Abstract:
BACKGROUND:Several efforts are under way to develop and test methods for prospective drug safety monitoring using large, electronic claims databases. Prospective monitoring systems must incorporate signalling algorithms and techniques to mitigate confounding in order to minimize false positive and false negative signals due to chance and bias. OBJECTIVE:The aim of the study was to describe a prototypical targeted active safety monitoring system and apply the framework to three empirical examples. METHODS:We performed sequential, targeted safety monitoring in three known drug/adverse event (AE) pairs: (i) paroxetine/upper gastrointestinal (UGI) bleed; (ii) lisinopril/angioedema; (iii) ciprofloxacin/Achilles tendon rupture (ATR). Data on new users of the drugs of interest were extracted from the HealthCore Integrated Research Database. New users were matched by propensity score to new users of comparator drugs in each example. Analyses were conducted sequentially to emulate prospective monitoring. Two signalling rules--a maximum sequential probability ratio test and an effect estimate-based approach--were applied to sequential, matched cohorts to identify signals within the system. RESULTS:Signals were identified for all three examples: paroxetine/UGI bleed in the seventh monitoring cycle, within 2 calendar years of sequential data; lisinopril/angioedema in the second cycle, within the first monitoring year; ciprofloxacin/ATR in the tenth cycle, within the fifth year. CONCLUSION:In this proof of concept, our targeted, active monitoring system provides an alternative to systems currently in the literature. Our system employs a sequential, propensity score-matched framework and signalling rules for prospective drug safety monitoring and identified signals for all three adverse drug reactions evaluated.
journal_name
Drug Safjournal_title
Drug safetyauthors
Wahl PM,Gagne JJ,Wasser TE,Eisenberg DF,Rodgers JK,Daniel GW,Wilson M,Schneeweiss S,Rassen JA,Patrick AR,Avorn J,Bohn RLdoi
10.2165/11594770-000000000-00000subject
Has Abstractpub_date
2012-05-01 00:00:00pages
407-16issue
5eissn
0114-5916issn
1179-1942journal_volume
35pub_type
杂志文章相关文献
DRUG SAFETY文献大全abstract::Randomised clinical trials offer a unique opportunity for capturing safety information under a controlled setting that minimises biases in the comparison of different therapeutic options. Nevertheless, empirical evidence across diverse medical fields suggests that the reporting of safety information in clinical trials...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200225020-00002
更新日期:2002-01-01 00:00:00
abstract::Complex interactions exist amongst the various components of the neuroendocrine system in order to maintain homeostasis, energy balance and reproductive function. These components include the hypothalamus-pituitary- adrenal and -gonadal axes, the renin-angiotensin-aldosterone system, the sympathetic nervous system and...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200730030-00005
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9Is) were associated with a risk of neurocognitive adverse drug reactions (ADRs). OBJECTIVE:We aimed to investigate the occurrence of neuropsychiatric ADRs related to PCSK9Is. METHODS:We analyzed Individual Case Safety Reports (ICSRs) sent thr...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-020-01021-3
更新日期:2020-12-22 00:00:00
abstract:INTRODUCTION:Adverse event (AE) under-reporting has been a recurrent issue raised during health authorities Good Clinical Practices (GCP) inspections and audits. Moreover, safety under-reporting poses a risk to patient safety and data integrity. The current clinical Quality Assurance (QA) practices used to detect AE un...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-019-00831-4
更新日期:2019-09-01 00:00:00
abstract::Antibiotic-associated pseudomembranous colitis is an uncommon but potentially serious adverse reaction, resulting in acute diarrhoea and characterised by colonic pseudomembranes. A direct relationship between the disease, recent antibiotic therapy and proliferation of Clostridium difficile in the colonic lumen was est...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199106050-00004
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Selective serotonin reuptake inhibitors (SSRIs) are frequently prescribed in the elderly due to a more favorable risk profile than other antidepressants (ADs). However, SSRIs are associated with an increased risk of gastrointestinal bleeding, while evidence on the risk of hemorrhagic stroke (HS) ...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-019-00837-y
更新日期:2019-09-01 00:00:00
abstract::Childhood hyperactivity is a common behavioural complaint. The therapeutic options for physicians caring for children with hyperactivity are considerable and varied; current recommendations call for a multidisciplinary approach, including when necessary the use of drug therapy. Central nervous system stimulants are th...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199309010-00004
更新日期:1993-07-01 00:00:00
abstract:INTRODUCTION:As asthma medications are frequently prescribed for children, knowledge of the safety of these drugs in the paediatric population is important. Although spontaneous reports cannot be used to prove causality of adverse events, they are important in the detection of safety signals. OBJECTIVE:Our objective w...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-019-00870-x
更新日期:2020-01-01 00:00:00
abstract::Acute intoxication with inorganic fluoride disrupts numerous physiological systems. As a potent acid it acts corrosively on the skin and mucous membranes, producing severe burns. As the most electronegative element it tightly binds many cations essential to homeostasis, producing, for example, profound hypocalcaemia a...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199005020-00001
更新日期:1990-03-01 00:00:00
abstract:: ...
