Abstract:
BACKGROUND:Drug-drug interactions (DDIs) are a well known risk factor for adverse drug reactions. HMG-CoA reductase inhibitors ('statins') are a cornerstone in the treatment of dyslipidaemia and patients with dyslipidaemia are concomitantly treated with a variety of additional drugs. Since DDIs are associated with adverse reactions, we performed a cross-sectional study to assess the prevalence of potentially critical drug-drug and drug-statin interactions in an outpatient adult population with dyslipidaemia. METHODS:Data from patients with dyslipidaemia treated with a statin were collected from 242 practitioners from different parts of Switzerland. The medication list was screened for potentially harmful DDIs with statins or other drugs using an interactive electronic drug interaction program. RESULTS:We included 2742 ambulatory statin-treated patients (mean age +/- SD 65.1 +/- 11.1 years; 61.6% males) with (mean +/- SD) 3.2 +/- 1.6 diagnoses and 4.9 +/- 2.4 drugs prescribed. Of those, 190 patients (6.9%) had a total of 198 potentially harmful drug-statin interactions. Interacting drugs were fibrates or nicotinic acid (9.5% of patients with drug-statin interactions), cytochrome P450 (CYP) 3A4 inhibitors (70.5%), digoxin (22.6%) or ciclosporin (cyclosporine) [1.6%]. The proportion of patients with a potential drug-statin interaction was 12.1% for simvastatin, 10.0% for atorvastatin, 3.8% for fluvastatin and 0.3% for pravastatin. Additionally, the program identified 393 potentially critical non-statin DDIs in 288 patients. CONCLUSIONS:CYP3A4 inhibitors are the most frequent cause of potential drug interactions with statins. As the risk for developing rhabdomyolysis is increased in patients with drug-statin interactions, clinicians should be aware of the most frequently observed drug-statin interactions and how these interactions can be avoided.
journal_name
Drug Safjournal_title
Drug safetyauthors
Rätz Bravo AE,Tchambaz L,Krähenbühl-Melcher A,Hess L,Schlienger RG,Krähenbühl Sdoi
10.2165/00002018-200528030-00007keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
263-75issue
3eissn
0114-5916issn
1179-1942pii
2837journal_volume
28pub_type
杂志文章相关文献
DRUG SAFETY文献大全abstract:INTRODUCTION:Adverse drug reactions (ADRs) are unintended reactions caused by a drug or combination of drugs taken by a patient. The current safety surveillance system relies on spontaneous reporting systems (SRSs) and more recently on observational health data; however, ADR detection may be delayed and lack geographic...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-020-00943-2
更新日期:2020-09-01 00:00:00
abstract::Anaemia is common in patients with haematological malignancy, occurring in the majority of patients with malignant disease who are treated with chemotherapy. Most patients will have their anaemia attributed to the cytokine-mediated anaemia of chronic disease. Many of these patients with anaemia will be symptomatic wit...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200225070-00006
更新日期:2002-01-01 00:00:00
abstract::The introduction of MedDRA, the Medical Dictionary for Regulatory Activities, as a standardised terminology may have a major impact on the performance of risk management. Thus, MedDRA is likely to have an important effect on the analysis of clinical trial safety data. Review of the most commonly used terms in clinical...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200427080-00010
更新日期:2004-01-01 00:00:00
abstract::Aspirin (acetylsalicylic acid) and other nonsteroidal anti-inflammatory drugs (NSAIDs) cause deterioration in respiratory function in approximately 10% of adults with asthma and a smaller proportion of children with asthma. We propose evidence-based guidelines for the safe use of NSAIDs in individuals with asthma foll...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200124110-00004
更新日期:2001-01-01 00:00:00
abstract:INTRODUCTION:An often key component to coordinating surveillance activities across distributed networks is the design and implementation of a common data model (CDM). The purpose of this study was to evaluate two drug safety surveillance CDMs from an ecosystem perspective to better understand how differences in CDMs an...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-015-0297-5
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Newly approved drugs, in comparison with older drugs, are more often prescribed to patients who have not responded satisfactorily to established related drugs or as first-line therapy to patients with a high baseline risk for adverse outcomes (i.e. channelling). However, these patients are less likely to ben...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/00002018-200831020-00004
更新日期:2008-01-01 00:00:00
abstract::Dental caries is defined as a pathological breakdown of the tooth. It is an infectious phenomenon involving a multifactorial aetiology. The impact of drugs on cariogenic risk has been poorly investigated. ...
