Cloning and characterization of the murine P2XM receptor gene.

Abstract:

:We have isolated the murine counterpart of the human P2XM gene (mP2XM), a P2X purinoceptor that is expressed predominantly in skeletal muscle. The mP2XM gene, consisting of 12 exons that span 10 kb of genomic DNA, encodes a 379-amino-acid product with 83% identity to the human homologue. Two potential transmembrane domains (M1 and M2) are present in the predicted product, and a segment resembling the H5 region of voltage-gated ion channels is completely conserved between human and mouse P2XM proteins. Predominant expression of mP2XM in murine skeletal muscle was confirmed by Northern-blot analysis, and a low level of expression was detectable in lung tissue, although human lung does not express P2XM.

journal_name

J Hum Genet

authors

Nawa G,Urano T,Tokino T,Ochi T,Miyoshi Y

doi

10.1007/s100380050086

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

262-7

issue

4

eissn

1434-5161

issn

1435-232X

journal_volume

43

pub_type

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