Abstract:
:In order to better understand several cellular processes, it is helpful to study how various components make up the system. This systems perspective is supported by several modelling tools including network analysis. Networks of protein-protein interactions (PPI networks) offer a way to depict, visualize and quantify the functioning and relative importance of particular proteins in cell function. The toolkit of network analysis ranges from the local indices describing individual proteins (as network nodes) to global indicators of system architecture, describing the total interaction system (as the whole network). We briefly introduce some of these network indices and present a case study where the connectedness and potential functional relationships between certain disease proteins are inferred. We argue that network analysis can be used, in general, to improve databases, to infer novel functions, to quantify positional importance and to support predictions in pathogenesis studies. The systems perspective and network analysis can be of particular importance in studying diseases with complex molecular processes.
journal_name
Brief Funct Genomicsjournal_title
Briefings in functional genomicsauthors
Jordán F,Nguyen TP,Liu WCdoi
10.1093/bfgp/els035subject
Has Abstractpub_date
2012-11-01 00:00:00pages
497-504issue
6eissn
2041-2649issn
2041-2657pii
els035journal_volume
11pub_type
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journal_title:Briefings in functional genomics
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