Abstract:
:Review of the medical records of 2 major adult teaching hospitals for a 4-year period revealed 33 instances of carbamazepine overdose. These patients had a mean age of 30 years and 58% were known epileptics. They ingested a mean of 12g carbamazepine (range 1.6 to 45g), with 51% of cases involving other drugs, particularly alcohol. The clinical manifestations of toxicity formed a recognisable clinical picture of diminished conscious state (100% of patients), mydriasis (42%), abnormal muscle tone and tendon reflexes (55%) and ataxia, nystagmus or ophthalmoplegia (48%). 24% of cases were complicated by seizures. The incidence of hyperglycaemia and hypokalaemia were related to higher drug concentrations. 12% showed hyponatraemia and 50% had transient evidence of hepatic dysfunction. The pharmacokinetic properties of carbamazepine play a role in determining management strategies. Management is largely supportive through avoidance of drug interactions, large doses of activated charcoal, careful airway management and correction of electrolyte disturbances.
journal_name
Drug Safjournal_title
Drug safetyauthors
Seymour JFdoi
10.2165/00002018-199308010-00010subject
Has Abstractpub_date
1993-01-01 00:00:00pages
81-8issue
1eissn
0114-5916issn
1179-1942journal_volume
8pub_type
杂志文章,评审相关文献
DRUG SAFETY文献大全abstract:INTRODUCTION:Previously, an app has been developed for healthcare professionals (HCPs) and patients to report adverse drug reactions (ADRs) to national medicines agencies and to receive drug safety information. OBJECTIVE:This study aimed to assess (1) European HCPs' and patients' interest in an app for this two-way ri...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-018-0648-0
更新日期:2018-07-01 00:00:00
abstract::Drug safety is not a matter for healthcare professionals alone. Patients are also involved, at three different levels: (i) in the behaviours patients adopt to reduce the adverse effects of the drugs; (ii) in regard to what some doctors say to their patients about drug risks; and (iii) in what the pharmaceutical indust...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/11538320-000000000-00000
更新日期:2010-08-01 00:00:00
abstract::Monobactams and carbapenems are 2 classes of beta-lactam antibiotics that were introduced in the 1980s. This review considers the monobactam aztreonam and the carbapenems imipenem and meropenem. Imipenem is administered together with cilastatin, which inhibits the enzymatic breakdown of imipenem in the kidney. The ant...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199512050-00003
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:Following reports of sudden death in patients taking medication to treat attention-deficit hyperactivity disorder (ADHD), this study aimed to identify cases of death in patients prescribed stimulants and atomoxetine and to determine any association between these and sudden death. METHOD:The UK General Pract...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/11317630-000000000-00000
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:One-third of adults in the USA experience chronic pain and use a variety of painkillers, such as nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and opioids. However, some serious adverse events (AEs), such as cardiovascular incidents, overdose, and death, have been found to be related to pai...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-017-0611-5
更新日期:2018-03-01 00:00:00
abstract::The available antihyperlipidaemic drugs are generally safe and effective, and major systemic adverse effects are uncommon. However, because of their complex mechanisms of action, careful monitoring is required to identify and correct potential drug interactions. Bile acid sequestrants are the most difficult of these a...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199411050-00002
更新日期:1994-11-01 00:00:00
abstract::Boxed warnings-also known as "black box" warnings-can be a powerful tool in communicating drug risks to physicians and patients. The overall number of boxed warnings has grown in recent years as the US Food and Drug Administration (FDA) has approved more drugs on the basis of limited pre-marketing information and as n...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-016-0419-8
更新日期:2016-08-01 00:00:00
abstract::The complications of failure, neural injury and local anaesthetic toxicity are common to all regional anaesthesia techniques, and individual techniques are associated with specific complications. All potential candidates for regional anaesthesia should be thoroughly evaluated and informed of potential complications. I...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200124060-00002
更新日期:2001-01-01 00:00:00
abstract::Adverse drug reactions (ADRs) cause considerable mortality and morbidity but no recent reviews are currently available for the European region. Therefore, we performed a review of all epidemiological studies quantifying ADRs in a European setting that were published between 1 January 2000 and 3 September 2014. Include...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.1007/s40264-015-0281-0
更新日期:2015-05-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVE:Pharmacovigilance requirements for biologics mandate that EU Member States shall ensure that any biologic that is the subject of a suspected adverse drug reaction (ADR) is identifiable by brand name and batch number. Recent studies showed that brand name identification is well established, wh...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-015-0383-8
更新日期:2016-02-01 00:00:00
abstract::Blinatumomab is the first-and-only Food and Drug Administration (FDA)-approved cluster of differentiation (CD) 19-directed CD3 bispecific T-cell engager (BiTE®) immunotherapy. It is currently FDA approved for the treatment of adults and children with Philadelphia chromosome-positive (Ph+) and Philadelphia chromosome-n...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.1007/s40264-018-0760-1
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Newly approved drugs, in comparison with older drugs, are more often prescribed to patients who have not responded satisfactorily to established related drugs or as first-line therapy to patients with a high baseline risk for adverse outcomes (i.e. channelling). However, these patients are less likely to ben...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/00002018-200831020-00004
更新日期:2008-01-01 00:00:00
abstract:: ...