journal_title:Drug safety
pub_type: 评论,信件
doi:10.1007/s40264-018-0670-2
更新日期:2018-06-01 00:00:00
abstract::After 2002, an association between stroke and antipsychotic use was reported in clinical trials and large database studies. This review considers previous quantitative reviews, newly published clinical trials, and recent observational cohort and case-control studies, and focuses on the clinical significance of the ris...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/11319120-000000000-00000
更新日期:2010-04-01 00:00:00
abstract::The last decade has seen an increase in the trend of HMG-CoA reductase inhibitor (statin) usage in the Western world, which does not come as a surprise noting that the latest American Heart Association heart and stroke statistics indicate an alarming prevalence of 80 million Americans (one in three) with one or more ...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/11584380-000000000-00000
更新日期:2011-01-01 00:00:00
abstract::Eosinophils play a pivotal role in the inflammatory pathology of asthma and have been the target of new biologic treatments for patients with eosinophilic asthma. Given the central role of interleukin (IL)-5 in the eosinophil lifecycle, several therapies directed against the IL-5 pathway have been developed, including...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.1007/s40264-020-00926-3
更新日期:2020-05-01 00:00:00
abstract:INTRODUCTION:New pharmacovigilance legislation was adopted in the EU in 2010 and became operational in July 2012. The legislation placed an obligation on all national competent authorities (NCAs) and marketing authorisation holders (MAHs) to record and report cases of suspected adverse drug reactions (ADRs) received fr...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-017-0534-1
更新日期:2017-07-01 00:00:00
abstract:INTRODUCTION:Adverse drug reactions (ADRs) are unintended reactions caused by a drug or combination of drugs taken by a patient. The current safety surveillance system relies on spontaneous reporting systems (SRSs) and more recently on observational health data; however, ADR detection may be delayed and lack geographic...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-020-00943-2
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:The case-population approach or population-based case-cohort approach is derived from the case-control design and consists of comparing past exposure to a given risk factor in subjects presenting a given disease or symptom (cases) with the exposure rate to this factor in the whole cohort or in the source pop...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/11592140-000000000-00000
更新日期:2011-10-01 00:00:00
abstract::Rhythm control in atrial fibrillation (AF) can be achieved using pharmacological therapy. Amiodarone is the most efficacious anti-arrhythmic agent; however, its use is limited due to an unfavourable safety profile, including pro-arrhythmia, thyroid, liver, skin and pulmonary complications. Dronedarone, which is struct...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.1007/s40264-012-0012-8
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVES:Difficulty sleeping is a recognised tobacco withdrawal symptom, but sleep problems, like application site reactions, are commonly reported as adverse reactions to transdermal nicotine therapy. However, no studies have examined potential predictive factors associated with the occurrence of expected adverse ex...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/00002018-199920060-00007
更新日期:1999-06-01 00:00:00
abstract::Drug interactions in patients receiving multiple drug regimens are a constant concern for the clinician. With the increased availability of new drugs and their concomitant use with other drugs, there has been a rise in the potential for adverse drug interactions as demonstrated by the recent withdrawals of newly marke...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200124100-00001
更新日期:2001-01-01 00:00:00
abstract:INTRODUCTION:Detecting signals of safety concerns associated with complementary medicines (CMs) relies on spontaneous reports submitted by health professionals and patients/consumers. Community pharmacists are well placed to identify and report suspected adverse drug reactions (ADRs) associated with CMs, but pharmacist...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-020-00980-x
