic acids-piRNAs repress transposable elements in animal germlines, whereas crRNAs protect their bacterial hosts from phage and plasmids. The piRNA and CRISPR systems are nonhomologous but rather have independently evolved into logically similar defense mechanisms based on the specificity of targeting via nucleic acid base complementarity. Here we review what is known about the piRNA and CRISPR systems with a focus on comparing their evolutionary properties. In particular, we highlight the importance of several factors on the pattern of piRNA and CRISPR evolution, including the population genetic environment, the role of alternate defense systems and the mechanisms of acquisition of new piRNAs and CRISPRs.
journal_name
Brief Funct Genomicsjournal_title
Briefings in functional genomicsauthors
Kumar MS,Chen KCdoi
10.1093/bfgp/els016subject
Has Abstractpub_date
2012-07-01 00:00:00pages
277-88issue
4eissn
2041-2649issn
2041-2657pii
els016journal_volume
11pub_type
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journal_title:Briefings in functional genomics
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abstract::Next generation Sequencing (NGS) provides a powerful tool for discovery of domestication genes in crop plants and their wild relatives. The accelerated domestication of new plant species as crops may be facilitated by this knowledge. Re-sequencing of domesticated genotypes can identify regions of low diversity associa...
journal_title:Briefings in functional genomics
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journal_title:Briefings in functional genomics
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journal_title:Briefings in functional genomics
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journal_title:Briefings in functional genomics
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journal_title:Briefings in functional genomics
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journal_title:Briefings in functional genomics
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journal_title:Briefings in functional genomics
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更新日期:2013-05-01 00:00:00
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journal_title:Briefings in functional genomics
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journal_title:Briefings in functional genomics
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更新日期:2020-03-23 00:00:00
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journal_title:Briefings in functional genomics
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journal_title:Briefings in functional genomics
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abstract::The human genome has an almost equal distribution of unique and transposable genetic elements. Although at the transcriptome level, a relatively higher contribution from transposable elements derived RNA has been reported. This is further highlighted with evidence from pervasive transcription. Of the total RNA, noncod...
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更新日期:2021-01-25 00:00:00
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更新日期:2010-07-01 00:00:00
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更新日期:2010-12-01 00:00:00
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journal_title:Briefings in functional genomics
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journal_title:Briefings in functional genomics
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