journal_title:Drug safety
pub_type: 评论,信件
doi:10.1007/s40264-018-0670-2
更新日期:2018-06-01 00:00:00
abstract:INTRODUCTION:Adverse event (AE) under-reporting has been a recurrent issue raised during health authorities Good Clinical Practices (GCP) inspections and audits. Moreover, safety under-reporting poses a risk to patient safety and data integrity. The current clinical Quality Assurance (QA) practices used to detect AE un...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-019-00831-4
更新日期:2019-09-01 00:00:00
abstract::The generation of autoantibodies and autoimmune diseases such as systemic lupus erythematosus has been associated with the use of certain drugs in humans. Early reports suggested that procainamide and hydralazine were associated with the highest risk of developing lupus, quinidine with a moderate risk and all other dr...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/11588500-000000000-00000
更新日期:2011-05-01 00:00:00
abstract::Menorrhagia affects the lives of many women. The assessment of menstrual flow is highly subjective and gauging the severity of the condition by objective assessment of menstrual blood loss is impractical. In treating menorrhagia, the primary aim should be to improve quality of life. Women are willing to undergo quite ...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200427020-00001
更新日期:2004-01-01 00:00:00
abstract::NSAIDs are widely used to treat pain and inflammation in osteoarthritis. Their use in this indication is generally intermittent and fluctuates with the intensity of the disease. Nonetheless, success of the therapy is frequently limited by injury to the gastrointestinal mucosa and complications such as bleeding, ulcera...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200427030-00003
更新日期:2004-01-01 00:00:00
abstract::After initial enthusiasm, the use of monoamine oxidase inhibitors (MAOIs) has been limited by the wide range of MAOI-drug and MAOI-food interactions that are possible, particularly with sympathomimetic medications or tyramine-containing foods, resulting in hypertensive reactions. Despite their clinical benefits, this ...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199614040-00002
更新日期:1996-04-01 00:00:00
abstract::The prognosis is generally poor for patients who experience a cardiac arrest. The most common causes of sudden cardiac arrest are massive pulmonary embolism (PE) and acute myocardial infarction (MI). While thrombolysis is a first-line treatment option in massive PE and acute MI, cardiopulmonary resuscitation (CPR) has...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200326060-00001
更新日期:2003-01-01 00:00:00
abstract::Pharmacovigilance science has traditionally been a discipline focussed on the postmarketing or post-authorisation period, with due attention directed towards pre-clinical safety data, clinical trials and adverse events. As the biological sciences have evolved, pharmacovigilance has slowly shifted toward earlier, proac...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200629080-00003
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:There are no head-to-head randomized controlled trials comparing different direct oral anticoagulants (DOACs). Thus, we systematically reviewed and meta-analyzed observational studies assessing the comparative effectiveness and safety of DOACs for stroke prevention in patients with atrial fibrillation (AF). ...
journal_title:Drug safety
pub_type: 杂志文章,meta分析
doi:10.1007/s40264-019-00842-1
更新日期:2019-10-01 00:00:00
abstract::The development of antiretroviral therapy (ART) has dramatically increased the lifespan of HIV patients but treatment is complicated by numerous adverse effects and toxicities. ART complications include neuropsychiatric, metabolic, gastrointestinal, cardiac, and numerous other toxicities, and clinicians often have to ...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.1007/s40264-016-0440-y
更新日期:2016-10-01 00:00:00
abstract::Osteoporosis is a major public health problem occurring primarily among the postmenopausal population. Osteoporosis is a preventable disease, but despite several advances in its prevention, treatment of the established disease to date remains a major challenge to be managed by primary care physicians. Stabilisation of...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199411030-00004
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Depressive disorders and use of antidepressants are associated with adverse effects on sexual function. In pharmacoepidemiological studies, sexual disorders are reported by more than 50 % of patients taking serotonin reuptake inhibitors (SRIs). OBJECTIVE:The aim of this study was to determine the reporting ...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-013-0069-z
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:For many regularly used drugs, evidence for safe use in pregnancy has not been established. Despite this, international studies have identified high levels of drug prescribing among pregnant women. OBJECTIVE:To investigate the patterns of prescribing of drugs to women who gave birth in Tayside, Scotland, in...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/11532330-000000000-00000
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Patients receiving warfarin therapy are discouraged from taking herbal medicines. Whether patients adhere to this advice and, if they do not, the types of products they use, are not known. OBJECTIVE:The objective of this observational study was to estimate the magnitude of use of herbal medicines among Chin...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/00002018-200326080-00004
更新日期:2003-01-01 00:00:00
abstract::Similar to other beta-lactam antibacterials, carbapenems have a neurotoxic potential that seems to be higher than that of the penicillins and cephalosporins. Seizures have been reported in several large studies of patients treated with imipenem/cilastatin. However, it seems clear that the main factor increasing the ri...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199615020-00001
更新日期:1996-08-01 00:00:00
abstract::Pharmacovigilance is the science of monitoring the effects of medicinal products to identify and evaluate potential adverse reactions and provide necessary and timely risk mitigation measures. Intelligent automation technologies have a strong potential to automate routine work and to balance resource use across safety...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-020-01030-2
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Eosinophilic pneumonia (EP) has been noted in association with daptomycin use. The product labelling was recently updated to include EP in the Warnings and Precautions and Post-Marketing Experience sections. OBJECTIVE:The objective of this study was to analyse adverse event (AE) reports submitted to the US ...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/11597460-000000000-00000
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Case reports have related the use of HMG-CoA reductase inhibitors ('statins') to Parkinson's disease (PD). Paradoxically, however, statins may have potentially beneficial effects on neurodegenerative diseases due to their anti-inflammatory properties. OBJECTIVE:To explore the risk of the development of PD i...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/00002018-200831050-00004
更新日期:2008-01-01 00:00:00