Abstract：
BACKGROUND:Nasal polyposis (NP) is an inflammatory disease of the upper nasal airways frequently present in CF patients. Interferon-Related Developmental Regulator 1 (IFRD1) gene was reported as a possible modifier of CF lung disease severity. Three IFRD1 SNPs were analyzed to investigate a possible effect on the development of NP in CF patients. METHODS AND PATIENTS:The DNA of 143 patients with CF (40 with and 103 without NP) was purified from peripheral blood samples. IFRD1 SNPs (rs7817, rs3807213, rs6968084) were genotyped by restriction enzyme analysis. RESULTS:The T allele of the common polymorphisms rs7817 and the rs7817-rs3807213 haplotype were associated with NP (p = 0.002 and 0.004, respectively). CONCLUSIONS:These results showed the association of the IFRD1-rs7817 polymorphism with NP in CF patients.
journal_name
Rhinologyjournal_title
Rhinologyauthors
Baldan A,Lo Presti AR,Belpinati F,Castellani C,Bettin MD,Xumerle L,Pignatti PR,Malerba G,Bombieri Cdoi
10.4193/Rhin14.229subject
Has Abstractpub_date
2015-12-01 00:00:00pages
359-64issue
4eissn
0300-0729issn
1996-8604pii
1351journal_volume
53pub_type
杂志文章相关文献
RHINOLOGY文献大全abstract：BACKGROUND:Epidemiological studies on chronic rhinosinusitis with nasal polyps are scarce and mostly based on questionnaires. Data obtained with such approaches can be unreliable, thus endoscopy is a prerequisite for an accurate estimate of the prevalence of nasal polyps. The objective of this study was to establish th...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhin14.016
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Despite the common occurrence of rhinological pathology presenting to the ENT clinic, routine testing of olfactory ability is rarely performed. OBJECTIVES:The aim of this study was to determine the role of routine olfactory testing. METHODS:This was a prospective study conducted in the outpatient clinic of...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
abstract：:A group of 51 patients was studied by a technique of active posterior rhinomanometry that assessed the influence of breath holding, hyperventilation, and exercise on nasal resistance. Breath hodling of 30 seconds or longer produced a decrease in nasal resistance in most of the subjects tested. Hyperventilation had var...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1978-12-01 00:00:00
abstract：:Recently endonasal surgery has been considered to be a valuable contribution in the management of paranasal sinus osteoma. A retrospective evaluation study of 34 frontoethmoidal osteomas (23 frontal and 11 ethmoidal osteomas) treated at a tertiary care facility from 1990 to 1999 is presented. Twenty three osteomas (68...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2001-06-01 00:00:00
abstract：:Our study was made to prove the second-generation surgical fibrin sealant Quixil to be an effective substitute for nasal packing, chemical coagulation and cautery in management of patients with epistaxis. Our series includes 204 patients with anterior epistaxis (186), and with posterior epistaxis (18) as results of tr...
journal_title：Rhinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2002-06-01 00:00:00
abstract：:Allergic rhinitis, a risk factor for bronchial asthma, is a global health problem that impairs patients` physical and social activity and consequently their quality of life. Specific Immunotherapy (SIT) involves the administration, subcutaneously or sublingually, of increasing doses of the causative allergen, in order...
