Abstract：
BACKGROUND:This study investigated prospectively the role of human papillomavirus (HPV) in paranasal inverted papilloma (IP). METHODS:HPV presence and viral load and physical status of HPV-16 were examined by polymerase chain reaction-based methods using fresh frozen samples obtained from 13 patients with IP (IP group), 11 with squamous cell carcinoma in the maxillary sinus (SCC group) and 39 with chronic inflammatory lesions (inflammatory group). RESULTS:The presence of the HPV genome was detected in 46.1%, 27.3% and 7.6% of patients in the IP, SCC and inflammatory groups, respectively. The IP group showed significantly higher HPV-positive rates than the inflammatory group. All types of HPV detected were high-risk HPV, especially HPV-16. The relative HPV-16 copy numbers varied from 2.5 to 1524.1 per 50 ng genomic DNA. The viral load was higher in the IP and SCC groups than in the inflammatory group. In the IP group, no significant relationship was found between HPV-16 viral load and clinical characteristics, or between physical status and clinical characteristics. One patient with IP and concomitant squamous cell carcinoma, however, showed high viral load and integration. CONCLUSIONS:HPV infection is involved in the pathogenesis of IP, and high viral load and integration of HPV have an important role in malignant lesion in association with IP.
journal_name
Rhinologyjournal_title
Rhinologyauthors
Hasegawa M,Deng Z,Maeda H,Yamashita Y,Matayoshi S,Kiyuna A,Agena S,Uehara T,Suzuki Mdoi
10.4193/Rhino11.106subject
Has Abstractpub_date
2012-03-01 00:00:00pages
87-94issue
1eissn
0300-0729issn
1996-8604pii
1063journal_volume
50pub_type
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