Abstract:
:Epigenetic memory represents a natural mechanism whereby the identity of a cell is maintained through successive cell cycles, allowing the specification and maintenance of differentiation during development and in adult cells. Cancer is a loss or reversal of the stable differentiated state of adult cells and may be mediated in part by epigenetic changes. The identity of somatic cells can also be reversed experimentally by nuclear reprogramming. Nuclear reprogramming experiments reveal the mechanisms required to activate embryonic gene expression in adult cells and thus provide insight into the reversal of epigenetic memory. In this article, we will introduce epigenetic memory and the mechanisms by which it may operate. We limit our discussion primarily to the context of nuclear reprogramming and briefly discuss the relevance of memory and reprogramming to cancer biology.
journal_name
Brief Funct Genomicsjournal_title
Briefings in functional genomicsauthors
Halley-Stott RP,Gurdon JBdoi
10.1093/bfgp/elt011subject
Has Abstractpub_date
2013-05-01 00:00:00pages
164-73issue
3eissn
2041-2649issn
2041-2657pii
elt011journal_volume
12pub_type
杂志文章,评审abstract::The epitome of any genome research is to identify all the existing genes in a genome and investigate their roles. Various techniques have been applied to unveil the functions either by silencing or over-expressing the genes by targeted expression or random mutagenesis. Rice is the most appropriate model crop for gener...
journal_title:Briefings in functional genomics
pub_type: 杂志文章
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abstract::Since the discovery of RNA splicing in 1977 the knowledge of this important biological process has increased steadily following the identification of many of the mechanistic features of splicing: from the basic cis-acting splicing signals, through the detail composition and dynamics of the spliceosome, to the role pla...
journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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abstract::Aberrant DNA methylation is considered to be one of the most common hallmarks of cancer. Several recent advances in assessing the DNA methylome provide great promise for deciphering the cancer-specific DNA methylation patterns. Herein, we present the current key technologies used to detect high-throughput genome-wide ...
journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/elw010
更新日期:2016-11-01 00:00:00
abstract::Recent data have revealed that the paradigmatic tumour suppressor gene RB1 on chromosome 13 is preferentially expressed from the maternal allele. Imprinted expression of RB1 is linked to a differentially methylated CpG island in intron 2 of this gene (CpG 85). On the paternal chromosome, CpG 85 is unmethylated and act...
journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/elq014
更新日期:2010-07-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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journal_title:Briefings in functional genomics
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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更新日期:2019-02-14 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章
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更新日期:2021-01-25 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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更新日期:2018-09-27 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章
doi:10.1093/bfgp/elx027
更新日期:2018-07-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章
doi:10.1093/bfgp/els037
更新日期:2012-11-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/elv053
更新日期:2017-01-01 00:00:00
abstract::Next generation Sequencing (NGS) provides a powerful tool for discovery of domestication genes in crop plants and their wild relatives. The accelerated domestication of new plant species as crops may be facilitated by this knowledge. Re-sequencing of domesticated genotypes can identify regions of low diversity associa...
journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/elr032
更新日期:2012-01-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/elx038
更新日期:2018-03-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/ely021
更新日期:2018-11-26 00:00:00
abstract::DNA methylation is an epigenetic modification of cytosines that undergoes dynamic changes in a temporal, spatial and cell-type-specific manner. Recent advances in technology have permitted the profiling of high-throughput methylomes in large numbers of biological samples. Various computational tools have been develope...
journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/elw029
更新日期:2016-11-01 00:00:00
abstract::Premature termination of transcription, or attenuation, is an efficient RNA-based regulatory strategy that is commonly used in bacterial organisms. Attenuators are generally located in the 50 untranslated regions of genes or operons and combine a Rho-independent terminator, controlling transcription, with an RNA eleme...
journal_title:Briefings in functional genomics
pub_type: 更正并重新发布的文章,杂志文章,评审
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更新日期:2010-03-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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更新日期:2013-05-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/elu017
更新日期:2015-03-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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更新日期:2016-05-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/elx042
更新日期:2018-11-26 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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更新日期:2013-05-01 00:00:00
abstract::RNA-seq is a methodology for RNA profiling based on next-generation sequencing that enables to measure and compare gene expression patterns at unprecedented resolution. Although the appealing features of this technique have promoted its application to a wide panel of transcriptomics studies, the fast-evolving nature o...
journal_title:Briefings in functional genomics
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更新日期:2015-03-01 00:00:00
abstract::Pluripotent embryonic stem (ES) cells are specialized cells with a dynamic chromatin structure, which is intimately connected with their pluripotency and physiology. In recent years somatic cells have been reprogrammed to a pluripotent state through over-expression of a defined set of transcription factors. These cell...
journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
abstract::Gastric cancer remains the second most common cause of cancer-related death worldwide. Because of the poor prognosis of late-stage gastric cancer patients, it is imperative to develop new strategies to improve the survival rate of this disease. Currently, immunotherapy is considered as an innovative approach for cance...
journal_title:Briefings in functional genomics
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更新日期:2019-03-22 00:00:00
abstract::Genetic variation is crucial for successful barley improvement. Genomic technologies are improving dramatically and are providing access to the genetic diversity within this important crop species. Diverse collections of barley germplasm are being assembled and mined via genome-wide association studies and the identif...
journal_title:Briefings in functional genomics
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journal_title:Briefings in functional genomics
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更新日期:2019-02-14 00:00:00
abstract::Submitting sequences to the National Center for Biotechnology Information (NCBI) is an integral part of research and the publication process for many disciplines within the life sciences, and it will only become more important as sequencing technologies continue to improve. Here, I argue that the available infrastruct...
journal_title:Briefings in functional genomics
pub_type: 杂志文章
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更新日期:2020-12-04 00:00:00