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Anxiety traits associated with a polymorphism in the serotonin transporter gene regulatory region in the Japanese.

Abstract：

:We determined polymorphism in the serotonin (5-HT) transporter gene-linked polymorphic region (5-HTTLPR) in 501 healthy Japanese, individuals, using the polymerase chain reaction of Lesch et al., with minor modifications. The distribution of allele frequencies was determined and found to differ from that in Caucasians. We also investigated the relationship of polymorphism in 5-HTTLPR to anxiety traits, by having 189 of the 501 subjects complete a self-rating questionnaire for anxiety and depression. Subjects with the short/short (s/s) genotype had significantly higher anxiety scores than those with the long/long (l/l) or l/s genotype. It is suggested that populations with the s/s genotype of 5-HTTLPR have stronger anxiety-related personality traits than those with the 1 allele.

journal_name

J Hum Genet

journal_title

Journal of human genetics

authors

Murakami F,Shimomura T,Kotani K,Ikawa S,Nanba E,Adachi K

doi

10.1007/s100380050098

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

15-7

issue

1

eissn

1434-5161

issn

1435-232X

journal_volume

44

pub_type

杂志文章

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