更新日期:2020-11-01 00:00:00
abstract::Histone deacetylases (HDACs) are expressed at increased levels in cells of various malignancies, and the use of HDAC inhibitors has improved outcomes in patients with haematological malignancies (T-cell lymphomas and multiple myeloma). However, they are not as effective in solid tumours. Five agents are currently appr...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.1007/s40264-018-0773-9
更新日期:2019-02-01 00:00:00
abstract::Pharmacotherapy in pregnant women is often necessary to treat chronic or relapsing depression or anxiety disorders. Studies that have evaluated the safety of selective serotonin reuptake inhibitors (SSRIs) in early pregnancy have not shown an enhanced risk of major congenital malformations and these results may have c...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200528070-00002
更新日期:2005-07-01 00:00:00
abstract::Several recent case control studies have shown an excess rate of venous thromboembolism in women using third generation progestogen-containing combined contraceptive pills compared to second generation combined contraceptive pills. This excess is about 1 in 10,000 women per year of use. It is likely that second and th...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/00002018-199716020-00001
更新日期:1997-02-01 00:00:00
abstract:INTRODUCTION:Pharmacovigilance includes analysis of large databases of information on drugs and events using algorithms that detect disproportional frequencies of associations. In order to test such algorithms, attempts have been made to provide canonical reference lists of so-called 'positive controls' and 'negative c...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-016-0392-2
更新日期:2016-05-01 00:00:00
abstract::The non-vitamin K antagonist oral anticoagulants (NOACs) are used for thromboembolic prophylaxis of patients with atrial fibrillation and in the treatment as well as secondary prophylaxis of patients with venous thromboembolism. Even though NOACs have a better safety profile than vitamin K antagonists (VKAs), there wi...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.1007/s40264-015-0357-x
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Drug-drug interactions (DDIs) are a well known risk factor for adverse drug reactions. HMG-CoA reductase inhibitors ('statins') are a cornerstone in the treatment of dyslipidaemia and patients with dyslipidaemia are concomitantly treated with a variety of additional drugs. Since DDIs are associated with adve...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/00002018-200528030-00007
更新日期:2005-01-01 00:00:00
abstract::After initial enthusiasm, the use of monoamine oxidase inhibitors (MAOIs) has been limited by the wide range of MAOI-drug and MAOI-food interactions that are possible, particularly with sympathomimetic medications or tyramine-containing foods, resulting in hypertensive reactions. Despite their clinical benefits, this ...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199614040-00002
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:Individual case reports of suspected harm from medicines are fundamental for signal detection in postmarketing surveillance. Their effective analysis requires reliable data and one challenge is report duplication. These are multiple unlinked records describing the same suspected adverse drug reaction (ADR) i...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-014-0146-y
更新日期:2014-04-01 00:00:00
abstract::There are 2 isoenzymes of cyclo-oxygenase (COX). There is a constitutive enzyme COX-1 which has a wide tissue distribution. In addition there is an inducible enzyme COX-2 which has a restricted tissue distribution. The inducible enzyme COX-2 is responsible for the generation of prostaglandins at sites of tissue inflam...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199615040-00003
更新日期:1996-10-01 00:00:00
abstract::Current antiretroviral therapy has lead to longer survival in patients infected with HIV, but it is also associated with new and important problems. Body fat redistribution and metabolic abnormalities, the so-called lipodystrophy syndrome, are among the most prevalent and worrisome ones. While an increasing number of ...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200124030-00001
更新日期:2001-01-01 00:00:00