journal_title:Drug safety
pub_type: 杂志文章,已发布勘误
doi:10.1007/s40264-018-0672-0
更新日期:2018-08-01 00:00:00
abstract::Review of the medical records of 2 major adult teaching hospitals for a 4-year period revealed 33 instances of carbamazepine overdose. These patients had a mean age of 30 years and 58% were known epileptics. They ingested a mean of 12g carbamazepine (range 1.6 to 45g), with 51% of cases involving other drugs, particul...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199308010-00010
更新日期:1993-01-01 00:00:00
abstract::It has been more than 25 years since an adverse drug reaction (ADR) monitoring agency was first established in China. In the past few years, the National ADR Monitoring System (NADRMS) has developed rapidly in the country. However, this system has not been reviewed in detail in the literature. Our aim was to demonstra...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.1007/s40264-016-0446-5
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Rituximab is a monoclonal antibody approved for treating CD20-positive B-cell non-Hodgkin's lymphoma and rheumatoid arthritis but is used off-label for treating many autoimmune disorders, including multiple sclerosis (MS). Similarly to other monoclonal antibodies, the incidence of infusion-related reactions ...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/11585960-000000000-00000
更新日期:2011-02-01 00:00:00
abstract::The treatment of type 2 diabetes mellitus remains controversial. Since most patients are overweight or obese, regimens based on dietary modification and increased physical exercise are logical and safe treatment approaches. However, the long term impact of these interventions is frequently disappointing and pharmacoth...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199921010-00002
更新日期:1999-07-01 00:00:00
abstract::Since 2008, the direct-acting oral anticoagulants (DOACs) have expanded the therapeutic options of cardiovascular diseases with recognized clinical and epidemiological impact, such as non-valvular atrial fibrillation (NVAF) and venous thromboembolism (VTE), and also in the preventive setting of orthopedic surgical pat...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.1007/s40264-016-0464-3
更新日期:2016-12-01 00:00:00
abstract::Absolute and functional iron deficiency is the most common cause of epoetin (recombinant human erythropoietin) hyporesponsiveness in renal failure patients. Diagnostic procedures for determining iron deficiency include measurement of serum iron levels, serum ferritin levels, saturation of transferrin and percentage of...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199717040-00004
更新日期:1997-10-01 00:00:00
abstract::Thallium poisoning seldom occurs in Spain. This article reports 5 cases of thallium poisoning, of which 4 of the patients belonged to the same family. The cases occurred in or near Granada between 1985 and 1987. The symptoms were initially gastrointestinal (vomiting, abdominal pain, gastrointestinal haemorrhage, etc.)...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/00002018-199005050-00006
更新日期:1990-09-01 00:00:00
abstract::Blinatumomab is the first-and-only Food and Drug Administration (FDA)-approved cluster of differentiation (CD) 19-directed CD3 bispecific T-cell engager (BiTE®) immunotherapy. It is currently FDA approved for the treatment of adults and children with Philadelphia chromosome-positive (Ph+) and Philadelphia chromosome-n...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.1007/s40264-018-0760-1
更新日期:2019-05-01 00:00:00
abstract::Betahistine is a structural analogue of histamine that is prescribed for the treatment of vestibular disorders such as Ménière's disease and the symptomatic treatment of vertigo. It is estimated from sales information that >130 million patients have been exposed to the drug since its registration in 1968. In this revi...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/00002018-200629110-00004
更新日期:2006-01-01 00:00:00
abstract::Misoprostol, a prostaglandin E(1) analogue, is widely used in the US and other countries for cervical ripening and labour induction. Its use for these indications is not approved by the US Food and Drug Administration (FDA). The manufacturer of misoprostol issued a letter to American healthcare providers in August 200...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200225090-00005
更新日期:2002-01-01 00:00:00
abstract:INTRODUCTION:Pharmacovigilance, the monitoring of drug safety after marketing approval, highly depends on the adequate reporting of adverse drug reactions (ADRs). To improve pharmacovigilance awareness and future ADR reporting among medical students, we developed and evaluated a student-run pharmacovigilance programme....
