Abstract:
:Molecular network data are increasingly becoming available, necessitating the development of well performing computational tools for their analyses. Such tools enabled conceptually different approaches for exploring human diseases to be undertaken, in particular, those that study the relationship between a multitude of biomolecules within a cell. Hence, a new field of network biology has emerged as part of systems biology, aiming to untangle the complexity of cellular network organization. We survey current network analysis methods that aim to give insight into human disease.
journal_name
Brief Funct Genomicsjournal_title
Briefings in functional genomicsauthors
Janjić V,Pržulj Ndoi
10.1093/bfgp/els037subject
Has Abstractpub_date
2012-11-01 00:00:00pages
522-32issue
6eissn
2041-2649issn
2041-2657pii
els037journal_volume
11pub_type
杂志文章abstract::The specificity of protein-DNA interactions can be determined directly by sequencing the bound and unbound fractions in a standard binding reaction. The procedure is easy and inexpensive, and the accuracy can be high for thousands of sequences assayed in parallel. From the measurements, simple models of specificity, s...
journal_title:Briefings in functional genomics
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journal_title:Briefings in functional genomics
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journal_title:Briefings in functional genomics
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更新日期:2018-09-27 00:00:00
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
abstract::The involvement of epigenetic processes in the origin and progression of cancer is now widely appreciated. Consequently, targeting the enzymatic machinery that controls the epigenetic regulation of the genome has emerged as an attractive new strategy for therapeutic intervention. The development of epigenetic drugs re...
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journal_title:Briefings in functional genomics
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journal_title:Briefings in functional genomics
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更新日期:2020-12-04 00:00:00
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journal_title:Briefings in functional genomics
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更新日期:2012-01-01 00:00:00
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journal_title:Briefings in functional genomics
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更新日期:2018-03-01 00:00:00
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journal_title:Briefings in functional genomics
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更新日期:2010-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/elv049
更新日期:2016-05-01 00:00:00
abstract::Pluripotent embryonic stem (ES) cells are specialized cells with a dynamic chromatin structure, which is intimately connected with their pluripotency and physiology. In recent years somatic cells have been reprogrammed to a pluripotent state through over-expression of a defined set of transcription factors. These cell...
journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
doi:10.1093/bfgp/elq038
更新日期:2011-01-01 00:00:00
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更新日期:2015-03-01 00:00:00
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更新日期:2014-01-01 00:00:00
abstract::Hemagglutinin (HA) is a transmembrane protein of the influenza A virus and a key component in its life cycle. The protein allows the virus to enter a host cell by recognizing specific glycans attached to transmembrane proteins of the host, which leads to viral endocytosis. In recent years, significant progress has bee...
journal_title:Briefings in functional genomics
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更新日期:2018-11-26 00:00:00
abstract::High-throughput next-generation sequencing (NGS) technologies have rapidly generated a large volume of genomic data. To aid the development and evaluation of new statistical models and computational methods, NGS-based simulators have been proposed to construct better experimental workflows. However, the comparative pe...
journal_title:Briefings in functional genomics
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更新日期:2017-05-01 00:00:00
abstract::Neisseria meningitidis is a strictly human pathogen and is one of the major causes of septicemia and meningitis worldwide. Functional genomics approaches have been extensively applied to study how N. meningitidis adapts to grow and survive in different human niches encountered during the infection. DNA microarrays per...
journal_title:Briefings in functional genomics
pub_type: 杂志文章
doi:10.1093/bfgp/elt018
更新日期:2013-07-01 00:00:00
abstract::Premature termination of transcription, or attenuation, is an efficient RNA-based regulatory strategy that is commonly used in bacterial organisms. Attenuators are generally located in the 50 untranslated regions of genes or operons and combine a Rho-independent terminator, controlling transcription, with an RNA eleme...
journal_title:Briefings in functional genomics
pub_type: 更正并重新发布的文章,杂志文章,评审
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更新日期:2010-03-01 00:00:00
abstract::Epigenetic memory represents a natural mechanism whereby the identity of a cell is maintained through successive cell cycles, allowing the specification and maintenance of differentiation during development and in adult cells. Cancer is a loss or reversal of the stable differentiated state of adult cells and may be me...
journal_title:Briefings in functional genomics
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journal_title:Briefings in functional genomics
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更新日期:2017-01-01 00:00:00
abstract::Recent data have revealed that the paradigmatic tumour suppressor gene RB1 on chromosome 13 is preferentially expressed from the maternal allele. Imprinted expression of RB1 is linked to a differentially methylated CpG island in intron 2 of this gene (CpG 85). On the paternal chromosome, CpG 85 is unmethylated and act...
journal_title:Briefings in functional genomics
pub_type: 杂志文章,评审
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更新日期:2010-07-01 00:00:00