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The medaka fish Tol2 transposable element can undergo excision in human and mouse cells.

Abstract：

:Tol2 is an active DNA-based transposable element identified in the medaka fish, Oryzias latipes. Originating from a vertebrate and belonging to the hAT ( hobo/ Activator/ Tam3) transposable element family, featuring a wide distribution among organisms, Tol2 would be expected to be active if introduced into mammals. We, therefore, examined if excision, one part of the transposition reaction, can occur in human and mouse culture cells. A Tol2 clone was introduced into cells and, after incubation, recovered. PCR and sequencing analysis provided evidence for precise and near precise excision in these cells. Tol2 can thus be expected to serve as a material for developing a gene transfer vector and other genetic tools applicable to mammals. It was also suggested that an intact Tol2 element could retain autonomy as a transposable element in mammalian cells.

journal_name

J Hum Genet

journal_title

Journal of human genetics

authors

Koga A,Iida A,Kamiya M,Hayashi R,Hori H,Ishikawa Y,Tachibana A

doi

10.1007/s10038-003-0016-4

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

231-235

issue

5

eissn

1434-5161

issn

1435-232X

pii

10.1007/s10038-003-0016-4

journal_volume

48

pub_type

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