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No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population.

Abstract：

:Panic disorder (PD) is a severe and chronic psychiatric disorder, with significant genetic components in the etiology. Brain-derived neurotrophic factor (BDNF) gene, which has regulatory effects on neurotransmitter systems such as serotonin and dopamine, is a candidate for susceptibility locus of PD. This study investigated three single-nucleotide polymorphisms (SNPs) of BDNF (rs6265 (Val66Met), rs11030104 and rs7103411) in Japanese patients with PD and controls. No significant association was observed between the three SNPs and PD. No association of the Val66Met was consistent with two small studies in Japanese and Chinese populations. We therefore conclude that the BDNF polymorphism may not play a major role in PD in the East Asian populations.

journal_name

J Hum Genet

journal_title

Journal of human genetics

authors

Otowa T,Shimada T,Kawamura Y,Liu X,Inoue K,Sugaya N,Minato T,Nakagami R,Tochigi M,Umekage T,Kasai K,Kato N,Tanii H,Okazaki Y,Kaiya H,Sasaki T

doi

10.1038/jhg.2009.46

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

437-9

issue

8

eissn

1434-5161

issn

1435-232X

pii

jhg200946

journal_volume

54

pub_type

杂志文章

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