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-016-0502-1
更新日期:2017-05-01 00:00:00
abstract::There is clear experimental evidence that antibiotics increase the bioavailability of endotoxin from Gram-negative bacteria. In this review, data for 2 variables, level of endotoxin and level of bacteria, at the time point closest to 2 hours post-antibiotic exposure were abstracted as a change from baseline readings f...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199512030-00004
更新日期:1995-03-01 00:00:00
abstract:INTRODUCTION:Electronic healthcare databases (EHDs) are used increasingly for post-marketing drug safety surveillance and pharmacoepidemiology in Europe and North America. However, few studies have examined the potential of these data sources in China. METHODS:Three major types of EHDs in China (i.e., a regional commu...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-017-0589-z
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The roll out of various public health programmes involving mass administration of medicines calls for the deployment of responsive pharmacovigilance systems to permit identification of signals of rare or even common adverse reactions. In developing countries in Africa, these systems are mostly absent and the...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/00002018-200831100-00005
更新日期:2008-01-01 00:00:00
abstract::Antibiotic-associated pseudomembranous colitis is an uncommon but potentially serious adverse reaction, resulting in acute diarrhoea and characterised by colonic pseudomembranes. A direct relationship between the disease, recent antibiotic therapy and proliferation of Clostridium difficile in the colonic lumen was est...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199106050-00004
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Screening large databases of spontaneous case reports of possible adverse drug reactions (ADRs) is an established method of identifying hitherto unknown adverse effects of medicinal products; however, there is a lack of consensus concerning the value of formal statistical screening procedures in guiding such...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/11534410-000000000-00000
更新日期:2010-06-01 00:00:00
abstract::Two Japanese regulatory agencies, the Ministry of Health, Labour and Welfare and the Pharmaceuticals and Medical Devices Agency announced the implementation of a new review system called 'Conditional Approval,' specifically for the emerging field of regenerative medicine, in an amendment to the Pharmaceutical Affairs ...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.1007/s40264-017-0517-2
更新日期:2017-06-01 00:00:00
abstract::Although heart failure is predominantly caused by cardiovascular conditions such as hypertension, coronary heart disease and valvular heart disease, it can also be an adverse reaction induced by drug therapy. In addition, some drugs have the propensity to adversely affect haemodynamic mechanisms in patients with an al...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200629070-00003
更新日期:2006-01-01 00:00:00
abstract::It is a major clinical and public health problem that there is no clear strategy as to how we best make use of information obtained when pregnant women take drugs. For this reason, some pregnant women are not treated as they should be and some are given drugs they should not use. We suggest a monitoring system that co...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/00002018-200225010-00003
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:The use of data mining has increased among regulators and pharmaceutical companies. The incremental value of data mining as an adjunct to traditional pharmacovigilance methods has yet to be demonstrated. Specifically, the utility in identifying new safety signals and the resources required to do so have not ...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/11319000-000000000-00000
更新日期:2010-02-01 00:00:00
abstract::Quinolones are a class of antibacterial agents for the treatment of several infectious diseases (e.g. urinary and respiratory tract infections). They are used worldwide due to their broad spectrum of activity, high bioavailability and good safety profile. The safety profile varies from quinolone to quinolone. The aim ...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/11587280-000000000-00000
更新日期:2011-06-01 00:00:00
abstract::Monobactams and carbapenems are 2 classes of beta-lactam antibiotics that were introduced in the 1980s. This review considers the monobactam aztreonam and the carbapenems imipenem and meropenem. Imipenem is administered together with cilastatin, which inhibits the enzymatic breakdown of imipenem in the kidney. The ant...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199512050-00003
更新日期:1995-05-01 00:00:00
abstract::After initial enthusiasm, the use of monoamine oxidase inhibitors (MAOIs) has been limited by the wide range of MAOI-drug and MAOI-food interactions that are possible, particularly with sympathomimetic medications or tyramine-containing foods, resulting in hypertensive reactions. Despite their clinical benefits, this ...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199614040-00002
更新日期:1996-04-01 00:00:00