journal_title：Rhinology
pub_type： 杂志文章,评审
doi：10.4193/Rhino12.086
更新日期：2013-06-01 00:00:00
abstract：:The nose is a three-walled pyramid separated into two nostrils by a midline septum. The septum has been shown to provide considerable support to the shape of the nose. Previously nasal trauma was thought to damage solely the anterior cartilaginous septum with sparing of the posterior bony septum. Cadaver nasal fractur...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1987-06-01 00:00:00
abstract：BACKGROUND:Not much is known about long-term satisfaction of septoplasty. The goal of this study was to assess disease specific quality of life outcomes as well as satisfaction at more than 10 years follow-up after septoplasty. METHODOLOGY/PRINCIPAL:The study was conducted as a retrospective questionnaire study (based...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhino11.218
更新日期：2012-06-01 00:00:00
abstract：AIM:The prevalence of intracellular Staphylococcus aureus organisms in the nasal mucosa of patients with recurrent infectious rhinosinusitis episodes was studied. METHOD:Twenty-seven consecutive adult patients who failed medical management of chronic rhinosinusitis (CRS) of multiple origins, associated or not with nas...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:Long-term rhinoflowmetry assesses bilateral nasal flow over 24 hours. In the present study, we evaluated the effects of a standard dose of oxymetazoline topical nasal spray, a widely used over-the-counter drug, on the nasal cycle, since the exact long-term effects, such as the duration of the decongestive ef...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhino12.032
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Several texts detail the possible complications of nasal reconstruction but few critically describe a series. We present an audit of the complications of 95 major nasal reconstructions. METHODS:This is a retrospective analysis of 95 consecutive major nasal reconstructions (49 male, 46 female, aged between 4...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhin09.050
更新日期：2010-03-01 00:00:00
abstract：:The site of origin of sino-nasal polyps was documented in 113 consecutive patients undergoing functional endoscopic sinus surgery (FESS). These patients were assigned pre-operatively to 4 clinical groups according to the out-patient recorded endoscopic appearance of their nasal cavities; chronic rhinosinusitis without...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2005-09-01 00:00:00
abstract：:Pleomorphic adenoma is the most frequent tumor of the major salivary glands. It is rarely located in the lacrymal glands and is unusual in the nasal cavity. A rare case of a pleomorphic adenoma of the nose is presented along with a review of the literature. The use of nasal endoscopy in removing tumors of the nose and...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:The role of tranexamic acid in patients undergoing endoscopic sinus surgery (ESS) is not clearly defined. The aim of our study is to systematically review the existing evidence on the role of tranexamic acid in patients undergoing ESS. METHODOLOGY:Systematic search of MEDLINE (1950 - 2013), EMBASE (1980 - 2...
journal_title：Rhinology
pub_type： 杂志文章,meta分析,评审
doi：10.4193/Rhin13.042
更新日期：2013-12-01 00:00:00
abstract：:The review discusses the physiological and pathophysiological mechanisms associated with the symptoms of acute and chronic rhinosinusitis. An understanding of symptom mechanisms is important for the clinical diagnosis of rhinosinusitis and is important in assessing the efficacy of surgical and medical treatments for r...
journal_title：Rhinology
pub_type： 杂志文章,评审
doi：
更新日期：2011-06-01 00:00:00
abstract：:One disadvantage of functional endoscopic sinus surgery is the frequent post-operative cavity toilet considered necessary by most surgeons, which is not only costly but also very unwelcome to patients. In the Royal Berkshire Hospital in Reading, we have reviewed a series of 120 patients who underwent FESS over an 18-m...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：:In the literature, remarks on the depiction of the anterior nasal septum in prehistoric times cannot be found. Studying works of art from some archaeological sites of Asia, Asia Minor, Near East, Egypt, and Southeastern Europe the anatomical depiction of the columella and the nostrils in human figures are shown. These...
journal_title：Rhinology
pub_type： 历史文章,杂志文章
doi：
更新日期：2006-06-01 00:00:00
abstract：:Nasal cytology has become a valuable tool in the assessment of a multitude of nasal pathologies in children. Collection methods differ significantly and even though the use of the nasal curette is regarded as the most reliable in adults, most practitioners use the nasal swab in children. However, no studies have valid...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhin16.287
更新日期：2017-09-01 00:00:00
abstract：:Fungal sinusitis should always be considered in the differential diagnosis of chronic or recurring sinusitis resistant to adequate medical treatment. A high index of suspicion is necessary for the diagnosis, and the clinical examination is rarely conclusive. The definitive diagnosis depends on the pathologist in most ...
