Abstract:
:Several recent case control studies have shown an excess rate of venous thromboembolism in women using third generation progestogen-containing combined contraceptive pills compared to second generation combined contraceptive pills. This excess is about 1 in 10,000 women per year of use. It is likely that second and third generation pills have been preferentially prescribed to users who have varying susceptibility to venous thromboembolism and that this may account for at least part of the observed differences. In practice, it is essential that all women using combined oral contraceptive pills have a thorough history taken to exclude any contraindications or risk factors. Each client should be counselled about the risks and benefits of oral contraception. In New Zealand, the Ministry of Health has recommended that prescribers for women starting a contraceptive pill for the first time should consider a pill that does not contain a third generation progestogen. Women already receiving a third generation pill may elect to continue that pill after the differential rates of venous thromboembolism have been discussed.
journal_name
Drug Safjournal_title
Drug safetyauthors
Roke Cdoi
10.2165/00002018-199716020-00001subject
Has Abstractpub_date
1997-02-01 00:00:00pages
79-87issue
2eissn
0114-5916issn
1179-1942journal_volume
16pub_type
杂志文章相关文献
DRUG SAFETY文献大全abstract:OBJECTIVE:During proton pump inhibitor (PPI) use, in clinical trials, headache is one of the most frequently reported adverse events (frequency 1.3 to 8.8%), while results of one observational study indicate that headache is the fifth most frequently reported adverse event (incidence densities 2.5 to 4.6 per 1000 patie...
journal_title:Drug safety
pub_type: 临床试验,杂志文章
doi:10.2165/00002018-200225040-00005
更新日期:2002-01-01 00:00:00
abstract:INTRODUCTION:Non-steroidal anti-inflammatory drugs are associated with a dose and duration-dependent coronary risk. There is little information concerning analgesic-dose ibuprofen, among the most widely used drugs worldwide. OBJECTIVE:Our objective was to measure the risks of acute coronary syndrome (ACS) after dispen...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-018-0686-7
更新日期:2018-11-01 00:00:00
abstract::Drug-induced QT interval prolongation is now a major concern in safety pharmacology. Regulatory authorities such as the US FDA and the European Medicines Agency require in vitro testing of all drug candidates against the potential risk for QT interval prolongation prior to clinical trials. Common in vitro methods incl...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200427110-00002
更新日期:2004-01-01 00:00:00
abstract::To determine the pattern of and the risk factors for adverse drug reactions (ADRs) in Hong Kong, a prospective study of acute admissions to 2 general medical wards at the Prince of Wales Hospital was undertaken. Of the 1701 admissions included in this study, 74 (4.4%) were attributed to ADRs. Sulphonylureas, nonsteroi...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/00002018-199207030-00008
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:Rituximab is a monoclonal antibody approved for treating CD20-positive B-cell non-Hodgkin's lymphoma and rheumatoid arthritis but is used off-label for treating many autoimmune disorders, including multiple sclerosis (MS). Similarly to other monoclonal antibodies, the incidence of infusion-related reactions ...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/11585960-000000000-00000
更新日期:2011-02-01 00:00:00
abstract::Pharmacovigilance is the science of monitoring the effects of medicinal products to identify and evaluate potential adverse reactions and provide necessary and timely risk mitigation measures. Intelligent automation technologies have a strong potential to automate routine work and to balance resource use across safety...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-020-01030-2
更新日期:2021-02-01 00:00:00
abstract::Adverse drug effects are manifold and heterogenous. Many situations may hamper the signalling (i.e. the detection of early warning signs) of adverse effects and new signals often differ from previous experiences. Signals have qualitative and quantitative aspects. Different categories of adverse effects need different ...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199716060-00002
更新日期:1997-06-01 00:00:00
abstract::Older people in the UK receive a disproportionate amount of medication. They comprise 18% of the population but receive 45% of all prescription items. Not surprisingly they experience drug-related illnesses - in 1980, 1 in 10 admissions to acute geriatric units were wholly or partly due to adverse drug reactions. Drug...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199819040-00001
更新日期:1998-10-01 00:00:00
abstract::The prognosis is generally poor for patients who experience a cardiac arrest. The most common causes of sudden cardiac arrest are massive pulmonary embolism (PE) and acute myocardial infarction (MI). While thrombolysis is a first-line treatment option in massive PE and acute MI, cardiopulmonary resuscitation (CPR) has...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200326060-00001
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:In the UK, spontaneous reporting of suspected adverse drug reactions (ADRs) by healthcare professionals has been in operation since 1964 through the Yellow Card Scheme (YCS). From 2005, patients themselves have been able to submit Yellow Card reports. OBJECTIVE:To compare patient characteristics, suspected ...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/11536510-000000000-00000
更新日期:2010-09-01 00:00:00
abstract::Gastroesophageal reflux is one of the most common reasons for referrals to paediatricians or paediatric gastroenterologists. Gastric acid-buffering agents, mucosal surface barriers and gastric anti-secretory agents are the main groups of medications currently used for treating gastroesophageal reflux disease (GERD) in...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.1007/s40264-014-0154-y
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Potential severe liver injury is identified in clinical trials by ALT >3 × upper limits of normal (ULN) and total bilirubin >2 × ULN, and termed 'Hy's Law' by the US FDA. However, there is limited evidence or validation of these thresholds in clinical trial populations. Using liver chemistry data from clinic...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/BF03261982
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:At time of approval, knowledge of the full benefit risk of any drug is limited, in particular with regards to safety. Post-approval surveillance of potential drug safety concerns is recognized as an important task of regulatory agencies. For innovative, often first-in-class drugs, safety knowledge at time of...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-013-0094-y
更新日期:2013-11-01 00:00:00
abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed to women of child-bearing age. Three case series highlight the possibility of a link between NSAIDs and reversible infertility. The pharmacological target of NSAIDs is cyclo-oxygenase (COX), which catalyses the first rate-limiting step in the prod...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200225080-00001
更新日期:2002-01-01 00:00:00
abstract::Although heart failure is predominantly caused by cardiovascular conditions such as hypertension, coronary heart disease and valvular heart disease, it can also be an adverse reaction induced by drug therapy. In addition, some drugs have the propensity to adversely affect haemodynamic mechanisms in patients with an al...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200629070-00003
更新日期:2006-01-01 00:00:00
abstract::The complications of failure, neural injury and local anaesthetic toxicity are common to all regional anaesthesia techniques, and individual techniques are associated with specific complications. All potential candidates for regional anaesthesia should be thoroughly evaluated and informed of potential complications. I...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200124060-00002
更新日期:2001-01-01 00:00:00
abstract::Pharmacotherapy in pregnant women is often necessary to treat chronic or relapsing depression or anxiety disorders. Studies that have evaluated the safety of selective serotonin reuptake inhibitors (SSRIs) in early pregnancy have not shown an enhanced risk of major congenital malformations and these results may have c...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200528070-00002
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Although systems to collect information about suspected adverse drug reactions (ADRs) were established in many countries and by the WHO in the 1960s, few studies have examined reported ADRs related to national income. OBJECTIVE:The aim of the study was to characterize ADRs reported to the WHO-ADR database, ...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/BF03262002
更新日期:2012-12-01 00:00:00
abstract::Cutaneous adverse drug reactions are a frequent occurrence and have been reported in more than 2% of hospitalised patients. Among the most commonly involved drugs are sulphonamides, penicillins, anticonvulsants and non-steroidal anti-inflammatory drugs. Two groups of mechanisms are involved in the pathogenesis of drug...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199005010-00005
更新日期:1990-01-01 00:00:00
abstract::A spectrum of adverse drug reactions that are caused by the combined action of drugs and viruses has been described: ampicillin rash in acute infectious mononucleosis; Reye's syndrome; hypersensitivity reactions to sulphonamides in patients with HIV infection; drug-induced agranulocytosis; paracetamol (acetaminophen) ...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199716010-00001
更新日期:1997-01-01 00:00:00
abstract::Absolute and functional iron deficiency is the most common cause of epoetin (recombinant human erythropoietin) hyporesponsiveness in renal failure patients. Diagnostic procedures for determining iron deficiency include measurement of serum iron levels, serum ferritin levels, saturation of transferrin and percentage of...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199717040-00004
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:Acute liver failure is idiopathic and drug-related in, respectively, around 50 and 15 % of children. Population-based, epidemiologic data about the pattern of disease manifestation and incidence of less severe acute liver injury, either idiopathic or potentially drug-attributed are limited in children and ad...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-013-0045-7
更新日期:2013-10-01 00:00:00
abstract::Transdermal fentanyl is effective and well tolerated for the treatment of chronic pain caused by malignancy and non-malignant conditions when administered according to the manufacturer's recommendations. Compared with oral opioids, the advantages of transdermal fentanyl include a lower incidence and impact of adverse ...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200326130-00004
更新日期:2003-01-01 00:00:00
abstract::Randomised clinical trials offer a unique opportunity for capturing safety information under a controlled setting that minimises biases in the comparison of different therapeutic options. Nevertheless, empirical evidence across diverse medical fields suggests that the reporting of safety information in clinical trials...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200225020-00002
更新日期:2002-01-01 00:00:00
abstract::After initial enthusiasm, the use of monoamine oxidase inhibitors (MAOIs) has been limited by the wide range of MAOI-drug and MAOI-food interactions that are possible, particularly with sympathomimetic medications or tyramine-containing foods, resulting in hypertensive reactions. Despite their clinical benefits, this ...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199614040-00002
更新日期:1996-04-01 00:00:00
abstract::The use of triple regimens, often called highly active antiretroviral therapy (HAART), generally involving 2 nucleoside analogues and an HIV protease inhibitor, have been endorsed as the standard of care for persons with HIV initiating therapy by a number of sets of international guidelines. The widespread availabilit...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199920040-00002
更新日期:1999-04-01 00:00:00
abstract::A number of affluent countries are moving to eliminate thiomersal (thimerosal), an ethylmercury preservative, from vaccines as a precautionary measure because of concerns about the potential adverse effects of mercury in infants. The WHO advocates continued use of thiomersal-containing vaccines in developing countries...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200528020-00001
更新日期:2005-01-01 00:00:00
abstract::The mitochondrial respiratory chain (MRC) and ATP synthase (complex V) play an essential role in cellular energy production by the process of oxidative phosphorylation. In addition to inborn errors of metabolism, as well as secondary causes from disease pathophysiology, an impairment of oxidative phosphorylation can r...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.1007/s40264-016-0417-x
更新日期:2016-07-01 00:00:00
abstract::Although travellers' diarrhoea can sometimes be associated with postinfectious complications, the condition is typically self-limiting. The infectious-diarrhoea guidelines subcommittees of the Infectious Disease Society of America and the American College of Gastroenterology recommend empirical antibacterial therapy f...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200629030-00004
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:Reframing side-effect information in patient information leaflets (PILs) in terms of those who remain side-effect-free may reduce negative expectations and side-effects, although there are concerns this may impact informed consent. This study compared two versions of positively framed PILs with current pra...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-020-00959-8
更新日期:2020-10-01 00:00:00