Abstract:
:A recent highlight of genomics research has been the discovery of many families of transcripts which have function but do not code for proteins. An important group is long noncoding RNAs (lncRNAs), which are typically longer than 200 nt, and whose members originate from thousands of loci across genomes. We review progress in understanding the biogenesis and regulatory mechanisms of lncRNAs. We describe diverse computational and high throughput technologies for identifying and studying lncRNAs. We discuss the current knowledge of functional elements embedded in lncRNAs as well as insights into the lncRNA-based regulatory network in animals. We also describe genome-wide studies of large amount of lncRNAs in plants, as well as knowledge of selected plant lncRNAs with a focus on biotic/abiotic stress-responsive lncRNAs.
journal_name
Brief Funct Genomicsjournal_title
Briefings in functional genomicsauthors
Bai Y,Dai X,Harrison AP,Chen Mdoi
10.1093/bfgp/elu017subject
Has Abstractpub_date
2015-03-01 00:00:00pages
91-101issue
2eissn
2041-2649issn
2041-2657pii
elu017journal_volume
14pub_type
杂志文章,评审abstract::Gastric cancer remains the second most common cause of cancer-related death worldwide. Because of the poor prognosis of late-stage gastric cancer patients, it is imperative to develop new strategies to improve the survival rate of this disease. Currently, immunotherapy is considered as an innovative approach for cance...
journal_title:Briefings in functional genomics
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doi:10.1093/bfgp/ely019
更新日期:2019-03-22 00:00:00
abstract::Patterns of evolution in immune defense genes help to understand the evolutionary dynamics between hosts and pathogens. Multiple insect genomes have been sequenced, with many of them having annotated immune genes, which paves the way for a comparative genomic analysis of insect immunity. In this review, I summarize th...
journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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journal_title:Briefings in functional genomics
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更新日期:2017-07-01 00:00:00
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journal_title:Briefings in functional genomics
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更新日期:2012-01-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00
abstract::Recent data have revealed that the paradigmatic tumour suppressor gene RB1 on chromosome 13 is preferentially expressed from the maternal allele. Imprinted expression of RB1 is linked to a differentially methylated CpG island in intron 2 of this gene (CpG 85). On the paternal chromosome, CpG 85 is unmethylated and act...
journal_title:Briefings in functional genomics
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更新日期:2010-07-01 00:00:00
abstract::Gene Set Enrichment (GSE) is a computational technique which determines whether a priori defined set of genes show statistically significant differential expression between two phenotypes. Currently, the gene sets used for GSE are derived from annotation or pathway databases, which often contain computationally based ...
journal_title:Briefings in functional genomics
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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更新日期:2019-02-14 00:00:00
abstract::The presence of microchimeric cells is known for >100 years and well documented since decades. Earlier, microchimeric cells were mainly used for cell-based non-invasive prenatal diagnostics during early pregnancy. Microchimeric cells are also present beyond delivery and are associated to various autoimmune diseases, t...
journal_title:Briefings in functional genomics
pub_type: 杂志文章
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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更新日期:2016-11-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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更新日期:2018-09-27 00:00:00
abstract::Submitting sequences to the National Center for Biotechnology Information (NCBI) is an integral part of research and the publication process for many disciplines within the life sciences, and it will only become more important as sequencing technologies continue to improve. Here, I argue that the available infrastruct...
journal_title:Briefings in functional genomics
pub_type: 杂志文章
doi:10.1093/bfgp/elaa016
更新日期:2020-12-04 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/elv026
更新日期:2016-01-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/els016
更新日期:2012-07-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/elt002
更新日期:2013-05-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/elt011
更新日期:2013-05-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/elt034
更新日期:2014-01-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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更新日期:2016-05-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/elx029
更新日期:2018-07-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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journal_title:Briefings in functional genomics
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
abstract::Premature termination of transcription, or attenuation, is an efficient RNA-based regulatory strategy that is commonly used in bacterial organisms. Attenuators are generally located in the 50 untranslated regions of genes or operons and combine a Rho-independent terminator, controlling transcription, with an RNA eleme...
journal_title:Briefings in functional genomics
pub_type: 更正并重新发布的文章,杂志文章,评审
doi:10.1093/bfgp/elq008
更新日期:2010-03-01 00:00:00
abstract::The advent of high-throughput genomics techniques, along with the completion of genome sequencing projects, identification of protein-protein interactions and reconstruction of genome-scale pathways, has accelerated the development of systems biology research in the yeast organism Saccharomyces cerevisiae In particula...
journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/elv040
更新日期:2016-03-01 00:00:00
abstract::In order to better understand several cellular processes, it is helpful to study how various components make up the system. This systems perspective is supported by several modelling tools including network analysis. Networks of protein-protein interactions (PPI networks) offer a way to depict, visualize and quantify ...
journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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更新日期:2012-11-01 00:00:00
abstract::The use of genetically isolated populations can empower next-generation association studies. In this review, we discuss the advantages of this approach and review study design and analytical considerations of genetic association studies focusing on isolates. We cite successful examples of using population isolates in ...
journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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更新日期:2014-09-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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更新日期:2017-05-01 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章
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更新日期:2019-02-14 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章
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更新日期:2020-03-23 00:00:00