Abstract:
:We have isolated the murine counterpart of the human P2XM gene (mP2XM), a P2X purinoceptor that is expressed predominantly in skeletal muscle. The mP2XM gene, consisting of 12 exons that span 10 kb of genomic DNA, encodes a 379-amino-acid product with 83% identity to the human homologue. Two potential transmembrane domains (M1 and M2) are present in the predicted product, and a segment resembling the H5 region of voltage-gated ion channels is completely conserved between human and mouse P2XM proteins. Predominant expression of mP2XM in murine skeletal muscle was confirmed by Northern-blot analysis, and a low level of expression was detectable in lung tissue, although human lung does not express P2XM.
journal_name
J Hum Genetjournal_title
Journal of human geneticsauthors
Nawa G,Urano T,Tokino T,Ochi T,Miyoshi Ydoi
10.1007/s100380050086subject
Has Abstractpub_date
1998-01-01 00:00:00pages
262-7issue
4eissn
1434-5161issn
1435-232Xjournal_volume
43pub_type
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