Local fungus-specific Immunoglobulin E production in chronic rhinosinusitis with nasal polyps.

Abstract:

BACKGROUND:Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease, and its pathogenesis remains controversial. This study aimed to examine the involvement of fungi in CRSwNP pathogenesis. METHODS:We enrolled 29 controls and 111 CRSwNP patients. We analyzed fungi in the nasal secretions, serum fungus-specific immunoglobulin E (IgE) levels, and nasal polyp (NP) IgE levels. Moreover, we evaluated the correlation between patients' IgE levels and computed tomography (CT) scores. RESULTS:There was no difference in fungal detection rate between CRSwNP patients with and without asthma. Specific IgEs against various antigens were highly detectable in NPs of CRSwNP patients. In CRSwNP patients, fungus-specific IgE levels in NPs were correlated with CT scores. Serum fungus-specific IgEs became undetectable after operation in more than half of the CRSwNP patients without asthma but not in those with asthma. Other serum airborne antigen-specific IgEs did not become undetectable after operation. CONCLUSIONS:Fungus-specific IgEs were highly detectable in NPs of CRSwNP patients, and NPs comprised a major region of specific IgE production. Fungi may therefore play an important role in CRSwNP pathogenesis by inducing Th2 immune responses, including IgE synthesis.

journal_name

Rhinology

journal_title

Rhinology

authors

Ohki Y,Okamoto Y,Iinuma T,Yamamoto H,Toyotome T,Yahiro M,Yonekura S,Sakurai D,Kamei K

doi

10.4193/Rhin18.225

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

136-144

issue

2

eissn

0300-0729

issn

1996-8604

pii

2229

journal_volume

58

pub_type

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