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Recapitulation of genome-wide association studies on pulse pressure and mean arterial pressure in the Korean population.

Abstract：

:Increased pulse pressure (PP) and decreased mean arterial pressure (MAP) are strong prognostic predictors of adverse cardiovascular events. Recently, the International Consortium for Blood Pressure Genome-Wide Association Studies (ICBP-GWAS) reported eight loci that influenced PP and MAP. The ICBP-GWAS examined 51 cohorts--comprising 122 671 individuals of European ancestry--and identified eight SNPs: five that governed PP and three that controlled MAP. Six of these loci were novel. To replicate these newly identified loci and examine genetic architecture of PP and MAP between European and Asian populations, we conducted a meta-analysis of the eight SNPs combining data from ICBP and general population-based Korean cohorts. Two SNPs (rs13002573 (FIGN) and rs871606 (CHIC2)) for PP and two SNPs (rs1446468 (FIGN) and rs319690 (MAP4)) for MAP were replicated in Koreans. Although our GWAS only found moderate association, we believe that the findings promote us to propose that a similar genetic architecture governs PP and MAP in Asians and Europeans. However, further studies will be needed to confirm the possibility using other Asian population.

journal_name

J Hum Genet

journal_title

Journal of human genetics

authors

Hong KW,Min H,Heo BM,Joo SE,Kim SS,Kim Y

doi

10.1038/jhg.2012.31

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

391-3

issue

6

eissn

1434-5161

issn

1435-232X

pii

jhg201231

journal_volume

57

pub_type

杂志文章

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