journal_title：Rhinology
pub_type： 杂志文章,评审
doi：
更新日期：1995-06-01 00:00:00
abstract：:Intranasal corticosteroids are increasingly used to treat allergic rhinitis and their long-term use is generally safe. However, the long-term safety of each molecule should be assessed. The main aim of this multicenter, prospective, randomized, open-label study was to evaluate the effect of triamcinolone acetonide aqu...
journal_title：Rhinology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2001-03-01 00:00:00
abstract：:Electron-microscope investigation on the epithelium was carried out in 23 nasopharyngeal tonsils. Adenoidectomy was performed on the ground of recurrent adenoiditis in the interattacks period in 13 boys and 10 girls between the ages of 2 to 4. The presence of five characteristic cellular types was found on the surface...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1984-09-01 00:00:00
abstract：PURPOSE:The aim of this study is to evaluate the outcome of patients with maxillary sinus carcinoma after radiotherapy regarding local control, prognostic factors and morbidity of treatment. MATERIALS AND METHODS:Between January 1983 and December 1996, 79 cases of maxillary sinus carcinoma without any evidence of dist...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：:We compared the efficacy and safety of 5 mg cetirizine (CTZ), 120 mg pseudoephedrine retard (PER) and their combination (COM), given twice daily for three weeks, for the treatment of perennial allergic rhinitis. Two hundred and ten evaluable patients (97 males and 113 females) were included in the study and randomly a...
journal_title：Rhinology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1996-06-01 00:00:00
abstract：:With chronic maxillary sinusitis the pathological changes in the diseased mucosa used to be considered irreversible, thus necessitating its radical removal, which is only possible with the Caldwell-Luc operation. The discovery of the reversibility of the pathology caused a shift from the Caldwell-Luc towards endonasal...
journal_title：Rhinology
pub_type： 杂志文章,评审
doi：
更新日期：1988-03-01 00:00:00
abstract：:Tritiated norepinephrine was incorporated into isolated dog nasal mucosa. Electrical stimulation of this mucosa induced a release of the tritiated norepinephrine. Acetylcholine inhibited this release in a dose-related manner. The inhibition is prevented by atropine. This data provides further evidence for the existenc...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1985-03-01 00:00:00
abstract：:We have compared the histological aspects of nasal mucosa biopsies (n = 130) obtained during bilateral polypectomy and ethmoidectomy performed in black African (n = 50), Chinese (n = 30) and Caucasian patients (n = 50) suffering from bilateral nasal polyposis (NP). The three groups of patients were matched for age and...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:Snoring is a significant problem both for the patient and for the bedpartner. It is well known that nasal stuffiness can contribute to snoring, and sleep quality may deteriorate because of the snoring. Nasal dilation can reduce snoring and improve sleep. Thirty-five habitual snorers (18 female, 17 male) and their bedp...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：BACKGROUND:Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease, and its pathogenesis remains controversial. This study aimed to examine the involvement of fungi in CRSwNP pathogenesis. METHODS:We enrolled 29 controls and 111 CRSwNP patients. We analyzed fungi in the nasal secretions, serum fun...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhin18.225
更新日期：2020-04-01 00:00:00
abstract：:Twenty-seven patients with acute frontal sinusitis, collected during a 4-month period, were examined with plain radiographics and MRI both at the time of diagnosis and one month later. Findings in the frontal and ethmoidal sinuses were recorded. Frontal sinus trephination was performed in 13 of the 27 cases. The study...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:During 4 weeks of the grass pollen season in the south of Sweden 27 patients with seasonal allergic rhinitis were treated topically with a beta-adrenoceptor stimulant, KWD 2131, which in an earlier rhinomanometric study had shown a prophylactic effect at nasal allergen provocations in hay-fever patients. A clinical ef...
journal_title：Rhinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1982-09-01 00:00:00
